{"id":721,"date":"2025-01-21T17:31:23","date_gmt":"2025-01-21T17:31:23","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker-solutions&#038;p=721"},"modified":"2025-08-22T13:37:46","modified_gmt":"2025-08-22T13:37:46","slug":"alcohol-related-liver-disease-ald","status":"publish","type":"biomarker-solution","link":"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/alcohol-related-liver-disease-ald\/","title":{"rendered":"Alcohol-related Liver Disease"},"content":{"rendered":"<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Biomarkers in alcohol-related liver disease (ALD)<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <div class=\"blog-item\">\n<div class=\"container-fluid container-master\">\n<div class=\"block block-mb-negative block-imgs-fg block-grid block-theme-blue block-v-sm text-left fancyfake-item\">\n<div class=\"row mx-0\">\n<div class=\"col-12 col-lg-6 px-0\">\n<div class=\"block-content\">\n<p>The development and increase in liver fibrosis is a key component of alcohol-related liver disease (ALD), formerly known as alcoholic liver disease (ALD). This progression can result in cirrhosis or further develop into hepatocellular carcinoma and increased mortality. Patient monitoring using fibrosis biomarkers in ALD patients represents a potential novel diagnostic and disease management tool.<\/p>\n<p>Nordic Bioscience&#8217;s non-invasive biomarkers based on extracellular matrix (ECM) remodeling can help to overcome the challenges in diagnosing ALD and finding patients at high risk of disease progression. Furthermore,\u00a0the use of predictive or prognostic biomarkers of the ECM\u00a0to enrich or stratify patients likely to respond to a therapeutic in drug development trials may reduce the trial length, and size required to determine therapeutic efficacy.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n                <\/div>\n                                    <div class=\"mt-8 mb-4 xl:mb-8 links\">\n                        <h3 class=\"mb-2 text-blue group-[.dark]:text-fontlight text-body-sm\">Publications<\/h3>\n                        <ul class=\"flex flex-wrap gap-2\">\n                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=%22ald%22\" target=\"\">ALD<\/a>\n                                    <\/li>\n                                                                                    <\/ul>\n                    <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/ald-block-side-649ad4c594b67.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Nordic ProteinFingerPrint Technology\u2122 alcohol-related liver disease biomarkers<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <div class=\"blog-item\">\n<div class=\"container-fluid container-master\">\n<div class=\"block block-mb-negative block-imgs-fg block-grid block-theme-blue block-v-sm text-left fancyfake-item\">\n<div class=\"row mx-0\">\n<div class=\"col-12 col-lg-6 px-0\">\n<div class=\"block-content\">\n<p>The hepatic\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/blog\/extracellular-matric-animation\/\">extracellular matrix (ECM)<\/a>\u00a0is rich in different collagens, proteoglycans, and matricellular proteins. In alcohol-related liver disease, the disruption of the balance between degradation and formation of collagens results in ECM remodeling with net formation (build-up and scar formation) of the tissue.<\/p>\n<p>We have identified twenty types of collagens of relevance for liver health. These collagens have different structures and are distributed in different compartments of the ECM, therefore, have specific functions in the tissue.<\/p>\n<p>The dynamics of collagen turnover in alcohol-related liver fibrosis can be investigated using our biomarkers for the formation (<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" target=\"_blank\" rel=\"noreferrer noopener\">nordicPRO-C3\u2122<\/a>,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c4\/\" target=\"_blank\" rel=\"noreferrer noopener\">PRO-C4<\/a>,\u00a0PRO-C5,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" target=\"_blank\" rel=\"noreferrer noopener\">nordicPRO-C6\u2122<\/a>) and degradation (<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/c3m\/\" data-type=\"biomarker\" data-id=\"940\">C3M<\/a>,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/c4m\/\" target=\"_blank\" rel=\"noreferrer noopener\">C4M<\/a>,\u00a0C5M, and\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/products\/biomarkers\/c6m\" target=\"_blank\" rel=\"noreferrer noopener\">C6M<\/a>) of collagens<sup>[<a href=\"https:\/\/www.nordicbioscience.com\/publications\/progressive-alcohol-related-liver-fibrosis-is-characterised-by-imbalanced-collagen-formation-and-degradation\" target=\"_blank\" rel=\"noreferrer noopener\">1<\/a>]<\/sup><em>.<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/hepatic-diseases\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"_blank\">\n            Browse our portfolio of liver biomarkers            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/05\/nordic_bio32884.jpg\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2 class=\"block-fc\">Clinical research value of ALD with nordicPRO-C3\u2122, nordicPRO-C6\u2122 and C4M<\/h2>\n<p>Collagen formation of the interstitial matrix quantified by type III (<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" target=\"_blank\" rel=\"noreferrer noopener\">nordicPRO-C3\u2122<\/a>) and VI (<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\" target=\"_blank\" rel=\"noreferrer noopener\">nordicPRO-C6\u2122<\/a>) collagens formation is elevated in ALD patients compared to healthy subjects (Ctrl).<\/p>\n<p>The basement membrane is further dysregulated in favor of degradation as seen by type IV collagen degradation (<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/c4m\/\">C4M<\/a>) elevated in ALD patients (Figure 1).