{"id":957,"date":"2025-01-24T11:38:42","date_gmt":"2025-01-24T11:38:42","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker&#038;p=957"},"modified":"2025-06-10T09:19:01","modified_gmt":"2025-06-10T09:19:01","slug":"c4m","status":"publish","type":"biomarker","link":"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/c4m\/","title":{"rendered":"C4M"},"content":{"rendered":"\n<p>A neo-epitope fragment of type IV collagen generated by matrix metalloproteinase activity, enabling non-invasive assessment of basement membrane degradation and extracellular matrix remodeling in chronic inflammatory and fibrotic diseases.<\/p>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Key features and values<\/summary>\n<ul class=\"wp-block-list\">\n<li>Quantifies specific fragments of type IV collagen produced by matrix metalloproteinase activity.<\/li>\n\n\n\n<li>Reflects basement membrane degradation associated with tissue remodeling.<\/li>\n\n\n\n<li>Provides a non-invasive measure of extracellular matrix turnover in various pathological conditions.<\/li>\n\n\n\n<li>Supports monitoring of disease progression and response to therapies targeting extracellular matrix remodeling.<\/li>\n\n\n\n<li>Applicable in research on diseases characterized by basement membrane disruption, such as rheumatoid arthritis and cancer.<\/li>\n\n\n\n<li>Facilitates evaluation of interventions aimed at modulating extracellular matrix degradation.<\/li>\n\n\n\n<li>Complements other biomarkers for a comprehensive assessment of tissue remodeling dynamics.<\/li>\n<\/ul>\n<\/details>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Description<\/summary>\n<p style=\"font-size:16px\">The C4M biomarker assay measures specific neo-epitope fragments of type IV collagen generated through matrix metalloproteinase activity, serving as an indicator of basement membrane degradation and extracellular matrix remodeling. This non-invasive assay provides insights into pathological tissue remodeling processes, particularly in conditions such as rheumatoid arthritis, cancer, and fibrotic diseases. By quantifying collagen degradation products associated with matrix metalloproteinase activity, the C4M assay aids in monitoring disease progression, evaluating treatment efficacy, and understanding the underlying mechanisms of tissue remodeling. It serves as a valuable tool in both clinical and research settings for assessing the dynamics of basement membrane and extracellular matrix turnover.<\/p>\n\n\n\n<p style=\"font-size:16px\"><em>Nordic Bioscience\u2019s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.<\/em><\/p>\n<\/details>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/?search=c4m\">Order C4M and other biomarkers<\/a><\/div>\n<\/div>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col xl:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Would you like to learn more? 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They are using a pipette to transfer liquid into small bottles, surrounded by lab equipment and vials.\">\n        <\/figure>   \n   <\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>A neo-epitope fragment of type IV collagen generated by matrix metalloproteinase activity, enabling non-invasive assessment of basement membrane degradation and extracellular matrix remodeling in chronic inflammatory and fibrotic diseases.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"biomarker-panel":[80,73,5266,5277,76,5268,78,5270,5282,5279,5280,67,5273,5265,65],"commercial-assays":[],"therapeutic-area":[45,47,51,50,46,82,49,44],"class_list":["post-957","biomarker","type-biomarker","status-publish","hentry","biomarker-panel-atherosclerotic-plaque-instability","biomarker-panel-atopic-dermatitis","biomarker-panel-celiac-disease","biomarker-panel-cutaneous-lupus-erythematosus","biomarker-panel-lung-epithelial-damage-thrombosis","biomarker-panel-mucosal-damage","biomarker-panel-multiple-sclerosis","biomarker-panel-nordicibdtrace","biomarker-panel-proteolytic-activities","biomarker-panel-psoriasis","biomarker-panel-psoriatic-arthritis","biomarker-panel-rheumatrace","biomarker-panel-scleroderma","biomarker-panel-systemic-lupus-erythematosus","biomarker-panel-systemic-sclerosis","therapeutic-area-cancer","therapeutic-area-cardiovascular-diseases","therapeutic-area-dermatology","therapeutic-area-gastroenterology","therapeutic-area-hepatic-diseases","therapeutic-area-neuroscience","therapeutic-area-respiratory-diseases","therapeutic-area-rheumatology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker\/957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/biomarker"}],"version-history":[{"count":17,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker\/957\/revisions"}],"predecessor-version":[{"id":7344,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker\/957\/revisions\/7344"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=957"}],"wp:term":[{"taxonomy":"biomarker-panel","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker-panel?post=957"},{"taxonomy":"commercial-assays","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/commercial-assays?post=957"},{"taxonomy":"therapeutic-area","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/therapeutic-area?post=957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}