{"id":6595,"date":"2025-05-16T07:53:43","date_gmt":"2025-05-16T07:53:43","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=news&p=6595"},"modified":"2025-09-30T07:37:03","modified_gmt":"2025-09-30T07:37:03","slug":"press-release-nordic-bioscience-launches-novel-endotrophin-assay","status":"publish","type":"news","link":"https:\/\/www.nordicbioscience.com\/news\/press-release-nordic-bioscience-launches-novel-endotrophin-assay\/","title":{"rendered":"PRESS RELEASE: Nordic Bioscience Launches Novel Endotrophin Assay"},"content":{"rendered":"\n
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The nordicEndotrophin\u2122 high-precision sandwich assay is available on fully automated, high-accuracy, high-throughput platforms<\/h2>\n<\/blockquote>\n\n\n\n

Herlev, May 16, 2025 <\/strong>\u2013 Nordic Bioscience introduces nordicEndotrophin\u2122<\/a>, a fully automated high-precision assay that selectively quantifies the intact 77-amino-acid Endotrophin signaling hormone\u2014qualified in the CAP\/CLIA certified Nordic Bioscience laboratory. When integrated with the company\u2019s existing product line, the biomarker assay demonstrated prognostic utility in fibrosis and cancer studies1<\/sup>.<\/p>\n\n\n\n

NordicEndotrophin\u2122 joins nordicPRO-C6\u2122<\/a> and nordicPRO-C3\u2122<\/a> (in-house versions of the FDA-supported PRO-C6 and CE approved PRO-C3 assays) to deliver a one-stop solution for assessing the fibro-inflammatory axis in chronic diseases, including cardiovascular, metabolic, renal and more. Following PRO-C3\u2019s recent deployment on Roche IVD platforms, the new Endotrophin assay strengthens risk stratification and pharmacodynamic monitoring.<\/p>\n\n\n\n

Endotrophin was first identified in 2012 as a collagen-derived hormone released from type VI collagen. Type VI collagen is a contributor to fibroblast activation and driver of fibrosis across organs\u2014inflammatory processes that underlie roughly 40 percent of deaths in Western countries2<\/sup>. Obesity exacerbates this by activating fibroblasts in the liver, kidney and heart. Across a range of chronic diseases, patients with a two-fold increase of circulating Endotrophin levels increased risk of mortality by 100%1,2<\/sup>. Quantifying Endotrophin enables researchers to connect wound healing and fibrotic progression to patient outcomes, supporting precision-medicine approaches that pharmacodynamically modulate this dangerous hormone.<\/p>\n\n\n\n

Whereas PRO-C6<\/a>, Nordic Bioscience’s first hand-held ELISA assay measuring the formation of the total pool of type VI collagen (a3 chain encompassing 12 Von Willebrand binding domains), a collagen responsible for binding of platelets that cause fibroblast activation and would healing, nordicEndotrophin\u2122 specifically measures the intact 77-amino-acid hormone. This specificity means additional risk stratification and prognostic value that complement PRO-C6\u2019s fibrosis-driven pharmacodynamic insights1<\/sup>.<\/p>\n\n\n\n

\u201cEndotrophin is a significant prognostic biomarker to emerge<\/em>,\u201d said CEO Dr. Morten Karsdal. \u201cEvidenced in a study of HFpEF patients, Endotrophin and PRO-C6 outperformed NT-proBNP in HFpEF for mortality and hospitalization risk3<\/sup>. Together with PRO-C3, quantifying this fibro-inflammatory hormone will refine patient stratification and treatment monitoring across obesity, fibrotic diseases, and autoimmune endotypes.\u201d<\/em><\/p>\n\n\n\n

Offered in Nordic Bioscience\u2019s CAP\/CLIA-certified laboratory in Herlev, Denmark, the nordicEndotrophin\u2122 high-precision sandwich assay is available on fully automated, high-accuracy, high-throughput platforms. To accelerate drug fibro-inflammatory profiling, clients considering nordicEndotrophin\u2122 are invited to co-measure nordicPRO-C3\u2122<\/a> and nordicPRO-C6\u2122<\/a>. Together, these assays facilitate precise risk stratification, dose selection, patient enrichment, proof-of-mechanism and treatment monitoring in anti-fibrotic and oncology trials2<\/sup>.<\/p>\n\n\n\n

About Nordic Bioscience<\/strong><\/p>\n\n\n\n

Nordic Bioscience is a Danish biomarker company headquartered in Herlev, Denmark. We are engaged in biomarker development using our unique neoepitope technology. We combine our expertise in biomarker development with preclinical and clinical research. This enables us to develop biomarkers that provide fast and objective decision-making for compound selection and development in clinical trials as well as provide value for patients in a diagnostic setting. For more information about Nordic Bioscience, visit us at https:\/\/www.nordicbioscience.com<\/p>\n\n\n\n

References:<\/strong><\/p>\n\n\n\n

[1] https:\/\/pubmed.ncbi.nlm.nih.gov\/38871093\/<\/a><\/p>\n\n\n\n

[2] https:\/\/pubmed.ncbi.nlm.nih.gov\/38091968\/<\/a><\/p>\n\n\n\n

[3] https:\/\/pubmed.ncbi.nlm.nih.gov\/37645406\/<\/a><\/p>\n\n\n\n

-END-<\/p>\n\n\n\n

For more information please contact:<\/p>\n\n\n\n

Nordic Bioscience A\/S
Herlev Hovedgade 205
2730 Herlev, Denmark
preferably via email mk(@)nordicbio.com
<\/a>For product related inquires please use https:\/\/www.nordicbioscience.com\/contact<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"

The nordicEndotrophin\u2122 high-precision sandwich assay is available on fully automated, high-accuracy, high-throughput platforms Herlev, May 16, 2025 \u2013 Nordic Bioscience introduces nordicEndotrophin\u2122, a fully automated high-precision assay that selectively quantifies the intact 77-amino-acid Endotrophin signaling hormone\u2014qualified in the CAP\/CLIA certified Nordic Bioscience laboratory. When integrated with the company\u2019s existing product line, the biomarker assay demonstrated prognostic […]<\/p>\n","protected":false},"featured_media":6181,"template":"","meta":{"_acf_changed":true,"inline_featured_image":false},"class_list":["post-6595","news","type-news","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/news\/6595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media\/6181"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=6595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}