{"id":695,"date":"2025-01-21T16:28:59","date_gmt":"2025-01-21T16:28:59","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker-solutions&#038;p=695"},"modified":"2025-06-04T13:00:52","modified_gmt":"2025-06-04T13:00:52","slug":"scleroderma-systemic-sclerosis","status":"publish","type":"biomarker-solution","link":"https:\/\/www.nordicbioscience.com\/biomarker-solution\/dermatology\/scleroderma-systemic-sclerosis\/","title":{"rendered":"Scleroderma (Systemic Sclerosis)"},"content":{"rendered":"<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Biomarkers for investigating scleroderma (systemic sclerosis)<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>Autoimmune diseases, such as scleroderma\u2014systemic sclerosis (SSc)\u2014affect several tissues, leading to fibrotic tissue buildup of the skin and internal organs. Fibrosis is caused by an increased synthesis of extracellular matrix (ECM), which plays a key role in SSc pathogenesis.<\/p>\n<div>\n<h3 class=\"mb-1 small-title group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">Did you know?<\/h3>\n<\/div>\n<div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n<div class=\"blog-item\">\n<div class=\"container-fluid container-master\">\n<div class=\"block block-mb-negative block-imgs-fg block-grid block-theme-blue block-v-sm text-left fancyfake-item\">\n<div class=\"row mx-0\">\n<div class=\"col-12 col-lg-6 px-0\">\n<div class=\"block-content\">\n<p><a href=\"https:\/\/www.nordicbioscience.com\/blog\/extracellular-matric-animation\/\">Extracellular matrix-specific biomarkers<\/a>\u00a0that help us quantify and monitor fibrosis of the skin internal organs are key when we want to understand the disease mechanisms and prediction of scleroderma\/SSc progression. <a href=\"https:\/\/www.nordicbioscience.com\/blog\/biomarkers-in-drug-development\/\">Utilizing biomarkers<\/a> can help address several aspects of unmet needs in SSc. A well-designed biomarker program enables precise diagnosis, prediction of clinical course and organ involvement, evaluation of therapeutic responsiveness, and identification of novel therapeutic targets.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n                <\/div>\n                                    <div class=\"mt-8 mb-4 xl:mb-8 links\">\n                        <h3 class=\"mb-2 text-blue group-[.dark]:text-fontlight text-body-sm\">Publications<\/h3>\n                        <ul class=\"flex flex-wrap gap-2\">\n                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=%22systemic%20sclerosis%22\" target=\"_blank\">SSc<\/a>\n                                    <\/li>\n                                                                                    <\/ul>\n                    <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/rheumatology\/biomarker-panel\/systemic-sclerosis\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"_blank\">\n            Explore our biomarkers for SSc            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/shutterstock-511367386-646cdc1f666f3-scaled.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"one-column-block bg-grey py-10\">\n<div class=\"inner xl:p-10 xl:pt-20 xl:pb-20 lg:p-8 p-5 max-w-[1440px] mx-auto\">\n\n        <div class=\"max-w-[900px] mx-auto wysiwyg\">\n            <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Biomarkers associated with early diffuse SSc<\/h2>\n            <p>The distribution of skin involvement is a key factor in classifying SSc patients into limited or diffuse cutaneous subtypes. Diffuse cutaneous SSc is characterized by widespread skin involvement, affecting the torso, face, and both the upper and lower limbs. Compared to limited cutaneous SSc, diffuse SSc is more aggressive, with greater organ involvement and higher mortality rates. In a study published in <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0207324\">PLoS One, in 2018 <\/a>, biomarkers of type III and VI collagen formation PRO-C3 and PRO-C6, as well as type III and VI collagen degradation C3M and C6M, were generally elevated in both early (&lt;2Y) and late stages (&gt;10Y) of diffuse SSc compared to asymptomatic controls (Figure 1). Additionally, early diffuse SSc patients tend to present upregulated ECM biomarker levels compared to late diffuse SSc patients. This study suggests that ECM biomarkers are valuable tools both for investigating disease pathogenesis and serving as diagnostic tools.<\/p>\n<p><!-- wp:image {\"id\":6622,\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/ecm-formation-webp.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6622\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/ecm-formation-webp.webp\" alt=\"\" width=\"1014\" height=\"531\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/ecm-formation-webp.webp 1014w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/ecm-formation-webp-300x157.