{"id":743,"date":"2025-01-22T11:38:16","date_gmt":"2025-01-22T11:38:16","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker-solutions&#038;p=743"},"modified":"2025-06-01T08:35:58","modified_gmt":"2025-06-01T08:35:58","slug":"masld-sld-and-mash","status":"publish","type":"biomarker-solution","link":"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/masld-sld-and-mash\/","title":{"rendered":"MASLD, SLD, and MASH"},"content":{"rendered":"<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Biomarkers in steatotic liver disease (MASLD, SLD)<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>There is a pressing requirement for new, non-invasive tools to assess the severity of metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as\u00a0non-alcoholic fatty liver disease (NAFLD), worldwide. These tools would aid in monitoring patient progression and stratifying risk for this increasingly prevalent condition.<\/p>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/technology\/nordic-proteinfingerprint-technology\/\">Nordic Bioscience has developed biomarkers<\/a> that specifically focus on the progression of\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/end-stage-liver-disease\/\" target=\"_blank\" rel=\"noopener noreferrer\">liver fibrosis<\/a>. These biomarkers offer a unique approach to determining the trajectory of patients with MASLD. They can be used to stratify patients based on their risk levels, assess the effectiveness of pharmacological treatments, and enhance the selection of participants for clinical trials, ultimately improving the chances of successful outcomes.<\/p>\n                <\/div>\n                                    <div class=\"mt-8 mb-4 xl:mb-8 links\">\n                        <h3 class=\"mb-2 text-blue group-[.dark]:text-fontlight text-body-sm\">Publications<\/h3>\n                        <ul class=\"flex flex-wrap gap-2\">\n                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=%22fatty%20liver%20disease%22\" target=\"_blank\">MAFLD<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=mash\" target=\"_blank\">MASH<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=nash\" target=\"_blank\">NASH<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=nafld\" target=\"_blank\">NAFLD<\/a>\n                                    <\/li>\n                                                                                    <\/ul>\n                    <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/nash_-webp-1.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Nordic ProteinFingerPrint Technology\u2122 biomarkers in MASLD<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a condition related to the metabolic syndrome that affects the liver. One of the key factors in determining the prognosis of MASLD is the extent of liver fibrosis, which involves the accumulation of components like collagens in the liver tissue. <a href=\"https:\/\/www.nordicbioscience.com\/about\/blog-and-resources\/resources\/why-measure-the-right-epitope-of-the-right-protein\" target=\"_blank\" rel=\"noopener noreferrer\">Nordic Bioscience&#8217;s biomarkers specifically target certain neo-epitopes\u00a0of collagen fragments<\/a> involved in formation and degradation, which can be detected directly in blood samples.<\/p>\n<p>By using biomarkers that target different types of collagens in the liver, it is possible to determine the origin of the fibrotic tissue being formed and understand the dynamics driving disease progression, such as pericellular fibrosis (involving basement membrane collagens) or bridging fibrosis (involving fibrillar collagens).<\/p>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/hepatic-diseases\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"_blank\">\n            Browse our liver biomarker portfolio            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/shutterstock-2162135319-scaled.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2>NordicPRO-C3\u2122 is a stellar example of a liver-related biomarker<\/h2>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/products\/biomarkers\/pro-c3\" target=\"_blank\" rel=\"noopener noreferrer\">NordicPRO-C3\u2122<\/a>\u00a0is our most widely applied biomarker and has received a letter of support from the FDA for its application in liver disease.