{"id":775,"date":"2025-01-22T15:58:30","date_gmt":"2025-01-22T15:58:30","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker-solutions&#038;p=775"},"modified":"2025-06-06T09:00:20","modified_gmt":"2025-06-06T09:00:20","slug":"translational-models-in-hepatic-fibrosis","status":"publish","type":"biomarker-solution","link":"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/translational-models-in-hepatic-fibrosis\/","title":{"rendered":"Translational Models in Hepatic Fibrosis"},"content":{"rendered":"<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Strategic drug development in hepatic fibrosis<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>Navigating the drug development process successfully is essential and not without challenges and uncertainties. Employing strategies that enhance the probability of success is crucial. The FDA and EMA acknowledge that biomarker-based drug development strategies, paired with translational research, could provide a viable solution. This approach offers a biology-centric approach that reduces both time and costs while improving the overall likelihood of success.<\/p>\n<p>Nordic Bioscience effectively integrates innovative translational models with\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/technology\/nordic-proteinfingerprint-technology\/\" data-type=\"page\" data-id=\"2167\">Nordic ProteinFingerPrint Technology\u2122<\/a>\u00a0to translate findings efficiently. By using the same biomarkers throughout various clinical development stages, they create a seamless link between preclinical models and clinical applications. This strategically chosen development pathway significantly boosts the efficiency of drug development pipelines.<\/p>\n<p>Incorporating biomarker-based drug development strategies into translational research not only speeds up therapeutic advancements but also increases the chances of success. Nordic Bioscience\u2019s advanced translational models, combined with\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/technology\/nordic-proteinfingerprint-technology\/\" data-type=\"page\" data-id=\"2167\">ProteinFingerPrint\u2122 biomarkers<\/a>, play a crucial role in optimizing clinical development decision-making processes, ultimately ensuring better treatments for patients.<\/p>\n                <\/div>\n                                    <div class=\"mt-8 mb-4 xl:mb-8 links\">\n                        <h3 class=\"mb-2 text-blue group-[.dark]:text-fontlight text-body-sm\">Publications<\/h3>\n                        <ul class=\"flex flex-wrap gap-2\">\n                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=%22hepatic%20fibrosis%22\" target=\"_blank\">Hepatic fibrosis<\/a>\n                                    <\/li>\n                                                                                    <\/ul>\n                    <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/liver-large-poly-scaled.png\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Translational biomarkers in hepatic research<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <div class=\"blog-item\">\n<div class=\"container-fluid container-master\">\n<div class=\"block block-mb-negative block-imgs-fg block-grid block-theme-blue block-v-sm text-left fancyfake-item\">\n<div class=\"row mx-0\">\n<div class=\"col-12 col-lg-6 px-0\">\n<div class=\"block-content\">\n<div class=\"blog-item beelab hover\">\n<div class=\"container-fluid container-master\">\n<div class=\"block block-mb-negative block-imgs-fg block-grid block-theme-white block-v-sm text-left fancyfake-item\">\n<div class=\"row mx-0\">\n<div class=\"col-12 col-lg-6 px-0\">\n<div class=\"block-content\">\n<p>A major cornerstone of our approach is the combination of translational models with clinically validated biomarkers to improve drug development. To this end, we have evaluated our biomarkers&#8217; capability to bridge the gap between hepatic fibrosis patients and various model systems. These findings emphasize the pharmacodynamic and translational application of Nordic ProteinFingerPrint Technology\u2122.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/biomarker-panel\/copd\/therapeutic-area\/hepatic-diseases\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"_blank\">\n            Browse our hepatic biomarker portfolio            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/shutterstock-2162135319-scaled.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"one-column-block bg-grey py-10\">\n<div class=\"inner xl:p-10 xl:pt-20 xl:pb-20 lg:p-8 p-5 max-w-[1440px] mx-auto\">\n\n        <div class=\"max-w-[900px] mx-auto wysiwyg\">\n            <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">In Vitro Model\u2014Scar-in-a-Jar (SiaJ)<\/h2>\n            <p class=\"has-text-align-left\">The prolonged Scar-in-a-Jar is an innovative model that utilizes macromolecular crowding to enhance the formation, maturation, and deposition of the extracellular matrix in vitro.\u00a0The extracellular matrix\u00a0is essential for providing structural support to cells and regulating tissue repair and regeneration by serving as a reservoir for growth factors and cytokines.<\/p>\n<p class=\"has-text-align-left\">Understanding the dynamics of the extracellular matrix is crucial for developing therapeutic strategies for fibrosis. By employing macromolecular crowding, the model gains a three-dimensional like structure and increased complexity, making it a suitable translational model. This modulation demonstrates the model\u2019s effectiveness for screening antifibrotic effects directly on hepatic stellate cells.<\/p>\n<p><!-- wp:image {\"id\":703,\"sizeSlug\":\"large\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-703\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-1024x576.webp\" alt=\"\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-768x432.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience.webp 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 1.\u00a0<\/strong>Liver Scar-in-a-Jar (SIAJ)<\/em><\/figcaption><\/figure>\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n<section class=\"call-to-action\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col\">\n        <article style=\"background-image: url(https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/04\/lila-2-webp-1024x682.webp)\" class=\"bg-cover shadow-main flex overflow-clip flex-col justify-between px-5 py-10 rounded-md bg-gray-600 xl:p-40 text-column xl:rounded-xl after:content-[''] after:block after:inset-0 relative after:absolute after:bg-gradient-to-b from-black\/0 to-black\">\n            <div class=\"max-w-[900px] mx-auto relative z-10\">\n                <div class=\"text-center text-balance\">\n                     \n                    <\/div>\n                    <div class=\"mb-8 text-center !text-fontlight\/90 body-text text-balance\">\n                                            <\/div>\n                    \n                    \n                    <div class=\"flex flex-col items-center w-full gap-4 md:gap-6 xl:mt-8 xl:flex-row xl:justify-center group light-button\">\n                                                                                    <div class=\"w-full text-center md:w-auto\">\n\n                                            <a href=\"mailto:bd@nordicbioscience.com?subject=General%20Inquiry\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Interested to learn more? Reach out!            