{"id":768,"date":"2025-01-22T13:04:32","date_gmt":"2025-01-22T13:04:32","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker-solutions&#038;p=768"},"modified":"2025-06-06T08:58:03","modified_gmt":"2025-06-06T08:58:03","slug":"enhanced-liver-fibrosis-elf-test","status":"publish","type":"biomarker-solution","link":"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/enhanced-liver-fibrosis-elf-test\/","title":{"rendered":"Enhanced Liver Fibrosis (ELF) Test"},"content":{"rendered":"<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">ELF\u2122 is a non-invasive test to assess fibrosis in liver and metabolic diseases<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <div>\n<h3 class=\"mb-1 small-title group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\"><strong>The ELF score<\/strong><\/h3>\n<\/div>\n<div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n<div class=\"blog-item\">\n<div class=\"container-fluid container-master\">\n<div class=\"block block-mb-negative block-imgs-fg block-grid block-theme-blue block-v-sm text-left fancyfake-item\">\n<div class=\"row mx-0\">\n<div class=\"col-12 col-lg-6 px-0\">\n<div class=\"block-content\">\n<p data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559683&quot;:0,&quot;335559685&quot;:0,&quot;335559731&quot;:0,&quot;335559737&quot;:0,&quot;335562764&quot;:2,&quot;335562765&quot;:1,&quot;335562766&quot;:4,&quot;335562767&quot;:0,&quot;335562768&quot;:4,&quot;335562769&quot;:0}\">The ELF score has been well-validated against biopsy-proven fibrosis across a range of chronic liver diseases (CLD) in both adult and pediatric populations.\u00a0The three direct markers of the ELF test provide complementary information, and the combined score outperforms both the individual markers and simple scores such as APRI or FIB-4.\u200b<\/p>\n<p data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559683&quot;:0,&quot;335559685&quot;:0,&quot;335559731&quot;:0,&quot;335559737&quot;:0,&quot;335562764&quot;:2,&quot;335562765&quot;:1,&quot;335562766&quot;:4,&quot;335562767&quot;:0,&quot;335562768&quot;:4,&quot;335562769&quot;:0}\">The performance of the ELF test for liver fibrosis has been well-established in the scientific literature, and ease of testing and interpretation support routine clinical use as an alternative to invasive biopsy.\u200b<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n                <\/div>\n                                    <div class=\"mt-8 mb-4 xl:mb-8 links\">\n                        <h3 class=\"mb-2 text-blue group-[.dark]:text-fontlight text-body-sm\">Publications<\/h3>\n                        <ul class=\"flex flex-wrap gap-2\">\n                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=elf%20score\" target=\"_blank\">ELF<\/a>\n                                    <\/li>\n                                                                                    <\/ul>\n                    <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/shutterstock-2162135319-scaled.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2>The ELF\u2122 scoring system<\/h2>\n<p>The Enhanced Liver Fibrosis (ELF\u2122) test is a noninvasive blood (serum) lab test designed to assess levels of three major components directly involved in liver matrix metabolism: hyaluronic acid (HA), procollagen III aminoterminal peptide (PIIINP), and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1).<\/p>\n<p>The analytes are automatically measured, and the software calculates and reports a unitless numeric score. Increasing ELF scores are linked to both biopsy-proven fibrosis and prognosis for clinically significant outcomes (Figure 1).<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1022\" height=\"331\" class=\"wp-image-770 aligncenter\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/elf-scoring-system-liver-metabolic-test-nordic-bioscience2.webp\" alt=\"\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/elf-scoring-system-liver-metabolic-test-nordic-bioscience2.webp 1022w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/elf-scoring-system-liver-metabolic-test-nordic-bioscience2-300x97.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/elf-scoring-system-liver-metabolic-test-nordic-bioscience2-768x249.webp 768w\" sizes=\"auto, (max-width: 1022px) 100vw, 1022px\" \/><figcaption class=\"wp-element-caption\"><em><em><em><strong>Figure 1.\u00a0<\/strong>The ELF\u2122 scoring system<\/em><\/em><\/em><!-- wp:image {\"id\":773,\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><\/figure>\n<p><em><em><!-- \/wp:image --><!-- wp:image {\"id\":6530,\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/em><\/em><\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><\/figure>\n<p><em><!-- \/wp:image --><br \/>\n<\/em><\/p>\n<\/figcaption><\/figure>\n<p><!-- \/wp:image --><\/p>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <p><img loading=\"lazy\" decoding=\"async\" width=\"1919\" height=\"451\" class=\"wp-image-773 aligncenter\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/siemens-healthineers-logo.webp\" alt=\"\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/siemens-healthineers-logo.webp 1919w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/siemens-healthineers-logo-300x71.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/siemens-healthineers-logo-1024x241.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/siemens-healthineers-logo-768x180.