{"id":687,"date":"2025-01-21T15:57:28","date_gmt":"2025-01-21T15:57:28","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker-solutions&#038;p=687"},"modified":"2025-06-06T08:55:45","modified_gmt":"2025-06-06T08:55:45","slug":"hidradenitis-suppurutiva","status":"publish","type":"biomarker-solution","link":"https:\/\/www.nordicbioscience.com\/biomarker-solution\/dermatology\/hidradenitis-suppurutiva\/","title":{"rendered":"Hidradenitis Suppurutiva"},"content":{"rendered":"<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Biomarkers for evaluating hidradenitis suppurativa (HS)<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>Systemic skin diseases with local manifestations, such as Hidradenitis Suppurativa, are characterized by excessive tissue remodeling and immune cell activity. This manifests in painful nodules, abscesses, and draining malodorous tunnels, affecting the patient\u2019s quality of life.<\/p>\n<p>Tissue-specific biomarkers, quantifying and monitoring epidermal damage, dermal damage and immune cell activity, are\u00a0key advantages\u00a0when understanding the disease mechanisms and complexity in hidradenitis suppurativa, and lead to targeted successful treatments.<\/p>\n<div>\n<h3 class=\"mb-1 small-title group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">Did you know?<\/h3>\n<\/div>\n<div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n<p>Hidradenitis suppurutiva has several aspects of unment needs. These needs can addressed by utilizing biomarkers to reduce diagnostic delay, closer monitoring of disease activity, define disease heterogeneity, refine drug repurposing and identify novel therapeutic targets.<\/p>\n<p>Currently a trial-and-error approach is used when treating patients with hidradenitis suppurativa. This could be improved by predictive biomarkers allowing the selection of therapy with a greater reliability of response.<\/p>\n<\/div>\n                <\/div>\n                                    <div class=\"mt-8 mb-4 xl:mb-8 links\">\n                        <h3 class=\"mb-2 text-blue group-[.dark]:text-fontlight text-body-sm\">Publications<\/h3>\n                        <ul class=\"flex flex-wrap gap-2\">\n                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/publication\/?search=%22hidradenitis%22\" target=\"_blank\">Hidradenitis suppurutiva<\/a>\n                                    <\/li>\n                                                                                    <\/ul>\n                    <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/hidradenitis-suppurutiva-e1738324258963.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Nordic ProteinFingerPrint Technology\u2122 biomarkers in hidradenitis suppurativa<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>Our\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/dermatology\/\">dermatology biomarker panels\u00a0<\/a>offer extracellular matrix-based-based biomarkers, which are fundamentally more different and more specific compared to what\u2019s offered by\u00a0omics providers.<\/p>\n<p>Our <a href=\"https:\/\/www.nordicbioscience.com\/technology\/nordic-proteinfingerprint-technology\/\">Nordic ProteinFingerPrint Technology\u2122<\/a>\u00a0provides valuable insights into tissue formation, degradation, and resolution, that offer a deeper understanding of pathological processes related to skin diseases. At the same time, proteomics providers\u2019 wide-range arrays may not offer the same level of specificity.<\/p>\n<p>Tissue remodeling\u00a0and immune cell activity are key features of hidradenitis suppurativa. Quantifying disease activity and remodeling in hidradenitis suppurativa can provide a unique insight into structural and functional changes in the disease pathogenesis. In addition, one of the key features of the biomarkers is the ability to monitor the disease activity, as shown by with association to the Satorious and IHS4 scores.<\/p>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/dermatology\/biomarker-panel\/hidradenitis-suppurutiva\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Browse hidradenitis suppurutiva biomarkers            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/05\/biomarker-antibody-nordic-bioscience.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Precision medicine and hidradenitis suppurativa<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>Our dermatology biomarkers enable precision medicine by providing information about ongoing pathological processes, such as damage and repair, within the ECM. This can guide targeted treatments and therapies, enhancing patient outcomes and personalized medicine approaches. At the same time, our markers, supported by our long history of experience and expertise, expedite drug development by specifically identifying target populations and reducing costs, over proteomic providers\u2019 hopes to hit the right target by chance.