<\/p>\n<p>This heightened collagen formation in ALD patients suggests an ongoing tissue remodeling process within the interstitial matrix. This dysregulation of the basement membrane, characterized by elevated levels of type IV collagen degradation, underscores the complex interplay between collagen synthesis and degradation that contributes to the pathophysiology of ALD.<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/alcohol-related-liver-disease-biomarkers-nordic-bioscience-1.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-5331\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/alcohol-related-liver-disease-biomarkers-nordic-bioscience-1.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/alcohol-related-liver-disease-biomarkers-nordic-bioscience-1.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/alcohol-related-liver-disease-biomarkers-nordic-bioscience-1-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/alcohol-related-liver-disease-biomarkers-nordic-bioscience-1-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/alcohol-related-liver-disease-biomarkers-nordic-bioscience-1-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><strong><em>Figure 1. <\/em><\/strong><em>nordicPRO-C3\u2122, nordicPRO-C6\u2122, C4M clinical research\u00a0value, as presented at EASL 2019 by the GALAXY consortium<\/em><\/figcaption><\/figure>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n<section class=\"call-to-action\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col\">\n        <article style=\"background-image: url(https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/04\/lila-2-webp-1024x682.webp)\" class=\"bg-cover shadow-main flex overflow-clip flex-col justify-between px-5 py-10 rounded-md bg-gray-600 xl:p-40 text-column xl:rounded-xl after:content-[''] after:block after:inset-0 relative after:absolute after:bg-gradient-to-b from-black\/0 to-black\">\n            <div class=\"max-w-[900px] mx-auto relative z-10\">\n                <div class=\"text-center text-balance\">\n                     \n                    <\/div>\n                    <div class=\"mb-8 text-center !text-fontlight\/90 body-text text-balance\">\n                                            <\/div>\n                    \n                    \n                    <div class=\"flex flex-col items-center w-full gap-4 md:gap-6 xl:mt-8 xl:flex-row xl:justify-center group light-button\">\n                                                                                    <div class=\"w-full text-center md:w-auto\">\n\n                                            <a href=\"mailto:bd@nordicbioscience.com?subject=General%20Inquiry\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Interested to learn more? Reach out!            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                    <\/div>\n                                                                                            <\/div>\n                                                    <\/div>\n                    <\/article>\n                <\/div>\n            <\/section>\n\n\n<section class=\"one-column-block bg-grey py-10\">\n<div class=\"inner xl:p-10 xl:pt-20 xl:pb-20 lg:p-8 p-5 max-w-[1440px] mx-auto\">\n\n        <div class=\"max-w-[900px] mx-auto wysiwyg\">\n            <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Biomarkers of portal hypertension in ALD<\/h2>\n            <p>ALD patients suffering from portal hypertension, measured by Hepatic venous pressure gradient (HPVG), have elevated levels of both formation and degradations biomarkers. This includes basement membrane (type IV collagen; <a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c4\/\" data-type=\"biomarker\" data-id=\"1133\">PRO-C4<\/a>) and interstitial matrix (type III collagens; <a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3\/\" data-type=\"biomarker\" data-id=\"1083\">nordicPRO-C3\u2122<\/a>, type V collagen; C5M, Elastin;\u00a0ELM) proteins (Figure 2.)<\/p>\n<p><!-- wp:image {\"lightbox\":{\"enabled\":true},\"id\":724,\"sizeSlug\":\"large\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/biomarkers-portal-hypertension-ald-nordic-bioscience-scaled.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-724\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/biomarkers-portal-hypertension-ald-nordic-bioscience-1024x322.webp\" alt=\"\" width=\"1024\" height=\"322\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/biomarkers-portal-hypertension-ald-nordic-bioscience-1024x322.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/biomarkers-portal-hypertension-ald-nordic-bioscience-300x94.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/biomarkers-portal-hypertension-ald-nordic-bioscience-768x241.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/biomarkers-portal-hypertension-ald-nordic-bioscience-1536x483.webp 1536w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/biomarkers-portal-hypertension-ald-nordic-bioscience-2048x643.webp 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 2<\/strong>. Formation and degradation biomarkers in alcoholic liver disease (ALD)<sup>[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3935409\/\" target=\"_blank\" rel=\"noreferrer noopener\">2<\/a>]<\/sup><\/em><\/figcaption><\/figure>\n<p><!-- \/wp:image --><\/p>\n<p>Nordic Bioscience&#8217;s biomarkers\u00a0can be used to assess\u00a0ALD\u00a0severity by helping to identify patients with advanced fibrosis and to monitor\u00a0the\u00a0response to treatment and drug\u00a0efficacy.\u00a0We are happy to have our team of scientists\u00a0discuss and understand your aims\u00a0to select the most appropriate biomarkers that can help answer your research questions.