{"id":2515,"date":"2025-02-06T10:27:47","date_gmt":"2025-02-06T10:27:47","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker-solutions&#038;p=2515"},"modified":"2025-06-01T14:55:54","modified_gmt":"2025-06-01T14:55:54","slug":"translational-models","status":"publish","type":"biomarker-solution","link":"https:\/\/www.nordicbioscience.com\/biomarker-solution\/translational-models\/","title":{"rendered":"Translational Models"},"content":{"rendered":"<section class=\"hero relative z-[2] lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto\">\n    <div style=\"background-image: linear-gradient(0deg, rgba(0,0,0,1) 0%, rgba(0,0,0,0) 100%), url(https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/shutterstock_1906479334-scaled.webp)\" class=\"shadow-main overlay flex flex-col min-h-[80svh] lg:min-h-[60svh] justify-end py-10 p-5 lg:p-8 xl:p-10 bg-cover rounded-md lg:rounded-lg xl:rounded-xl xl:min-h-[800px]\">\n        <article>\n                                        <h2 class=\"mb-4 font-bold text-white xl-mb-6 text-m-title-lg lg:text-d-title-xl font-poppins\">Translational models for pre-clinical and clinical studies<\/h2>\n                                        <p class=\"mb-8 text-gray-300 xl:mb-10 xl:w-1\/2 font-poppins\">Tissue-based tools drive drug development in both pre-clinical and clinical phases to improve the success rate of drug development. Accordingly, the FDA and EMA have expressed the view that biomarker-based drug development strategies, in combination with translational research, may offer a biology-focused approach that reduces time and cost and increases the overall likelihood of success.<\/p>\n                                                <div class=\"flex flex-wrap gap-6 xl:mt-8 group light-button\">\n                                                                                            <a href=\"mailto:bd@nordicbioscience.com?subject=Translational%20models%20%7C%20Inquiry\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Get in touch with our team            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n    <\/div>\n<\/section>\n\n\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Strategic drug development in translational studies<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p class=\"has-medium-font-size\">A drug development route for success is key but often challenging and full of uncertainties. Strategies that can increase the likelihood of success are vital. The FDA and EMA recognize that biomarker-based drug development strategies, in combination with translation research, could be the solution. This approach offers a biology-focused pathway that not only reduces time and cost but also enhances the overall likelihood of success.<\/p>\n<p>Nordic Bioscience combines innovative translational models with the\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/technology\/nordic-proteinfingerprint-technology\/\">ProteinFingerPrint Technology\u2122<\/a>\u00a0to translate findings effectively. This is facilitated by utilizing the same biomarkers across different clinical stages of development creating a link between the preclinical model and the clinic. This strategically selected development route greatly enhances the efficiency of drug development pipelines.<\/p>\n<p>In essence, the integration of biomarker-based drug development strategies in translational research not only accelerates the progression of therapeutics but also increases the likelihood of success. Through advanced translational models in combination with the <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/\">ProteinFingerPrint\u2122 biomarkers<\/a>, Nordic Bioscience contributes significantly to the optimization of decision-making processes in clinical development, ultimately ensuring better treatments for the patients.<\/p>\n                <\/div>\n                                    <div class=\"mt-8 mb-4 xl:mb-8 links\">\n                        <h3 class=\"mb-2 text-blue group-[.dark]:text-fontlight text-body-sm\">We offer translational biomarker services in various indications<\/h3>\n                        <ul class=\"flex flex-wrap gap-2\">\n                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/gastrointestinal\/translational-models-in-ibd\/\" target=\"_blank\">Inflammatory Bowel Diseases<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/translational-models-in-hepatic-fibrosis\/\" target=\"_blank\">Hepatic Fibrosis<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/respiratory\/translational-models-in-pulmonary-fibrosis\/\" target=\"_blank\">Pulmonary fibrosis<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/rheumatology\/translational-models-in-rheumatology\/\" target=\"_blank\">Rheumatology<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/dermatology\/translational-models-in-dermatology\/\" target=\"_blank\">Skin diseases<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/oncology\/translational-models-in-oncology\/\" target=\"_blank\">Tumor microenvironment<\/a>\n                                    <\/li>\n                                                                                    <\/ul>\n                    <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/shutterstock_171231248-scaled.