<\/p>\n<p>In addition,\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/laboratory-services\/\" data-type=\"page\" data-id=\"1976\">our technology is robust<\/a>\u00a0and meets CLSI validation guidelines. Additionally, our derma markers can be adapted to the Roche automated platforms, making the biomarkers easily accessible worldwide. This scalability and reliability are crucial for developing dependable clinical research tools.<\/p>\n<p>Since genetic mutations of collagens lead to skin diseases, our biomarkers are genetically linked to skin diseases\u2014diseases that are visible on the skin by the naked eye. Our derma biomarkers not only clearly indicate a presence of a disease in a patient, but also indicate a local manifestation of an underlying systemic cause.<\/p>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/dermatology\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Explore our dermatology biomarkers            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/05\/nordic_bio32047.jpg\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"one-column-block bg-grey py-10\">\n<div class=\"inner xl:p-10 xl:pt-20 xl:pb-20 lg:p-8 p-5 max-w-[1440px] mx-auto\">\n\n        <div class=\"max-w-[900px] mx-auto wysiwyg\">\n            <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Biomarkers associated with disease severity and activity in hidradenitis suppurativa<\/h2>\n            <p>A balanced <a href=\"https:\/\/www.nordicbioscience.com\/blog\/extracellular-matric-animation\/\">extracellular matrix (ECM)<\/a> is necessary to preserve skin integrity and tissue homeostasis. Several ECM components of the dermis, epidermis, and epidermal basement membrane, reflecting the individual skin compartments are remodeled during hidradenitis suppurativa progression. Biomarkers related to disease severity and activity in hidradenitis suppurativa\u00a0are crucial for use in clinical trials, but also to advance the knowledge of the biological complexity behind hidradenitis suppurativa.<\/p>\n<p>The biomarkers utility in disease severity (Hurley staging) and disease activity (Satorious Score, HSS) are depicted by\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/c1m\/\" data-type=\"biomarker\" data-id=\"1217\">C1M<\/a>\u00a0(Dermis degradation; MMP-degraded type I collagen) and\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/cpa9-hne\/\" data-type=\"biomarker\" data-id=\"1023\">CPa9-HNE<\/a> (Neutrophil activity; S100A9 degraded by human neutrophil elastase), in Figure 1. Both biomarkers are associated with disease severity and activity.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/disease.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6556\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/disease.webp\" alt=\"\" width=\"1024\" height=\"264\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/disease.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/disease-300x77.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/disease-768x198.webp 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><em><strong>Figure 1.\u00a0<\/strong>The C1M and CPa9-HNE biomarkers are associated with disease severity and activity<\/em><\/p>\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2>Nordic Bioscience can quantify the different layers of the skin<\/h2>\n<p>The skin is the largest organ of the human body, and consists of three different layers; epidermis, dermis and subcutis. These three layers have distinct tissue architectures and functions.<\/p>\n<p>Skin functions are dependent on a complex composition of extracellular matrix (ECM) proteins. The ECM of the skin can be divided into the epidermal ECM, epidermal basement membrane and the papillary\/reticular ECM. The major ECM components of the skin are collagens, which are located in the different tissue compartments to maintain tissue architecture.<\/p>\n<p>The\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/technology\/nordic-proteinfingerprint-technology\/\" data-type=\"page\" data-id=\"2167\">Nordic ProteinFingerPrint Technology\u2122<\/a> allows for the quantification of the different layers of the skin, and also the quantification of immune cell activity involved in different pathologies (mast cells, <a href=\"https:\/\/www.nordicbioscience.com\/technology\/cpa9-hne-nordiccpa9-hne-the-serum-calprotectin\/\">neutrophils<\/a>, and macrophages).<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure><\/figure>\n<p>&nbsp;<\/p>\n<figure><\/figure>\n<figure><\/figure>\n<figure class=\"wp-block-image aligncenter size-full\">\n<a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/quantify-different-layers-of-the-skin-scaled.