\u00a0NordicPRO-C3\u2122 is very well suited for evaluating ongoing fibrogenesis in patients with advanced fibrosis, stages F3-F4<sup>[<a title=\"Daniels et al. Hepatology (2019)\" href=\"https:\/\/aasldpubs.onlinelibrary.wiley.com\/doi\/full\/10.1002\/hep.30163\" target=\"_blank\" rel=\"noopener noreferrer\">1<\/a>]<\/sup>. However, we recommend also assessing fibrolysis (<a href=\"https:\/\/www.nordicbioscience.com\/products\/biomarkers\/c3m\">C3M<\/a>,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/products\/biomarkers\/c4m\" target=\"_blank\" rel=\"noopener noreferrer\">C4M<\/a>,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/products\/biomarkers\/c6m\" target=\"_blank\" rel=\"noopener noreferrer\">C6M<\/a>), pericellular fibrosis (<a href=\"https:\/\/www.nordicbioscience.com\/products\/biomarkers\/pro-c4\" target=\"_blank\" rel=\"noopener noreferrer\">PRO-C4<\/a>,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/products\/biomarkers\/pro-c8\" target=\"_blank\" rel=\"noopener noreferrer\">PRO-C8<\/a>), and fibrosis resolution (<a href=\"https:\/\/www.nordicbioscience.com\/products\/biomarkers\/ctx-iii\" target=\"_blank\" rel=\"noopener noreferrer\">CTX-III<\/a>) to evaluate potential treatment effect on all aspects of fibrosis activity in the liver (Figure 1).<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure><\/figure>\n<p>&nbsp;<\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-webp-scaled.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6585\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-webp-scaled.webp\" alt=\"\" width=\"2560\" height=\"878\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-webp-scaled.webp 2560w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-webp-300x103.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-webp-1024x351.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-webp-768x263.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-webp-1536x527.webp 1536w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-webp-2048x703.webp 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/a><figcaption class=\"wp-element-caption\"><strong><em>Figure 1.\u00a0<\/em><\/strong><em>NordicPRO-C3\u2122\u00a0increases with increasing fibrosis and MASLD activity score (NAS).<\/em><\/figcaption><\/figure>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n<section class=\"call-to-action\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col\">\n        <article style=\"background-image: url(https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/04\/lila-2-webp-1024x682.webp)\" class=\"bg-cover shadow-main flex overflow-clip flex-col justify-between px-5 py-10 rounded-md bg-gray-600 xl:p-40 text-column xl:rounded-xl after:content-[''] after:block after:inset-0 relative after:absolute after:bg-gradient-to-b from-black\/0 to-black\">\n            <div class=\"max-w-[900px] mx-auto relative z-10\">\n                <div class=\"text-center text-balance\">\n                     \n                    <\/div>\n                    <div class=\"mb-8 text-center !text-fontlight\/90 body-text text-balance\">\n                                            <\/div>\n                    \n                    \n                    <div class=\"flex flex-col items-center w-full gap-4 md:gap-6 xl:mt-8 xl:flex-row xl:justify-center group light-button\">\n                                                                                    <div class=\"w-full text-center md:w-auto\">\n\n                                            <a href=\"mailto:bd@nordicbioscience.com?subject=General%20Inquiry\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Interested to learn more? Reach out!            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                    <\/div>\n                                                                                            <\/div>\n                                                    <\/div>\n                    <\/article>\n                <\/div>\n            <\/section>\n\n\n<section class=\"one-column-block bg-grey py-10\">\n<div class=\"inner xl:p-10 xl:pt-20 xl:pb-20 lg:p-8 p-5 max-w-[1440px] mx-auto\">\n\n        <div class=\"max-w-[900px] mx-auto wysiwyg\">\n            <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">ADAPT: NordicPRO-C3\u2122-based algorithm for accurate identification of advanced fibrosis in MASLD<\/h2>\n            <p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/nordic-pro-c3\/\">NordicPRO-C3\u2122<\/a>, a diagnostic tool, possesses the capability to accurately identify individuals with both MASH (Metabolic Associated Steatohepatitis) and <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/end-stage-liver-disease\/\">liver fibrosis<\/a> who qualify for participation in clinical trials<sup>[<a title=\"Erhardtsen et al., 2021\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34466796\/\" target=\"_blank\" rel=\"noopener noreferrer\">2<\/a>,<a title=\"Nielsen et al., 2021\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34454994\/\" target=\"_blank\" rel=\"noopener noreferrer\">3<\/a>]<\/sup>.