{"id":727,"date":"2025-01-22T11:00:44","date_gmt":"2025-01-22T11:00:44","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker-solutions&#038;p=727"},"modified":"2025-06-01T08:38:02","modified_gmt":"2025-06-01T08:38:02","slug":"end-stage-liver-disease","status":"publish","type":"biomarker-solution","link":"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/end-stage-liver-disease\/","title":{"rendered":"End-stage Liver Disease"},"content":{"rendered":"<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">End-stage liver disease biomarkers<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>The current diagnostic methods for end-stage liver disease and cirrhosis often involve invasive procedures and may not offer timely results.\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/blog\/biomarkers-in-drug-development\/\">Blood-based biomarkers\u00a0<\/a>can provide tools to offer immediate treatment to patients with liver failure and identify the potential need for liver transplant by enabling early detection and intervention, leading to improved patient outcomes.\u00a0Such biomarkers could significantly enhance the management and care of patients with chronic liver conditions, offering hope for a better quality of life and reducing the burden on healthcare systems.<\/p>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/technology\/nordic-proteinfingerprint-technology\/\">Nordic Bioscience\u2019s biomarkers<\/a> are designed to\u00a0specifically target the dynamics of collagen deposition, which is the main cause of liver scarring in cirrhosis. These biomarkers offer multiple benefits, including efficient patient stratification for advanced fibrosis (F3-F4), the ability to monitor drug response and pharmacodynamics during clinical trials, and the potential to provide valuable prognostic information for clinical outcomes and mortality in patients with end-stage liver disease.<\/p>\n                <\/div>\n                                    <div class=\"mt-8 mb-4 xl:mb-8 links\">\n                        <h3 class=\"mb-2 text-blue group-[.dark]:text-fontlight text-body-sm\">Publications<\/h3>\n                        <ul class=\"flex flex-wrap gap-2\">\n                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=%22cirrhosis%22\" target=\"_blank\">Cirrhosis<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=%22hepatic%20fibrosis%22\" target=\"_blank\">Hepatic fibrosis<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=%22end-stage%20liver%22\" target=\"_blank\">End-stage liver<\/a>\n                                    <\/li>\n                                                                                    <\/ul>\n                    <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/end-stage-liver-disease-scaled.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Nordic ProteinFingerPrint Technology\u2122 biomarkers in end-stage liver disease<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>End-stage liver disease consists of advanced stages of liver fibrosis (F3-F4) due to chronic damage and scaring resulting in cirrhosis and acute liver failure.<\/p>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/technology\/nordic-proteinfingerprint-technology\/\">Nordic Bioscience developed biomarkers<\/a> based on neo-epitope technology targeting the formation and degradation of collagens by detecting collagen fragments directly in the blood.<\/p>\n<div>Twenty types of collagen have been identified in the liver, and their individual localization and structure reflect their function in the tissue. The interstitial matrix around the portal tract and the central veins is composed of fibrillar collagens such as type I, III and V collagen which provide structural support to the ECM.<\/div>\n<div>\n<p>A fragment originating from the cleavage of type VI collagen alpha3, named\u00a0endotrophin\u00a0(measured by the<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">\u00a0PRO-C6 (nordicPRO-C6\u2122)<\/a>), has an important role for the progression of hepatic fibrosis,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solutions\/metabolic-dysregulation\/\" data-type=\"biomarker-solutions\" data-id=\"781\">adipose tissue dysfunction<\/a>, and insulin resistance.\u00a0Monitoring the levels of these collagen fragments represents a promising diagnostic and prognostic tool for identifying patients with advanced fibrosis and end-stage liver disease.<\/p>\n<p>Explore our end-stage liver disease biomarker portfolio and choose a panel that suits your specific needs for your clinical\/preclinical research or drug development project!<\/p>\n<\/div>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/hepatic-diseases\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"_blank\">\n            Browse our portfolio of liver biomarkers            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/shutterstock-2162135319-scaled.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2>NordicPRO-C3\u2122 based scores for prediction of liver-related events<\/h2>\n<p class=\"has-text-align-left\"><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\u00a0and the ADAPT score exhibit superior performance for the diagnosis of significant and advanced fibrosis when compared to other liver scores.<sup>[<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15595\" target=\"_blank\" rel=\"noreferrer noopener\">1<\/a>]<\/sup>\u00a0The prognostic accuracy of <a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a> can be further improved by incorporating other independent predictors of liver-related events such as platelets and the ratio AST\/ALT into a prediction model named ALPACA.<\/p>\n<p><!-- \/wp:paragraph --><!