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"call-to-action\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col\">\n        <article style=\"background-image: url(https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/04\/lila-2-webp-1024x682.webp)\" class=\"bg-cover shadow-main flex overflow-clip flex-col justify-between px-5 py-10 rounded-md bg-gray-600 xl:p-40 text-column xl:rounded-xl after:content-[''] after:block after:inset-0 relative after:absolute after:bg-gradient-to-b from-black\/0 to-black\">\n            <div class=\"max-w-[900px] mx-auto relative z-10\">\n                <div class=\"text-center text-balance\">\n                     \n                    <\/div>\n                    <div class=\"mb-8 text-center !text-fontlight\/90 body-text text-balance\">\n                                            <\/div>\n                    \n                    \n                    <div class=\"flex flex-col items-center w-full gap-4 md:gap-6 xl:mt-8 xl:flex-row xl:justify-center group light-button\">\n                                                                                    <div class=\"w-full text-center md:w-auto\">\n\n                                            <a href=\"mailto:bd@nordicbioscience.com?subject=General%20Inquiry\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Interested to learn more? Reach out!            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                    <\/div>\n                                                                                            <\/div>\n                                                    <\/div>\n                    <\/article>\n                <\/div>\n            <\/section>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2>The translational need in extracellular matrix (ECM) biology<\/h2>\n<p>The need to translate results from basic to clinical research arises from the nature of initial in vitro experiments, which are simplified models of the more complex clinical setting.<\/p>\n<p>For example, primary chondrocytes cultured in single-cell layers with serum have different conditions and are less clinically relevant than chondrocytes scattered in a dense ECM in the articular cartilage of a human joint.<\/p>\n<p>Ex vivo cultures have slightly greater clinical relevance than in vitro experiments due to their more natural ECM environment, but are also more complex and can be more difficult to manipulate experimentally.<\/p>\n<p>Nordic\u2019s models aim to approximate the high throughput of intro studies and the superior translation of in-models by characterizing cellular function in a more transferable 3D environment.<\/p>\n<p>Of course, ex vivo models are still grown under artificial conditions in the laboratory and should be supported by in vivo and clinical research.<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2>Current models and the translational gap<\/h2>\n<p>A wide range of in vitro models are commonly used to test the effects of targets and the stability of profiles, and to test cellular modulation. What many of these models have in common is that they lack the necessary complexity and profiling of downstream effects on tissue, making them less suitable for translational application further down the drug development chain.<\/p>\n<p>From arthritic diseases to various forms of fibrosis and cancer, the need for translational models that can accurately profile the extracellular matrix and support decision-making in clinical development is becoming increasingly important.<\/p>\n<p>Nordic Bioscience&#8217;s translational models use ex vivo, fibroblast, or primary cell cultures cultured in or on appropriate matrices, allowing active profiling of tissue turnover using protein fingerprint biomarkers. For example, an in vitro model won&#8217;t provide the same depth of information as an ex vivo model would:<\/p>\n<ul>\n<li>Quantitative and dynamic measurement of tissue turnover<\/li>\n<li>In vivo replication where cells are maintained in a near-native matrix.<\/li>\n<li>Translational from in vitro to the clinic, allowing the same biomarker to be used at different stages of development.<\/li>\n<\/ul>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2>In vitro\u2014Scar-in-a-Jar (SiaJ)<\/h2>\n<p>The prolonged Scar-in-a-Jar is a novel model that employs macro-molecular crowding to promote extracellular matrix formation, maturation, and deposition\u00a0<em>in vitro<\/em> (Figure 1).<\/p>\n<p>The extracellular matrix plays a crucial role in providing structural support to cells and regulating tissue repair and regeneration by acting as a reservoir for growth factors and cytokines.<\/p>\n<p>Understanding the extracellular matrix dynamics is vital for developing therapeutic strategies. Using macromolecular crowding, the model becomes more 3D-like and increases complexity, making it a suitable translational model.