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-681\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/quantify-different-layers-of-the-skin-scaled.webp\" alt=\"\" width=\"2560\" height=\"1119\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/quantify-different-layers-of-the-skin-scaled.webp 2560w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/quantify-different-layers-of-the-skin-300x131.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/quantify-different-layers-of-the-skin-1024x447.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/quantify-different-layers-of-the-skin-768x336.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/quantify-different-layers-of-the-skin-1536x671.webp 1536w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/quantify-different-layers-of-the-skin-2048x895.webp 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>The different layers of the skin<\/em><\/figcaption><\/figure>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n<section class=\"accordion-block\">\n    <div class=\"inner xl:p-10 lg:p-8 lg:pb-0 xl:pb-0 p-5 pb-0 max-w-[1440px] mx-auto\">\n        <div>\n         \n        <\/div>\n            <ul class=\"accordion\">\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"1\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">About hidradenitis suppurutiva (HS)<\/span>\n                        <span id=\"icon-1\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-1\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p><span class=\"NormalTextRun SCXW98731086 BCX8\">Hidradenitis suppurativa is a chronic debilitating systemic skin disease, resulting in painful inflammatio<\/span><span class=\"NormalTextRun SCXW98731086 BCX8\">n and follicles in the armpit, groin, and genitalia regions. <\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"NormalTextRun SCXW98731086 BCX8\">It affects 4% of the population, and the disease onset occurs in the second decade of a patient\u2019s life with 2:3 of the patients being women.<\/span><\/p>\n<p>&nbsp;<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"2\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How is hidradenitis suppurutiva diagnosed and treated?<\/span>\n                        <span id=\"icon-2\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-2\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p><span class=\"NormalTextRun SCXW98731086 BCX8\">The patient is diagnosed by a physical examination an<\/span><span class=\"NormalTextRun SCXW98731086 BCX8\">d can be treated with topical, oral or intravenous antibiotic treatments.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"NormalTextRun SCXW98731086 BCX8\"> The treatments provide temporary relief, and some patients undergo surgical treatment to reduce the pain.<\/span><\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"3\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What role do Nordic ProteinFingerPrint\u2122 biomarkers play in hidradenitis suppurutiva?<\/span>\n                        <span id=\"icon-3\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-3\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p><span class=\"NormalTextRun SCXW98731086 BCX8\">Recently adalimumab (TNF-a inhibitor) has been approved for moderate to se<\/span><span class=\"NormalTextRun SCXW98731086 BCX8\">vere hidradenitis suppurativa, while no biological treatments are available for patients with mild disease.<\/span><\/p>\n<p><span class=\"NormalTextRun SCXW98731086 BCX8\"><span class=\"TextRun SCXW183756272 BCX8\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW183756272 BCX8\">Hidradenitis Suppurativa is charac<\/span><span class=\"NormalTextRun SCXW183756272 BCX8\">terized as a dermatological disease where the tissue architecture is being remodeled. <\/span><\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"NormalTextRun SCXW98731086 BCX8\"><span class=\"TextRun SCXW183756272 BCX8\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW183756272 BCX8\">The main component of the skin\u00a0are collagens, which are remodeled as a part of the normal homeostasis of the skin. <\/span><\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"NormalTextRun SCXW98731086 BCX8\"><span class=\"TextRun SCXW183756272 BCX8\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW183756272 BCX8\">In hidradenitis suppurativa, there is an imbalance of tissue<\/span><span class=\"NormalTextRun SCXW183756272 BCX8\">\u00a0build-up and tissue breakdown, resulting in a net degradation of the tissue.\u00a0<\/span><\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"NormalTextRun SCXW98731086 BCX8\"><span class=\"TextRun SCXW183756272 BCX8\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW183756272 BCX8\">Nordic Bioscience\u2019s<\/span><\/span><span class=\"TextRun 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