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/ecm-formation-webp-768x402.webp 768w\" sizes=\"auto, (max-width: 1014px) 100vw, 1014px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Figure 1. <\/strong>Type III and VI collagen biomarker levels of fibrosis and fibrolysis are higher in early diffuse patients compared to asymptomatic controls.<\/em><\/figcaption><\/figure>\n<p><!-- \/wp:image --><\/p>\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n<section class=\"call-to-action\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col\">\n        <article style=\"background-image: url(https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/04\/lila-2-webp-1024x682.webp)\" class=\"bg-cover shadow-main flex overflow-clip flex-col justify-between px-5 py-10 rounded-md bg-gray-600 xl:p-40 text-column xl:rounded-xl after:content-[''] after:block after:inset-0 relative after:absolute after:bg-gradient-to-b from-black\/0 to-black\">\n            <div class=\"max-w-[900px] mx-auto relative z-10\">\n                <div class=\"text-center text-balance\">\n                     \n                    <\/div>\n                    <div class=\"mb-8 text-center !text-fontlight\/90 body-text text-balance\">\n                                            <\/div>\n                    \n                    \n                    <div class=\"flex flex-col items-center w-full gap-4 md:gap-6 xl:mt-8 xl:flex-row xl:justify-center group light-button\">\n                                                                                    <div class=\"w-full text-center md:w-auto\">\n\n                                            <a href=\"mailto:bd@nordicbioscience.com?subject=General%20Inquiry\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Interested to learn more? Reach out!            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                    <\/div>\n                                                                                            <\/div>\n                                                    <\/div>\n                    <\/article>\n                <\/div>\n            <\/section>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2 class=\"block-fc\">Nordic Bioscience can quantify the different layers of the skin<\/h2>\n<p>The skin is the largest organ of the human body, and consists of three different layers; epidermis, dermis and subcutis. These three layers have distinct tissue architectures and functions.<\/p>\n<p>Skin functions are dependent on a complex composition of extracellular matrix (ECM) proteins. The ECM of the skin can be divided into the epidermal ECM, epidermal basement membrane and the papillary\/reticular ECM. The major ECM components of the skin are collagens, which are located in the different tissue compartments to maintain tissue architecture.<\/p>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/technology\/protein-fingerprint\" target=\"_blank\" rel=\"noopener noreferrer\">The Nordic ProteinFingerPrint Technology\u2122<\/a>\u00a0allows for the quantification of the different layers of the skin, and also the quantification of immune cell activity involved in different pathologies (Mast Cells, Neutrophils, and macrophages).<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <p><!-- wp:image {\"id\":5931,\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure><\/figure>\n<p>&nbsp;<\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/skin-layers.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-5931\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/skin-layers.webp\" alt=\"\" width=\"2048\" height=\"895\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/skin-layers.webp 2048w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/skin-layers-300x131.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/skin-layers-1024x448.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/skin-layers-768x336.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/skin-layers-1536x671.webp 1536w\" sizes=\"auto, (max-width: 2048px) 100vw, 2048px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>The different layers of the skin<\/em><\/figcaption><\/figure>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n<section class=\"one-column-block bg-grey py-10\">\n<div class=\"inner xl:p-10 xl:pt-20 xl:pb-20 lg:p-8 p-5 max-w-[1440px] mx-auto\">\n\n        <div class=\"max-w-[900px] mx-auto wysiwyg\">\n            <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Pharmacodynamics in SSC<\/h2>\n            <p>Understanding the relationship between SSc and circulating biomarkers is key for drug development, as it facilitates patient stratification and the assessment of therapeutic responses, e.g. pharmacodynamic effect of ECM biomarkers in tocilizumab treatment.