<\/p>\n<p>Afterwards, the\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/\">Nordic ProteinFingerPrint\u2122 biomarkers<\/a>\u00a0can be measured in the supernatants to determine efficacy, subsequently allowing for direct translation to clinical settings.<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-703\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scar-in-a-jar-in-vitro-nordic-bioscience-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><strong><em>Figure 1. <\/em><\/strong><em>Extracellular matrix remodeling\u00a0<\/em>in-vitro\u00a0<em>Scar-in-a-Jar model<\/em><\/figcaption><\/figure>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n<!--\ninitialize dynamic classes\nlg:grid-cols-4\nlg:grid-cols-3\n-->\n<section class=\"four-column\">\n    <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto\">\n        <div class=\"py-5 xl:py-20\">\n            <article class=\"mb-8 xl:text-center xl:mb-10 xl:max-w-[900px] xl:mx-auto\">\n                                    <h2 class=\"mb-1 small-title text-blue\">We offer translational biomarker services in various indications<\/h2>\n                                            <h3 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg text-navy\">Blood-based ECM biomarkers can be utilized in translational models<\/h3>\n                                                    <\/article>\n                            <article class=\"grid gap-4 justify-center grid-cols-2 xl:px-10 lg:grid-cols-4 columns group small \">\n                                            <div class=\"flex gap-4 item\">\n                                                            <figure class=\"aspect-square hidden group-[.large]:w-16 group-[.large]:h-16 group-[.small]:w-10 group-[.small]:h-10 group-[.large]:border-2 group-[.small]:border border-solid rounded-full bg-buttonfill border-turquoise xl:flex justify-center items-center h-fit\">\n                                    <img decoding=\"async\" class=\"group-[.large]:w-8 group-[.large]:h-8 group-[.small]:w-4 group-[.small]:h-4\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2024\/12\/skin.svg\" alt=\"\">\n                                <\/figure>\n                                                        <div>\n                                                                    <h3 class=\"text-m-title-xs text-navy mb-1 lg:group-[.small]:mb-1 lg:mb-2 lg:group-[.small]:text-d-title-2xs lg:group-[.large]:text-d-title-lg font-bold\">Dermatology<\/h3>\n                                                                                                <div class=\"text-body-md xl:text-body-md text-blue wysiwyg-four-column-item\">\n                                    <p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/dermatology\/translational-models-in-dermatology\/\">Translational biomarker solutions in skin diseases.<\/a><\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                                            <div class=\"flex gap-4 item\">\n                                                            <figure class=\"aspect-square hidden group-[.large]:w-16 group-[.large]:h-16 group-[.small]:w-10 group-[.small]:h-10 group-[.large]:border-2 group-[.small]:border border-solid rounded-full bg-buttonfill border-turquoise xl:flex justify-center items-center h-fit\">\n                                    <img decoding=\"async\" class=\"group-[.large]:w-8 group-[.large]:h-8 group-[.small]:w-4 group-[.small]:h-4\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2024\/12\/intestine.svg\" alt=\"\">\n                                <\/figure>\n                                                        <div>\n                                                                    <h3 class=\"text-m-title-xs text-navy mb-1 lg:group-[.small]:mb-1 lg:mb-2 lg:group-[.small]:text-d-title-2xs lg:group-[.large]:text-d-title-lg font-bold\">Inflammatory Bowel Diseases (IBD)<\/h3>\n                                                                                                <div class=\"text-body-md xl:text-body-md text-blue wysiwyg-four-column-item\">\n                                    <p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/gastrointestinal\/translational-models-in-ibd\/\">Translational biomarker solutions in IBD.<\/a><\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                                            <div class=\"flex gap-4 item\">\n                                                            <figure class=\"aspect-square hidden group-[.large]:w-16 group-[.large]:h-16 group-[.small]:w-10 group-[.small]:h-10 group-[.large]:border-2 group-[.small]:border border-solid rounded-full bg-buttonfill border-turquoise xl:flex justify-center items-center h-fit\">\n                                    <img decoding=\"async\" class=\"group-[.large]:w-8 group-[.large]:h-8 group-[.small]:w-4 group-[.small]:h-4\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2024\/12\/liver.svg\" alt=\"\">\n                                <\/figure>\n                                                        <div>\n                                                                    <h3 class=\"text-m-title-xs text-navy mb-1 lg:group-[.small]:mb-1 lg:mb-2 lg:group-[.small]:text-d-title-2xs lg:group-[.large]:text-d-title-lg font-bold\">Hepatology<\/h3>\n                                                                                                <div class=\"text-body-md xl:text-body-md text-blue wysiwyg-four-column-item\">\n                                    <p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/translational-models-in-hepatic-fibrosis\/\">Translational biomarker solutions in hepatic fibrosis.