-- wp:paragraph {\"style\":{\"typography\":{\"fontSize\":\"16px\"}}} -->The <a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>-based ALPACA (0.85) score outperforms FIB-4 (0.78), <a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a> (0.80) and ADAPT (0.81) and, is comparable to ELF (0.83) and TE (0.84) for risk stratification of patients with chronic liver disease due to alcohol overuse (Figure 1).<\/p>\n<p><!-- \/wp:paragraph --><!-- wp:paragraph {\"align\":\"left\",\"style\":{\"typography\":{\"fontSize\":\"16px\"}}} --><\/p>\n<p class=\"has-text-align-left\">The ALPACA score shows superior discriminative performance over time\u00a0for predicting LREs when compared to transient elastography (TE), enhanced liver fibrosis test (ELF), ADAPT, <a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a> and fibrosis-4 index (FIB-4).<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-predicts-liver-related-events-nordic-bioscience.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-732\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-predicts-liver-related-events-nordic-bioscience.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-predicts-liver-related-events-nordic-bioscience.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-predicts-liver-related-events-nordic-bioscience-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-predicts-liver-related-events-nordic-bioscience-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-predicts-liver-related-events-nordic-bioscience-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 1.\u00a0<\/strong>Prediction of LREs using <\/em>PRO-C3 (nordicPRO-C3\u2122)<em> based scores ALPACA and ADAPT in relation to other liver scores.\u00a0ELF, enhanced liver fibrosis test; FIB-4, fibrosis-4 index and nordicPRO-C3\u2122 in a derivation cohort.<sup>[1]<\/sup><\/em><\/figcaption><\/figure>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n<section class=\"one-column-block bg-grey py-10\">\n<div class=\"inner xl:p-10 xl:pt-20 xl:pb-20 lg:p-8 p-5 max-w-[1440px] mx-auto\">\n\n        <div class=\"max-w-[900px] mx-auto wysiwyg\">\n            <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">NordicPRO-C3\u2122 for risk stratification of clinical events in end-stage liver disease<\/h2>\n            <p class=\"has-text-align-left\">The balance between the production and breakdown of type III collagen becomes disrupted in individuals suffering from end-stage liver disease. This imbalance leads to abnormally elevated levels of\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\u00a0and is linked to a heightened risk of liver-related complications in end-stage liver disease patients<sup>[<a href=\"https:\/\/www.jhep-reports.eu\/article\/S2589-5559(23)00074-5\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">2<\/a>]<\/sup>. Notably,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\u00a0proves to be a highly effective predictor of liver-related clinical outcomes in various models of chronic liver injury.<\/p>\n<p class=\"has-text-align-left\">In a specific cohort of patients with compensated cirrhosis, a twofold increase in\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\u00a0levels has been shown to correspond to a 2.7-fold increase in the hazard ratio for the development of liver-related complications.<\/p>\n<p><!-- wp:image {\"id\":733,\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-risk-stratification-end-stage-liver-disease-nordic-bioscience.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-733\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-risk-stratification-end-stage-liver-disease-nordic-bioscience.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-risk-stratification-end-stage-liver-disease-nordic-bioscience.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-risk-stratification-end-stage-liver-disease-nordic-bioscience-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-risk-stratification-end-stage-liver-disease-nordic-bioscience-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/pro-c3-risk-stratification-end-stage-liver-disease-nordic-bioscience-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 2.<\/strong><\/em><strong>\u00a0<\/strong><em>NordicPRO-C3\u2122\u00a0is associated with liver-related outcomes in patients with compensated cirrhosis<sup>[2]<\/sup><\/em><\/figcaption><\/figure>\n<p><!-- \/wp:image --><\/p>\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n<section class=\"call-to-action\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col\">\n        <article style=\"background-image: url(https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/04\/lila-2-webp-1024x682.webp)\" class=\"bg-cover shadow-main flex overflow-clip flex-col justify-between px-5 py-10 rounded-md bg-gray-600 xl:p-40 text-column xl:rounded-xl after:content-[''] after:block after:inset-0 relative after:absolute after:bg-gradient-to-b from-black\/0 to-black\">\n            <div class=\"max-w-[900px] mx-auto relative z-10\">\n                <div class=\"text-center text-balance\">\n                     \n                    <\/div>\n                    <div class=\"mb-8 text-center !text-fontlight\/90 body-text text-balance\">\n                                            <\/div>\n                    \n                    \n                    <div class=\"flex flex-col items-center w-full gap-4 md:gap-6 xl:mt-8 xl:flex-row xl:justify-center group light-button\">\n                                                                                    <div class=\"w-full text-center md:w-auto\">\n\n                                            <a href=\"mailto:bd@nordicbioscience.com?subject=General%20Inquiry\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Interested to learn more? Reach out!            