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/siemens-healthineers-logo-1536x361.webp 1536w\" sizes=\"auto, (max-width: 1919px) 100vw, 1919px\" \/><\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <p><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"373\" class=\"wp-image-6530 aligncenter\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/nordic-logo-scaled.webp\" alt=\"\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/nordic-logo-scaled.webp 2560w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/nordic-logo-300x44.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/nordic-logo-1024x149.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/nordic-logo-768x112.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/nordic-logo-1536x224.webp 1536w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/nordic-logo-2048x298.webp 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/p>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Test specifications and laboratory capabilities\r\n<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p><em>Test specifications<\/em><\/p>\n<ul>\n<li data-charcodes=\"8226\" data-buautonum=\"8\" data-aria-posinset=\"1\" data-aria-level=\"1\"><em>In-vitro<\/em><span data-contrast=\"auto\">\u00a0diagnostic multivariate index Assay,\u00a0<strong>FDA<\/strong>\u00a0granted De Novo Marketing Authorization<\/span>\u200b<\/li>\n<li data-charcodes=\"8226\" data-buautonum=\"8\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Serum-based assay available at Nordic in the<strong>\u00a0high-<\/strong><\/span><strong>throughput<\/strong><span data-contrast=\"auto\"><strong>\u00a0Attelica IM\u00ae System<\/strong>, under a\u00a0<strong>CAP certified Lab<\/strong>\u00a0and\u00a0<\/span><span data-contrast=\"auto\">and<\/span><span data-contrast=\"auto\">\u00a0enrolled in\u00a0<strong>proficiency testing<\/strong>\u00a0(PT) program\u00a0<\/span>\u200b<\/li>\n<li data-charcodes=\"8226\" data-buautonum=\"8\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\"><strong>Volume required<\/strong>:\u00a0<\/span><span data-contrast=\"auto\"><strong>271 \u00b5l<\/strong>\u00a0<\/span><span data-contrast=\"auto\">Can be run in the same aliquot as PRO-C3, using a combined volume of\u00a0<\/span><strong>362 \u00b5l<\/strong>\u200b<\/li>\n<li data-charcodes=\"8226\" data-buautonum=\"8\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"auto\"><strong>Sample Stability<\/strong>: stable at \u2264 -20\u00b0C for up to 12 months. Stable at \u2264 -70C for three years, according to literature<\/span><\/li>\n<\/ul>\n<p><em>Laboratory capabilities\u200b<\/em><\/p>\n<ul>\n<li data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559683&quot;:0,&quot;335559685&quot;:0,&quot;335559731&quot;:0,&quot;335559737&quot;:0,&quot;335562764&quot;:2,&quot;335562765&quot;:1,&quot;335562766&quot;:4,&quot;335562767&quot;:0,&quot;335562768&quot;:4,&quot;335562769&quot;:0}\"><strong>Bi-weekly testing<\/strong>\u00a0frequency\u200b<\/li>\n<li data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559683&quot;:0,&quot;335559685&quot;:0,&quot;335559731&quot;:0,&quot;335559737&quot;:0,&quot;335562764&quot;:2,&quot;335562765&quot;:1,&quot;335562766&quot;:4,&quot;335562767&quot;:0,&quot;335562768&quot;:4,&quot;335562769&quot;:0}\">\u200b<strong>Batch-testing and on-demand testing<\/strong>\u00a0available\u200b<\/li>\n<li data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559683&quot;:0,&quot;335559685&quot;:0,&quot;335559731&quot;:0,&quot;335559737&quot;:0,&quot;335562764&quot;:2,&quot;335562765&quot;:1,&quot;335562766&quot;:4,&quot;335562767&quot;:0,&quot;335562768&quot;:4,&quot;335562769&quot;:0}\">\u200b<span class=\"TextRun SCXP36522597 BCX8\" xml:lang=\"EN-US\" data-scheme-color=\"@002060,,\" data-usefontface=\"true\" data-contrast=\"none\"><span class=\"NormalTextRun SCXP36522597 BCX8\">Turn-around time up to three\u00a0<\/span><\/span><span class=\"TextRun SCXP36522597 BCX8\" xml:lang=\"EN-US\" data-scheme-color=\"@002060,,\" data-usefontface=\"true\" data-contrast=\"none\"><span class=\"NormalTextRun SCXP36522597 BCX8\">working days*<\/span><\/span><\/li>\n<li data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559683&quot;:0,&quot;335559685&quot;:0,&quot;335559731&quot;:0,&quot;335559737&quot;:0,&quot;335562764&quot;:2,&quot;335562765&quot;:1,&quot;335562766&quot;:4,&quot;335562767&quot;:0,&quot;335562768&quot;:4,&quot;335562769&quot;:0}\"><span class=\"EOP SCXP36522597 BCX8\"><span class=\"TextRun BCX8 SCXP153252768\" xml:lang=\"EN-US\" data-scheme-color=\"@002060,,\" data-usefontface=\"true\" data-contrast=\"none\"><span class=\"NormalTextRun BCX8 SCXP153252768\">Reported as Data transfer, Remote\u00a0<\/span><\/span><span class=\"TextRun BCX8 SCXP153252768\" xml:lang=\"EN-US\" data-scheme-color=\"@002060,,\" data-usefontface=\"true\" data-contrast=\"none\"><span class=\"NormalTextRun BCX8 SCXP153252768\">Lab-integration (RLI) or as individual\u00a0<\/span><\/span><span class=\"TextRun BCX8 SCXP153252768\" xml:lang=\"EN-US\" data-scheme-color=\"@002060,,\" data-usefontface=\"true\" data-contrast=\"none\"><span class=\"NormalTextRun BCX8 SCXP153252768\">Lab reports*<\/span><\/span><\/span><\/li>\n<\/ul>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"mailto:djl@nordicbio.com?cc=rve@nordicbio.com&#038;subject=Biomarkers%20in%20hepatic%20diseases%20\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"_blank\">\n            Interested to learn more? 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