<\/a><\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                                            <div class=\"flex gap-4 item\">\n                                                            <figure class=\"aspect-square hidden group-[.large]:w-16 group-[.large]:h-16 group-[.small]:w-10 group-[.small]:h-10 group-[.large]:border-2 group-[.small]:border border-solid rounded-full bg-buttonfill border-turquoise xl:flex justify-center items-center h-fit\">\n                                    <img decoding=\"async\" class=\"group-[.large]:w-8 group-[.large]:h-8 group-[.small]:w-4 group-[.small]:h-4\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2024\/12\/cancer.svg\" alt=\"\">\n                                <\/figure>\n                                                        <div>\n                                                                    <h3 class=\"text-m-title-xs text-navy mb-1 lg:group-[.small]:mb-1 lg:mb-2 lg:group-[.small]:text-d-title-2xs lg:group-[.large]:text-d-title-lg font-bold\">Oncology<\/h3>\n                                                                                                <div class=\"text-body-md xl:text-body-md text-blue wysiwyg-four-column-item\">\n                                    <p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/oncology\/translational-models-in-oncology\/\">Translational biomarker solutions in the tumor microenvironment.<\/a><\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                                            <div class=\"flex gap-4 item\">\n                                                            <figure class=\"aspect-square hidden group-[.large]:w-16 group-[.large]:h-16 group-[.small]:w-10 group-[.small]:h-10 group-[.large]:border-2 group-[.small]:border border-solid rounded-full bg-buttonfill border-turquoise xl:flex justify-center items-center h-fit\">\n                                    <img decoding=\"async\" class=\"group-[.large]:w-8 group-[.large]:h-8 group-[.small]:w-4 group-[.small]:h-4\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2024\/12\/renal.svg\" alt=\"\">\n                                <\/figure>\n                                                        <div>\n                                                                    <h3 class=\"text-m-title-xs text-navy mb-1 lg:group-[.small]:mb-1 lg:mb-2 lg:group-[.small]:text-d-title-2xs lg:group-[.large]:text-d-title-lg font-bold\">Nephrology<\/h3>\n                                                                                                <div class=\"text-body-md xl:text-body-md text-blue wysiwyg-four-column-item\">\n                                    <p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/kidney-diseases\/translational-models-in-kidney-diseases\/\">Translational biomarker solutions in kidney diseases.<\/a><\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                                            <div class=\"flex gap-4 item\">\n                                                            <figure class=\"aspect-square hidden group-[.large]:w-16 group-[.large]:h-16 group-[.small]:w-10 group-[.small]:h-10 group-[.large]:border-2 group-[.small]:border border-solid rounded-full bg-buttonfill border-turquoise xl:flex justify-center items-center h-fit\">\n                                    <img decoding=\"async\" class=\"group-[.large]:w-8 group-[.large]:h-8 group-[.small]:w-4 group-[.small]:h-4\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2024\/12\/lungs.svg\" alt=\"\">\n                                <\/figure>\n                                                        <div>\n                                                                    <h3 class=\"text-m-title-xs text-navy mb-1 lg:group-[.small]:mb-1 lg:mb-2 lg:group-[.small]:text-d-title-2xs lg:group-[.large]:text-d-title-lg font-bold\">Respiratory<\/h3>\n                                                                                                <div class=\"text-body-md xl:text-body-md text-blue wysiwyg-four-column-item\">\n                                    <p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/respiratory\/translational-models-in-pulmonary-fibrosis\/\">Translational biomarker solutions in pulmonary fibrosis.