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                    <\/div>\n                                                                                            <\/div>\n                                                    <\/div>\n                    <\/article>\n                <\/div>\n            <\/section>\n\n\n<section class=\"one-column-block bg-grey py-10\">\n<div class=\"inner xl:p-10 xl:pt-20 xl:pb-20 lg:p-8 p-5 max-w-[1440px] mx-auto\">\n\n        <div class=\"max-w-[900px] mx-auto wysiwyg\">\n            <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Prognostic value of biomarkers of ECM turnover in cirrhosis<\/h2>\n            <p class=\"has-text-align-left\">Patients with acute-on-chronic liver failure (ACLF) exhibit short-term mortality and deranged inflammatory responses. ECM biomarkers have a critical role in regulating inflammatory responses and were found to be altered in patients with acute decompensation and ACLF. Elevated\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">PRO-C6 (nordicPRO-C6\u2122)<\/a>\u00a0levels in patients with ACFL showed a strong association to inflammatory markers, liver function, organ injury and failure, mortality and outcomes.<sup>[<a href=\"https:\/\/www.jhep-reports.eu\/article\/S2589-5559(21)00131-2\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">3<\/a>]<\/sup><\/p>\n<p class=\"has-text-align-left\">Plasma levels of\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">PRO-C6 (nordicPRO-C6\u2122)<\/a>\u00a0are increased in patients with ACFL in comparison to acute decompensation (AD), stable cirrhosis (SC) and healthy controls (HC). High vs low levels of\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>and\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">PRO-C6 (nordicPRO-C6\u2122)<\/a>\u00a0can be used for stratification of patients according to 28-day-transplant-free survival and 90-day-transplant-free survival, respectively.<\/p>\n<p><!-- wp:image {\"id\":734,\"sizeSlug\":\"full\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/prognostic-biomarkers-end-stage-liver-disease-nordic-bioscience2.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-734\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/prognostic-biomarkers-end-stage-liver-disease-nordic-bioscience2.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/prognostic-biomarkers-end-stage-liver-disease-nordic-bioscience2.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/prognostic-biomarkers-end-stage-liver-disease-nordic-bioscience2-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/prognostic-biomarkers-end-stage-liver-disease-nordic-bioscience2-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/prognostic-biomarkers-end-stage-liver-disease-nordic-bioscience2-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 3.\u00a0<\/strong>NordicPRO-C3\u2122and nordicPRO-C6\u2122 plasma levels and association to clinical outcomes<sup>[3]<\/sup><\/em><\/figcaption><\/figure>\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2>Prediction of fibrosis recurrence after liver transplantation<\/h2>\n<p class=\"has-text-align-left\">The recurrence of cirrhosis after liver transplantation occurs in approximately 10-30% of the patients. Therefore, it is extremely necessary to use non-invasive tests to detect the development of early fibrosis after liver transplantation without the need for a liver biopsy. ECM markers overperform the commonly used liver scores such as APRI and FIB-4 in identifying graft fibrosis following liver transplantation<sup>[<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-33100-7\" target=\"_blank\" rel=\"noreferrer noopener\">4<\/a>]<\/sup>.<\/p>\n<p>Markers of formation of type III (<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>; interstitial matrix) and formation\/degradation of type IV collagen (<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c4\/\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"biomarker\" data-id=\"1133\">PRO-C4<\/a>\/<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/c4m\/\" data-type=\"biomarker\" data-id=\"957\">C4M;<\/a>\u00a0basement membrane) can be measured in serum and help to identify intermediate and fast progressors in fibrosis after liver transplantation.<sup>[<a href=\"https:\/\/www.nature.com\/articles\/s41598-019-51394-4\" target=\"_blank\" rel=\"noreferrer noopener\">5<\/a>]<\/sup><\/p>\n<p class=\"has-text-align-left\">Plasma levels of\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">PRO-C6 (nordicPRO-C6\u2122)<\/a>\u00a0are increased in patients with ACFL in comparison to acute decompensation (AD), stable cirrhosis (SC) and healthy controls (HC). High vs low levels of\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">PRO-C3 (nordicPRO-C3\u2122)<\/a>and\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" data-type=\"biomarker\" data-id=\"1137\">PRO-C6 (nordicPRO-C6\u2122)<\/a>\u00a0can be used for stratification of patients according to 28-day-transplant-free survival and 90-day-transplant-free survival, respectively (Figure 3.)<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure><\/figure>\n<p>&nbsp;<\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-recurrence-prediction-liver-transplantation-nordic-bioscience.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-730\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-recurrence-prediction-liver-transplantation-nordic-bioscience.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-recurrence-prediction-liver-transplantation-nordic-bioscience.