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                    <\/div>\n                                                                                            <\/div>\n                                                    <\/div>\n                    <\/article>\n                <\/div>\n            <\/section>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2><\/h2>\n<h2>In Vivo Model\u2014GAN-DIO model<\/h2>\n<p class=\"has-text-align-left\">The prolonged Scar-in-a-Jar is an innovative model that utilizes macromolecular crowding to enhance the formation, maturation, and deposition of the extracellular matrix in vitro.\u00a0The extracellular matrix\u00a0is essential for providing structural support to cells and regulating tissue repair and regeneration by serving as a reservoir for growth factors and cytokines.<\/p>\n<p class=\"has-text-align-left\">Understanding the dynamics of the extracellular matrix is crucial for developing therapeutic strategies for fibrosis. By employing macromolecular crowding, the model gains a three-dimensional like structure and increased complexity, making it a suitable translational model. This modulation demonstrates the model\u2019s effectiveness for screening antifibrotic effects directly on hepatic stellate cells.<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <p><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-703\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-1024x576.webp\" alt=\"\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-768x432.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience.webp 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/p>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6924f7a4471ea&quot;}\" data-wp-interactive=\"core\/image\" class=\"aligncenter size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"561\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on-async--click=\"actions.showLightbox\" data-wp-on-async--load=\"callbacks.setButtonStyles\" data-wp-on-async-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-pro-c6-demonstrate-screening-of-antifibrotic-effects-in-liver-1024x561.webp\" alt=\"\" class=\"wp-image-777\" style=\"object-fit:cover\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-pro-c6-demonstrate-screening-of-antifibrotic-effects-in-liver-1024x561.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-pro-c6-demonstrate-screening-of-antifibrotic-effects-in-liver-300x164.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-pro-c6-demonstrate-screening-of-antifibrotic-effects-in-liver-768x421.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-pro-c6-demonstrate-screening-of-antifibrotic-effects-in-liver-1536x841.webp 1536w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-pro-c6-demonstrate-screening-of-antifibrotic-effects-in-liver-2048x1122.webp 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on-async--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\"><em><strong>Figure 2.<\/strong>&nbsp;Effect of Fibrotic Cocktail and ALK5 Inhibitor on <a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3<\/a> and <a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">PRO-C6<\/a> Levels in Hepatic Stellate Cells: A Model for Antifibrotic Screening<\/em><\/figcaption><\/figure><\/div>\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"one-column-block bg-grey py-10\">\n<div class=\"inner xl:p-10 xl:pt-20 xl:pb-20 lg:p-8 p-5 max-w-[1440px] mx-auto\">\n\n        <div class=\"max-w-[900px] mx-auto wysiwyg\">\n            <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">A MASH model: Collagen type III and Collagen type VI in Non-obese inflammation and fibrosis (NIF) mice<\/h2>\n            <p>The rodent pro-peptide of type III collagen (rP3NP) and the Endotrophin-associated marker\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">nordicPRO-C6\u2122<\/a>, correlated significantly with liver fibrosis progression. rP3NP, a known tissue repair and fibrosis biomarker, showed sustained elevation from 6 to 25 weeks (Left figure). Similarly,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">nordicPRO-C6\u2122<\/a>, associated with fibrosis, steatosis, and inflammation, was significantly elevated in NIF mice between 6 and 12 weeks, normalizing thereafter (Figure 2). As\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">nordicPRO-C6\u2122<\/a>\u00a0is elevated in advanced fibrosis in\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/masld-sld-and-mash\/\" data-type=\"biomarker-solution\" data-id=\"743\">MASH<\/a>\u00a0patients, these findings suggest the potential utility of rP3NP and\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">nordicPRO-C6\u2122<\/a>\u00a0as markers for assessing anti-fibrotic therapies in NIF mice.<\/p>\n<p><!-- wp:image {\"lightbox\":{\"enabled\":true},\"id\":778,\"scale\":\"cover\",\"sizeSlug\":\"large\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/rp3np-rpro-c6-mouse-mash-model-nordic-bioscience.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-778\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/rp3np-rpro-c6-mouse-mash-model-nordic-bioscience-1024x576.webp\" alt=\"\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/rp3np-rpro-c6-mouse-mash-model-nordic-bioscience-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/rp3np-rpro-c6-mouse-mash-model-nordic-bioscience-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/rp3np-rpro-c6-mouse-mash-model-nordic-bioscience-768x432.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/rp3np-rpro-c6-mouse-mash-model-nordic-bioscience.webp 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 2.<\/strong>\u00a0Non-fasting serum levels of rP3NP (left) and <\/em><a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">nordicPRO-C6\u2122<\/a><em> biomarkers (right) in male (o) and female (\u2022) NIF mice at different ages (n = 8\u201312 mice\/age group). One-way ANOVA was used to compare the mean of the 3-week age group with the mean of the other age groups. 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