<\/a><\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                                            <div class=\"flex gap-4 item\">\n                                                            <figure class=\"aspect-square hidden group-[.large]:w-16 group-[.large]:h-16 group-[.small]:w-10 group-[.small]:h-10 group-[.large]:border-2 group-[.small]:border border-solid rounded-full bg-buttonfill border-turquoise xl:flex justify-center items-center h-fit\">\n                                    <img decoding=\"async\" class=\"group-[.large]:w-8 group-[.large]:h-8 group-[.small]:w-4 group-[.small]:h-4\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2024\/12\/joint.svg\" alt=\"\">\n                                <\/figure>\n                                                        <div>\n                                                                    <h3 class=\"text-m-title-xs text-navy mb-1 lg:group-[.small]:mb-1 lg:mb-2 lg:group-[.small]:text-d-title-2xs lg:group-[.large]:text-d-title-lg font-bold\">Rheumatology<\/h3>\n                                                                                                <div class=\"text-body-md xl:text-body-md text-blue wysiwyg-four-column-item\">\n                                    <p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/rheumatology\/translational-models-in-rheumatology\/\">Translational biomarker solutions in rheumatic diseases.<\/a><\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                                    <\/article>\n                    <\/div>\n   <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">The 3DPROFIB model with primary fibroblasts<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>The SiaJ model goes 3D with the new 3DPROFIB in partnership with\u00a0<a href=\"https:\/\/www.ectica-technologies.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">Ectica Technologies<\/a>. This new platform offers the possibility to analyze Nordic Bioscience ECM formation biomarkers from the supernatant of fibroblasts growing in a 3D synthetic and animal-free hydrogel matrix, increasing the translational character of our model and supplementing the biomarker readout with imaging-based readouts.<\/p>\n<p>This platform:<\/p>\n<ul>\n<li class=\"\" data-start=\"388\" data-end=\"535\">\n<p class=\"\" data-start=\"390\" data-end=\"535\">Studies how anti-fibrotic compounds modulate ECM production in a physiologically relevant 3D environment versus traditional 2D plastic cultures<\/p>\n<\/li>\n<li class=\"\" data-start=\"536\" data-end=\"624\">\n<p class=\"\" data-start=\"538\" data-end=\"624\">Supports high-resolution phenotypic characterization via advanced imaging techniques<\/p>\n<\/li>\n<li class=\"\" data-start=\"625\" data-end=\"749\">\n<p class=\"\" data-start=\"627\" data-end=\"749\">Is offered with cardiac, pulmonary, dermal fibroblasts, bone marrow mesenchymal stromal cells and hepatic stellate cells<\/p>\n<\/li>\n<li class=\"\" data-start=\"750\" data-end=\"836\">\n<p class=\"\" data-start=\"752\" data-end=\"836\">Permits co-culture with inflammatory cells, endothelial cells and epithelial cells<\/p>\n<\/li>\n<\/ul>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"mailto:bd@nordicbioscience.com?subject=3DPROFIB%20Inquiry\" class=\"group button outline flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            group\/button\n\n            \" target=\"\">\n            Reach out to us about 3DPROFIB            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/scar-in-a-jar-3dprofib-nordic-bioscience-ectica-technologies.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Ectica\u2019s proprietary 3D hydrogel fibroblast cultures<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>We integrate Ectica Technologies&#8217; proprietary 3D hydrogel fibroblastic cultures into our laboratory services. By coupling this advanced matrix system with our ECM turnover biomarkers, the 3DPROFIB platform further delivers:<\/p>\n<ul data-start=\"1206\" data-end=\"1946\">\n<li class=\"\" data-start=\"1206\" data-end=\"1414\">\n<p class=\"\" data-start=\"1208\" data-end=\"1414\">Exclusive measurement of fibroblast-derived collagen and other matrix fragments, free from background interference, for precise assessment of compound efficacy.<\/p>\n<\/li>\n<li class=\"\" data-start=\"1415\" data-end=\"1605\">\n<p class=\"\" data-start=\"1417\" data-end=\"1605\">Human primary fibroblasts exhibit native morphology and behavior within the synthetic hydrogel, improving predictive value for clinical outcomes.<\/p>\n<\/li>\n<li class=\"\" data-start=\"1606\" data-end=\"1788\">\n<p class=\"\" data-start=\"1608\" data-end=\"1788\">A turnkey service for anti-fibrotic drug discovery, combining high-throughput compound screening with biomarker-driven decision-making.<\/p>\n<\/li>\n<li class=\"\" data-start=\"1789\" data-end=\"1946\">\n<p class=\"\" data-start=\"1791\" data-end=\"1946\">Fully human, animal-free assays that align with 3Rs principles while maintaining rigorous scientific standards.<\/p>\n<\/li>\n<\/ul>\n<p class=\"\" data-start=\"1948\" data-end=\"2160\">Access to 3DPROFIB is available as part of Nordic Bioscience\u2019s pre-clinical and translational drug discovery services. For details on implementing this ECM-driven 3D assay in your fibrosis research, get in touch with our team.