<\/p>\n<p>Its effectiveness is further enhanced when integrated into the ADAPT algorithm<sup>[<a title=\"Daniels et al., 2019\" href=\"https:\/\/aasldpubs.onlinelibrary.wiley.com\/doi\/full\/10.1002\/hep.30163\" target=\"_blank\" rel=\"noopener noreferrer\">4<\/a>]<\/sup>, a comprehensive scoring system that factors in age, platelet count, and the presence of diabetes. Remarkably, ADAPT demonstrates superior predictive accuracy compared to other existing scoring systems when it comes to forecasting advanced fibrosis and MASH, as indicated by the research by Erhardtsen (2021).<\/p>\n<p>Notably, ADAPT surpasses alternative fibrosis scoring methods such as the aspartate aminotransferase to platelet ratio index (APRI), FIB-4, and the NAFLD fibrosis score (NFS) in the identification of significant fibrosis (F2-F4) in individuals afflicted with MASLD (Metabolic Associated Steatohepatitis Liver Disease)<sup>[<a title=\"Daniels et al., 2019\" href=\"https:\/\/aasldpubs.onlinelibrary.wiley.com\/doi\/full\/10.1002\/hep.30163\" target=\"_blank\" rel=\"noopener noreferrer\">4<\/a>]<\/sup>.<\/p>\n<p><!-- wp:image {\"id\":5794,\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/100-specificity.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-5794\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/100-specificity.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/100-specificity.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/100-specificity-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/100-specificity-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/100-specificity-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 2<\/strong>. ADAPT is superior to existing fibrosis scores<\/em><\/figcaption><\/figure>\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2 class=\"block-fc\">NordicPRO-C3\u2122 as a secondary endpoint for antifibrotic efficacy<\/h2>\n<p class=\"has-text-align-left\">In a phase II study conducted by Madrigal Pharmaceuticals, it was observed that patients who were administered Resmetirom experienced notable reductions in\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\u00a0and MRI-PDFF levels<sup>[<a href=\"https:\/\/aasldpubs.onlinelibrary.wiley.com\/doi\/full\/10.1002\/hep4.1657\" target=\"_blank\" rel=\"noreferrer noopener\">5<\/a>]<\/sup>.<\/p>\n<p class=\"has-text-align-left\">This study involved patients who were initially divided into two groups: one receiving a placebo (Pbo) and the other receiving Resmetirom (Res) for a duration of 36 weeks. Subsequently, all participants continued with Resmetirom in the open-label extension (OLE) trial for an additional 36 weeks (Figure 3).<\/p>\n<p>&nbsp;<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/res.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-5796\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/res.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/res.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/res-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/res-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/res-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 3.<\/strong> NordicPRO-C3\u2122 is used as a determinant of treatment efficacy in multiple clinical trials as a secondary endpoint for antifibrotic efficacy<\/em><\/figcaption><\/figure>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-disease-activity-endotyping-nordic-bioscience.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-748\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-disease-activity-endotyping-nordic-bioscience.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-disease-activity-endotyping-nordic-bioscience.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-disease-activity-endotyping-nordic-bioscience-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-disease-activity-endotyping-nordic-bioscience-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-disease-activity-endotyping-nordic-bioscience-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 4.<\/strong> NordicPRO-C3\u2122\u00a0as a baseline marker of disease activity and endotyping<br \/>\n<\/em><\/figcaption><\/figure>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2>NordicPRO-C3\u2122 as a baseline marker of disease activity and endotyping<\/h2>\n<p class=\"has-text-align-left\">Harrison et al. demonstrated at EASL 2018 that patients with\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\u00a0greater than or equal to 17.5 ng\/mL had a significant reduction in their\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\u00a0level due to Resmetirom (a selective thyroid hormone receptor-\u03b2 agonist) treatment.<\/p>\n<p>Similar predictive results for Resmetirom were presented by Madrigal Pharmaceuticals at Global NASH Congress 2020 in the extension study when using a baseline level of \u226514 ng\/mL nordicPRO-C3\u2122.<\/p>\n<p class=\"has-text-align-left\">Consequently,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">nordicPRO-C3\u2122<\/a>\u00a0levels &gt;14 ng\/mL have been listed as inclusion criteria for the phase III MASH (metabolic dysfunction-associated steatohepatitis) clinical trial MAESTRO-NASH (NCT03900429).