<\/p>\n<p>Efforts are underway to identify circulating molecular biomarkers in SSc to predict disease progression and assess drug mechanisms. A recent study from the fouSSced trial, published in <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37479123\/\">Clinical Immunology<\/a>, showed that 48 weeks of tocilizumab treatment led to treatment-related reductions in C3M and C4M levels (Figure 3 A and B). This occurs as the inhibition of IL-6 leads to reduced MMP-9 activity, which in turn reduces the cleavage of type III and IV collagen.<\/p>\n<p>The TFG-\u03b2 pathway biomarker PRO-C3 correlated with mRSS (\u03c1\u00a0=\u00a00.3). However, treatment with tocilizumab did not impact the fibrosis component of the disease, hence the levels of PRO-C3, which reflect fibrosis, were not modulated. These findings suggest that our biomarkers can be used to evaluate the effect of treatment in the fibrolysis and fibrosis component of the disease.<\/p>\n<p><!-- wp:image {\"id\":6634,\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><!-- wp:image {\"id\":6634,\"sizeSlug\":\"full\",\"linkDestination\":\"none\",\"align\":\"center\"} --><\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1008\" height=\"524\" class=\"wp-image-6634 aligncenter\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/studyinfo-webp.webp\" alt=\"\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/studyinfo-webp.webp 1008w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/studyinfo-webp-300x156.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/studyinfo-webp-768x399.webp 768w\" sizes=\"auto, (max-width: 1008px) 100vw, 1008px\" \/><figcaption class=\"wp-element-caption\"><em><strong>Figure 3.<\/strong> Degradation ECM biomarkers show a pharmacodynamic effect with Tocilizumab (anti IL-6 receptor).<\/em><\/figcaption><\/figure>\n<p><!-- \/wp:image --><\/figure>\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Biomarkers associated with SSc disease progression<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>A balanced ECM is necessary to preserve organ integrity and tissue homeostasis. Quantification of ECM remodelling offers valuable insight into the structural and functional changes associated with disease progression. A study published in<a href=\"https:\/\/www.thelancet.com\/journals\/lanrhe\/article\/PIIS2665-9913(20)30385-4\/fulltext\"><strong> The Lancet, in 2021,<\/strong><\/a> showed a dysregulation of neo-epitopes of type III and IV collagens in patients with systemic sclerosis with progressive fibrosis compared to non-progressive patients.<\/p>\n<p>The fibrosis biomarkers PRO-C3 and the type IV collagen turnover PRO-C4 were associated with disease progression (10% decline in FVC%, or increased mRSS &gt;25% during a one-year clinical follow-up). PRO-C3 and PRO-C4, together with tissue type III and IV degradation biomarkers C3M and C4M, were upregulated in progressive disease compared to stable disease (Figure 2).<\/p>\n<p>These findings are explained by feedback loops in extracellular matrix remodelling, in which an increase in collagen synthesis leads to an increase in ECM degradation processes and vice versa. This study suggests that ECM biomarkers are valuable tools for identifying patients in risk of disease progression.<\/p>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/rheumatology\/biomarker-panel\/systemic-sclerosis\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Order biomarkers for SSc            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/ecm20-webp.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"h-the-nordic-proteinfingerprint-technology-in-rheumatic-disorders\">The Nordic ProteinFingerPrint Technology\u2122 in rheumatic disorders<\/h2>\n\n\n\n<p class=\"has-text-align-center\">Unsure about how our technology can benefit your clinical trial in rheumatic disorder? Watch this short video and get an understanding of the benefit you gain from our biomarkers .<\/p>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--40)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Arthritis and Joint Inflammation Animation | Rheumatology Biomarkers\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/_zpAS2YYjJw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n<\/div><\/div>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--70)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"accordion-block\">\n    <div class=\"inner xl:p-10 lg:p-8 lg:pb-0 xl:pb-0 p-5 pb-0 max-w-[1440px] mx-auto\">\n        <div>\n                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg text-navy\">About systemic sclerosis (SSc)<\/h2>\n         \n        <\/div>\n            <ul class=\"accordion\">\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"1\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What is systemic sclerosis?