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-recurrence-prediction-liver-transplantation-nordic-bioscience-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-recurrence-prediction-liver-transplantation-nordic-bioscience-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/fibrosis-recurrence-prediction-liver-transplantation-nordic-bioscience-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 4.\u00a0<\/strong>PRO-C4, C4M and nordicPRO-C3\u2122 predictive value<sup>[4]<\/sup><\/em><\/figcaption><\/figure>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/hepatic-diseases\/\">Find biomarkers for liver indications<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--80)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"accordion-block\">\n    <div class=\"inner xl:p-10 lg:p-8 lg:pb-0 xl:pb-0 p-5 pb-0 max-w-[1440px] mx-auto\">\n        <div>\n                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg text-navy\">About end-stage liver disease<\/h2>\n         \n        <\/div>\n            <ul class=\"accordion\">\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"1\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What is end-stage liver disease?<\/span>\n                        <span id=\"icon-1\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-1\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>The term &#8220;end-stage liver disease&#8221; refers to the advanced stages of liver fibrosis (F3-F4) caused by chronic damage and scarring, ultimately resulting in cirrhosis and, in some cases, acute liver failure.<\/p>\n<p>&nbsp;<\/p>\n<p>During this stage, there is a significant accumulation of extracellular matrix (ECM) components, particularly collagens, which contribute to the development of severe fibrosis.<\/p>\n<p>&nbsp;<\/p>\n<p>This excessive deposition of collagens hinders the liver&#8217;s ability to regenerate properly, leading to impaired liver function and the onset of various complications, including cirrhosis and potentially liver cancer (hepatocellular carcinoma).<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"2\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">Why is end-stage liver disease life-threatening?<\/span>\n                        <span id=\"icon-2\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-2\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Clinically, end-stage liver disease poses a significant threat to the patient&#8217;s overall health and can lead to life-threatening conditions.<\/p>\n<p>&nbsp;<\/p>\n<p>The liver&#8217;s vital functions, such as detoxification, metabolism, and synthesis of essential proteins, are severely compromised.<\/p>\n<p>&nbsp;<\/p>\n<p>As a result, patients may experience symptoms like jaundice, ascites (fluid accumulation in the abdomen), hepatic encephalopathy (brain dysfunction due to liver failure), and gastrointestinal bleeding.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"3\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How to manage end-stage liver disease patients?<\/span>\n                        <span id=\"icon-3\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-3\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Timely diagnosis and proper management of end-stage liver disease are crucial for improving patient outcomes.<\/p>\n<p>&nbsp;<\/p>\n<p>Treatment options may include lifestyle modifications, medications to manage symptoms and complications, and in some cases, liver transplantation as a definitive therapy for selected patients.<\/p>\n<p>&nbsp;<\/p>\n<p>Regular monitoring and follow-up with healthcare providers are essential to assess disease progression and optimize the patient&#8217;s treatment plan<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"4\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How can biomarkers support early detection and risk stratification in liver cirrhosis?<\/span>\n                        <span id=\"icon-4\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-4\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"445\" data-end=\"805\">By measuring collagen turnover, biomarkers like PRO-C3 can identify patients at risk of liver-related events before symptoms worsen. These markers help stratify patients by fibrosis stage (F3\u2013F4) and support timely decisions around treatment or transplant evaluation.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"5\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What is the ALPACA score and how does it improve prediction in liver disease?<\/span>\n                        <span id=\"icon-5\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-5\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"807\" data-end=\"1177\">The ALPACA score combines NordicPRO-C3\u2122 with routine clinical parameters to predict liver-related events more accurately than traditional scores like FIB-4 or NAFLD fibrosis score. It enhances prognostic value in patients with chronic liver disease, including alcohol-related cirrhosis.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"6\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">Can biomarkers be used after liver transplantation?<\/span>\n                        <span id=\"icon-6\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-6\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"1179\" data-end=\"1466\">Yes, biomarkers such as PRO-C3 and PRO-C4 can detect early signs of fibrosis recurrence post-transplant. These non-invasive tools help identify patients at risk of rapid disease progression without the need for repeated biopsies.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                    <\/ul>\n    \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col xl:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg group-[.white]:text-navy 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