{"id":940,"date":"2025-01-24T10:49:37","date_gmt":"2025-01-24T10:49:37","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker&#038;p=940"},"modified":"2025-06-10T09:21:30","modified_gmt":"2025-06-10T09:21:30","slug":"c3m","status":"publish","type":"biomarker","link":"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/c3m\/","title":{"rendered":"C3M"},"content":{"rendered":"\n<p>A matrix metalloproteinase-generated fragment of type III collagen, reflecting extracellular matrix remodeling and enabling assessment of fibrotic activity.<\/p>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Key features and values<\/summary>\n<ul class=\"wp-block-list\">\n<li>Measures degradation fragments of type III collagen resulting from matrix metalloproteinase activity.<\/li>\n\n\n\n<li>Reflects dynamic extracellular matrix remodeling and connective tissue turnover.<\/li>\n\n\n\n<li>Provides a non-invasive indicator of fibrotic processes in chronic and progressive diseases.<\/li>\n\n\n\n<li>Supports monitoring of disease progression and resolution in fibrotic, inflammatory, and degenerative conditions.<\/li>\n\n\n\n<li>Facilitates assessment of therapeutic interventions targeting extracellular matrix turnover.<\/li>\n\n\n\n<li>Enables research into the molecular mechanisms of fibrosis and tissue remodeling.<\/li>\n\n\n\n<li>Aids in patient stratification and prognosis for studies involving tissue remodeling disorders.<\/li>\n<\/ul>\n<\/details>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Description<\/summary>\n<p style=\"font-size:16px\">The C3M biomarker assay quantifies neo-epitope fragments of type III collagen generated through matrix metalloproteinase-driven cleavage, serving as a specific indicator of extracellular matrix remodeling and fibrotic activity. This non-invasive assay provides a dynamic measure of connective tissue turnover, applicable to research and monitoring of fibrotic, inflammatory, and degenerative diseases. By capturing changes in type III collagen breakdown, C3M supports studies on disease progression, response to therapy, and the underlying mechanisms of tissue remodeling.<\/p>\n\n\n\n<p style=\"font-size:16px\"><em>Nordic Bioscience\u2019s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.<\/em><\/p>\n<\/details>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/?search=c3m\">Order C3M and other biomarkers<\/a><\/div>\n<\/div>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col xl:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Would you like to learn more? 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They are using a pipette to transfer liquid into small bottles, surrounded by lab equipment and vials.\">\n        <\/figure>   \n   <\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>A matrix metalloproteinase-generated fragment of type III collagen, reflecting extracellular matrix remodeling and enabling assessment of fibrotic activity.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"biomarker-panel":[73,5266,5180,5211,5277,5179,63,74,5175,5182,69,5262,54,5181,5268,5270,5251,5263,5282,5279,5280,67,5273,5274,5265,65],"commercial-assays":[],"therapeutic-area":[45,47,51,50,46,48,5198,49,44],"class_list":["post-940","biomarker","type-biomarker","status-publish","hentry","biomarker-panel-atopic-dermatitis","biomarker-panel-celiac-disease","biomarker-panel-chronic-kidney-disease-ckd","biomarker-panel-copd","biomarker-panel-cutaneous-lupus-erythematosus","biomarker-panel-diabetic-kidney-disease-dkd","biomarker-panel-heart-outcome","biomarker-panel-hidradenitis-suppurutiva","biomarker-panel-igan-iga-nephropathy","biomarker-panel-idiopathic-pulmonary-fibrosis-ipf","biomarker-panel-joint-tissue-remodeling","biomarker-panel-kidney-translational","biomarker-panel-lung-fibrosis","biomarker-panel-lupus-nephritis-ln","biomarker-panel-mucosal-damage","biomarker-panel-nordicibdtrace","biomarker-panel-obesity","biomarker-panel-ostatrace","biomarker-panel-proteolytic-activities","biomarker-panel-psoriasis","biomarker-panel-psoriatic-arthritis","biomarker-panel-rheumatrace","biomarker-panel-scleroderma","biomarker-panel-skin-cancer-melanoma","biomarker-panel-systemic-lupus-erythematosus","biomarker-panel-systemic-sclerosis","therapeutic-area-cancer","therapeutic-area-cardiovascular-diseases","therapeutic-area-dermatology","therapeutic-area-gastroenterology","therapeutic-area-hepatic-diseases","therapeutic-area-renal-diseases","therapeutic-area-obesity","therapeutic-area-respiratory-diseases","therapeutic-area-rheumatology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker\/940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/biomarker"}],"version-history":[{"count":14,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker\/940\/revisions"}],"predecessor-version":[{"id":6836,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker\/940\/revisions\/6836"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=940"}],"wp:term":[{"taxonomy":"biomarker-panel","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker-panel?post=940"},{"taxonomy":"commercial-assays","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/commercial-assays?post=940"},{"taxonomy":"therapeutic-area","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/therapeutic-area?post=940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}