<\/span>\n                        <span id=\"icon-1\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-1\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Systemic sclerosis (SSc) is a chronic rheumatic disease with one of the highest mortalities within\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/rheumatology\/\">rheumatology<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>It is an autoimmune, fibro-inflammatory skin disease characterized by a distinctive triad of microvascular damage (vasculopathy), immune activation with autoimmunity, and generalized fibrosis of multiple organs, including the skin and lungs.<\/p>\n<p>&nbsp;<\/p>\n<p>The great heterogeneity of disease cause and presentation creates considerable challenges in developing treatment and treating patients.<\/p>\n<p>&nbsp;<\/p>\n<p>The prevalence of SSc varies considerably around the world. Northern Europe and parts of Asia have a prevalence of &gt;150 per million, whereas southern Europe, North America, and Australia have a higher prevalence of up to 443 per million.<\/p>\n<p>&nbsp;<\/p>\n<p>As with other autoimmune diseases, women are about six times more likely to get SSc than men.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"2\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How is systemic sclerosis assessed?<\/span>\n                        <span id=\"icon-2\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-2\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Skin fibrosis is assessed by the modified Rodnan Skin Score (mRSS) and the presence of vascular damage, including Raynaud\u2019s Phenomenon, is included in the diagnostic assessment.<\/p>\n<p>&nbsp;<\/p>\n<p>Furthermore, the presence of auto-antibodies and pulmonary involvement (either presented as interstitial lung disease or pulmonary arterial hypertension) is included in the diagnosis.<\/p>\n<p>&nbsp;<\/p>\n<p>There is no cure or disease-modifying drug for SSc, but symptoms and inflammation can be treated using NSAIDs, steroids, or biologics.<\/p>\n<p>&nbsp;<\/p>\n<p>The type of treatment depends on the symptoms and organs involved. Several novel drugs are in development targeting either the inflammatory and\/or the fibrotic axis.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"3\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What characterizes systemic sclerosis?<\/span>\n                        <span id=\"icon-3\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-3\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>Systemic Sclerosis is characterized by microvascular damage (vasculopathy), immune activation with autoimmunity, and generalized fibrosis of multiple organs, including the skin and lungs.<\/p>\n<p>&nbsp;<\/p>\n<p>The different organs that may be affected by SSc have tissues consisting mainly of collagens.<\/p>\n<p>&nbsp;<\/p>\n<p>The collagens are remodeled as part of normal homeostasis of the organ\u2013 that is, collagens are broken down and rebuilt as part of normal repair and maintenance of the tissue.<\/p>\n<p>&nbsp;<\/p>\n<p>In SSc, the balance of tissue remodeling, i.e. formation and degradation of ECM proteins, is interrupted resulting in fibrosis of the organs.<\/p>\n<p>&nbsp;<\/p>\n<p>Similarly, vascular remodeling leads to increased or disrupted vascularization, which may be detected by increased turnover of the ECM proteins of the vasculature.<\/p>\n<p>&nbsp;<\/p>\n<p>Nordic Bioscience&#8217;s\u00a0biomarkers can directly quantify this fibrosis and microvascular damage in a serum sample.<!-- wp:heading {\"textAlign\":\"center\"} --><\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"4\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">Can ECM biomarkers predict systemic sclerosis disease progression?<\/span>\n                        <span id=\"icon-4\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-4\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"1086\" data-end=\"1423\">Yes, studies have shown that biomarkers such as PRO-C3 and PRO-C4 are associated with clinical deterioration, such as FVC decline or skin score increase. These markers provide a molecular readout of fibrotic activity and can identify patients with progressive disease.