<\/p>\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Prognostic value and prediction of outcomes in ALD<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <div class=\"page-header page-header-custom-default\">\n<p class=\"block-fc\"><a style=\"font-size: 16px;\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/nordic-pro-c3\/\">NordicPRO-C3\u2122<\/a><span style=\"font-size: 16px;\"> and <\/span><a style=\"font-size: 16px;\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c6\/\">nordicPRO-C6\u2122<\/a><span style=\"font-size: 16px;\"> provide insights into the liver function of ALD patients and nordicPRO-C3\u2122 has prognostic value for predicting outcomes and liver-related events (LRE) in patients with ALD.<\/span><\/p>\n<\/div>\n<p>NordicPRO-C3\u2122 showed prediction value to identify which patients from a mixed-etiology cohort composed of patients with chronic hepatitis virus and compensated cirrhosis with or without a history of acute alcohol consumption (ALD) are at risk of liver-related outcomes<sup>[<a title=\"Nielsen et al., 2022\" href=\"https:\/\/www.jhep-reports.eu\/action\/showPdf?pii=S2589-5559%2823%2900074-5\" target=\"_blank\" rel=\"noopener noreferrer\">3<\/a>]<\/sup>.<\/p>\n<p>As part of the\u00a0<a href=\"https:\/\/www.sdu.dk\/en\/forskning\/galaxy\" target=\"_blank\" rel=\"noopener noreferrer\">GALAXY consortium<\/a>, a\u00a0prediction model was developed<sup>[<a title=\"Johansen et al., 2022\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/liv.15595\" target=\"_blank\" rel=\"noopener noreferrer\">4<\/a>]<\/sup>\u00a0based on nordicPRO-C3\u2122 and independent predictors of LREs (platelets, AST\/ALT) named ALPACA score which presented a superior prognostic performance for predicting LREs when compared to other liver scores currently used in the clinic such as <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/enhanced-liver-fibrosis-elf-test\/\">ELF<\/a>, TE, and FIB-4, see reference. With the ALPACA score, it was possible to differentiate between patients with a low and high risk of LREs.<\/p>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/hepatic-diseases\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"_blank\">\n            Browse our liver biomarkers            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/shutterstock-2162135319-scaled.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"accordion-block\">\n    <div class=\"inner xl:p-10 lg:p-8 lg:pb-0 xl:pb-0 p-5 pb-0 max-w-[1440px] mx-auto\">\n        <div>\n                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg text-navy\">About alcohol-related liver disease<\/h2>\n         \n        <\/div>\n            <ul class=\"accordion\">\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"1\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What is alcohol-related liver disease?<\/span>\n                        <span id=\"icon-1\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-1\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Alcohol-related liver disease (ALD), formerly known as\u00a0alcoholic liver disease, is a generic term for liver damage caused by chronic alcohol abuse. Prolonged excessive alcohol consumption can impair the liver&#8217;s ability to regenerate and lead to liver damage. Alcoholic\u00a0liver\u00a0disease is usually divided into 3 stages: alcoholic fatty liver disease, alcoholic hepatitis and cirrhosis, depending on the degree of fat accumulation, inflammation, and\u00a0fibrosis.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"2\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How many people have alcohol-related liver disease?<\/span>\n                        <span id=\"icon-2\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-2\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>The prevalence of alcohol-related related liver disease varies around the world, as the amount of alcohol consumed generally depends on cultural acceptance. In the United States, an estimated 3-5% of people suffer from some degree of alcoholic\u00a0liver\u00a0disease.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"3\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How is alcohol-related liver disease treated?<\/span>\n                        <span id=\"icon-3\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-3\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Currently, there is no specific treatment for alcoholic\u00a0liver\u00a0disease and the most successful intervention is the cessation of alcohol consumption. Abstaining from alcohol reduces the risk of further damage to the liver to a level where there is a chance that the liver will recover. With lifestyle changes, nonalcoholic steatohepatitis is reversible. However, in alcoholic steatohepatitis, liver transplantation may be required in severe cases, such as decompensated cirrhotics.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"4\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How is alcohol-related liver disease diagnosed?<\/span>\n                        <span id=\"icon-4\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-4\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Diagnosis of alcohol-related related liver disease relies on blood tests to assess liver function and alcohol consumption questionnaires. If blood tests indicate decreased liver function and advanced liver damage, further testing including imaging and liver biopsies may be required to determine the pathology of steatohepatitis.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                    <\/ul>\n    \n    <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col xl:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Get in 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