<\/p>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--80)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/hepatic-diseases\/\">Find biomarkers for liver indications<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--80)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"accordion-block\">\n    <div class=\"inner xl:p-10 lg:p-8 lg:pb-0 xl:pb-0 p-5 pb-0 max-w-[1440px] mx-auto\">\n        <div>\n                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg text-navy\">About MASLD (formerly NAFLD)<\/h2>\n         \n        <\/div>\n            <ul class=\"accordion\">\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"1\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What is MASLD  (formerly NAFLD)?<\/span>\n                        <span id=\"icon-1\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-1\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a chronic condition that affects approximately 38% of the global population. It is closely linked to metabolic syndrome features such as obesity and type 2 diabetes mellitus.<\/p>\n<p>&nbsp;<\/p>\n<p>MASLD is characterized by the accumulation of fat in the liver and encompasses various disease stages, ranging from simple lipid buildup or steatosis (metabolic dysfunction-associated steatotic liver, MASL) to its inflammatory form known as metabolic dysfunction-associated steatohepatitis (MASH).<\/p>\n<p>&nbsp;<\/p>\n<p>In some instances, persistent MASH can lead to cirrhosis (liver scarring), liver failure, and liver cancer. According to a 2022 report by the World Health Organization, obesity and overweight, which are significant independent risk factors for MASLD, affect nearly 60% of adults and approximately one in three children in Europe.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"2\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">Is MASLD related to liver cancer?<\/span>\n                        <span id=\"icon-2\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-2\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Due to its increasing prevalence, MASLD has become the most common reason for liver transplantation and the primary cause of liver cancer. From a clinical standpoint, the challenge lies in identifying which MASLD patients will progress to cirrhosis, end-stage liver disease, or liver cancer, in order to provide appropriate care.<\/p>\n<p>&nbsp;<\/p>\n<p>Currently, the diagnosis of MASLD necessitates an invasive liver biopsy procedure, limited to specialized hospitals, highlighting the need for improved non-invasive diagnostic tools.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"3\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How can biomarkers help in managing MASLD?<\/span>\n                        <span id=\"icon-3\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-3\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Biomarkers such as NordicPRO-C3\u2122, PRO-C6, and CTX-III provide a non-invasive way to assess liver fibrosis by measuring collagen turnover in the blood. These markers help monitor disease progression, evaluate treatment response, and identify patients at higher risk for advanced fibrosis or MASH.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"4\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What makes NordicPRO-C3\u2122 a key biomarker in MASLD?<\/span>\n                        <span id=\"icon-4\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-4\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>NordicPRO-C3\u2122 measures active fibrogenesis and is supported by the FDA as a biomarker for liver disease. It is particularly useful for identifying patients with advanced fibrosis (F3\u2013F4) and has been used as a secondary endpoint in multiple antifibrotic clinical trials.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"5\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">Can biomarkers improve clinical trial design for MASLD therapies?<\/span>\n                        <span id=\"icon-5\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-5\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Yes, biomarkers like NordicPRO-C3\u2122 are used for patient selection, endotyping, and tracking treatment efficacy. The ADAPT algorithm, which includes PRO-C3, outperforms traditional scores (e.g., FIB-4, NFS) in identifying advanced fibrosis, making it a valuable tool in MASLD clinical research.B<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                    <\/ul>\n    \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col xl:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg 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