<\/p>\n<article class=\"text-token-text-primary w-full\" dir=\"auto\" data-testid=\"conversation-turn-114\" data-scroll-anchor=\"true\">\n<div class=\"text-base my-auto mx-auto py-5 [--thread-content-margin:--spacing(4)] @[37rem]:[--thread-content-margin:--spacing(6)] @[72rem]:[--thread-content-margin:--spacing(16)] px-(--thread-content-margin)\">\n<div class=\"[--thread-content-max-width:32rem] @[34rem]:[--thread-content-max-width:40rem] @[64rem]:[--thread-content-max-width:48rem] mx-auto flex max-w-(--thread-content-max-width) flex-1 text-base gap-4 md:gap-5 lg:gap-6 group\/turn-messages focus-visible:outline-hidden\" tabindex=\"-1\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"relative flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"17c4bd67-e7b5-46f7-9ebb-c4eae7e71af2\" data-message-model-slug=\"gpt-4o\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\n<div class=\"markdown prose dark:prose-invert w-full break-words dark\">\n<p data-start=\"1425\" data-end=\"1774\" data-is-last-node=\"\" data-is-only-node=\"\">ECM biomarkers respond to treatments like tocilizumab, making them useful for evaluating pharmacodynamic effects. Reductions in degradation markers (e.g., C3M and C4M) indicate therapeutic impact on tissue breakdown processes, helping guide treatment decisions and clinical trial design.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                    <\/ul>\n    \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col xl:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column\">\n            <div class=\"\">\n                <div>\n                   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This site is protected by reCAPTCHA and the Google\n    <a href=\"https:\/\/policies.google.com\/privacy\">Privacy Policy<\/a> and\n    <a href=\"https:\/\/policies.google.com\/terms\">Terms of Service<\/a> apply.<\/span><\/label><\/span><\/span><\/span>\n\n\n\n<input class=\"wpcf7-form-control wpcf7-submit has-spinner\" type=\"submit\" value=\"Submit request\" \/><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n                <\/div>\n            <\/div>\n                    <\/article>\n        <figure class=\"flex-1 hidden h-auto rounded-md xl:block -order-1 xl:order-none xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover h-full\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2024\/12\/8f7ca89c8e79f07c1ca8c413139cd495-scaled.jpeg\" alt=\"a person wearing a blue lab coat, gloves, and safety glasses, working in a laboratory setting. They are using a pipette to transfer liquid into small bottles, surrounded by lab equipment and vials.\">\n        <\/figure>   \n   <\/div>\n<\/section>\n\n\n<section class=\"call-to-action\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col\">\n        <article style=\"background-image: url()\" class=\"bg-cover shadow-main flex overflow-clip flex-col justify-between px-5 py-10 rounded-md bg-gray-600 xl:p-40 text-column xl:rounded-xl after:content-[''] after:block after:inset-0 relative after:absolute after:bg-gradient-to-b from-black\/0 to-black\">\n            <div class=\"max-w-[900px] mx-auto relative z-10\">\n                <div class=\"text-center text-balance\">\n                     \n                    <\/div>\n                    <div class=\"mb-8 text-center !text-fontlight\/90 body-text text-balance\">\n                        <p><em>Nordic Bioscience&#8217;s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.<\/em><\/p>\n                    <\/div>\n                    \n                                            <\/div>\n                    <\/article>\n                <\/div>\n            <\/section>\n\n\n\n<section id=\"news-section\" class=\"news-events\">\n    <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex flex-col xl:flex-row gap-4 xl:gap-20 xl:\">\n       \n        <!-- NEWS COLUMN -->\n        <article class=\"flex-1 news-column\">\n            <h2 class=\"mb-8 font-bold text-d-title-md text-navy\">News<\/h2>\n                                                <div class=\"pb-4 mb-4 border-b border-gray-200 border-solid news-card\">\n                        <a href=\"https:\/\/www.nordicbioscience.com\/news\/autumn-conference-season-q3-q4\/\">\n                       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Watch this short video and get an understanding of the benefit you gain from our biomarkers .<\/p>\n","protected":false},"featured_media":0,"parent":4879,"menu_order":0,"template":"","meta":{"_acf_changed":true,"inline_featured_image":false},"class_list":["post-695","biomarker-solution","type-biomarker-solution","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker-solution\/695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker-solution"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/biomarker-solution"}],"up":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker-solution\/4879"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}