<\/p>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"mailto:bd@nordicbioscience.com?subject=3DPROFIB%20Inquiry\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Interested in 3DPROFIB?            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                                                                            <a href=\"https:\/\/www.ectica-technologies.com\/\" class=\"group button subtle flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            py-4 \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            group-[.light-button]:xl:hover:text-turquoise \n            group-[.dark-button]:xl:hover:text-turquoise\n            border-0 \n            group\/subtlebutton\n            \" target=\"_blank\">\n            Ectica&#039;s homepage            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/3dprofib-nordic-bioscience-ectica-technologies.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"accordion-block\">\n    <div class=\"inner xl:p-10 lg:p-8 lg:pb-0 xl:pb-0 p-5 pb-0 max-w-[1440px] mx-auto\">\n        <div>\n                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg text-navy\">About Nordic Bioscience&#8217;s translational models<\/h2>\n         \n        <\/div>\n            <ul class=\"accordion\">\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"1\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What are translational models and why are they important in drug development?<\/span>\n                        <span id=\"icon-1\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-1\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"51\" data-end=\"472\">Translational models bridge the gap between basic research and clinical application by mimicking human disease processes more accurately than traditional in vitro systems. They enable early testing of drug efficacy and safety in a more biologically relevant context, improving decision-making and reducing late-stage clinical trial failures.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"2\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How do Nordic Bioscience&#039;s translational models support fibrosis and ECM research?<\/span>\n                        <span id=\"icon-2\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-2\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"474\" data-end=\"903\">Nordic Bioscience&#8217;s models use 2D and 3D systems\u2014like the Scar-in-a-Jar and 3DPROFIB\u2014to simulate tissue remodeling. These models are paired with ECM biomarkers to quantify fibrogenesis and fibrolysis, enabling translational insight from pre-clinical studies to clinical trials in diseases such as liver fibrosis, pulmonary fibrosis, and cancer.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"3\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What is the Scar-in-a-Jar (SiaJ) model?<\/span>\n                        <span id=\"icon-3\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-3\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"905\" data-end=\"1232\">The SiaJ model is an in vitro system that uses macromolecular crowding to promote ECM production and maturation. It replicates fibrotic processes in a controlled environment, allowing for precise measurement of ECM turnover and drug effects using Nordic ProteinFingerPrint\u2122 biomarkers.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"4\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What advantages does the 3DPROFIB platform offer?<\/span>\n                        <span id=\"icon-4\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-4\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"1234\" data-end=\"1595\">3DPROFIB is a next-generation translational model that uses a 3D, synthetic, animal-free hydrogel matrix to culture primary human fibroblasts. It enhances physiological relevance and allows combined biomarker and imaging-based readouts, supporting high-throughput screening and anti-fibrotic drug development.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"5\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">Which disease areas can benefit from Nordic\u2019s translational biomarker services?<\/span>\n                        <span id=\"icon-5\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-5\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <article class=\"text-token-text-primary w-full\" dir=\"auto\" data-testid=\"conversation-turn-106\" data-scroll-anchor=\"true\">\n<div class=\"text-base my-auto mx-auto py-5 [--thread-content-margin:--spacing(4)] @[37rem]:[--thread-content-margin:--spacing(6)] @[72rem]:[--thread-content-margin:--spacing(16)] px-(--thread-content-margin)\">\n<div class=\"[--thread-content-max-width:32rem] @[34rem]:[--thread-content-max-width:40rem] @[64rem]:[--thread-content-max-width:48rem] mx-auto flex max-w-(--thread-content-max-width) flex-1 text-base gap-4 md:gap-5 lg:gap-6 group\/turn-messages focus-visible:outline-hidden\" tabindex=\"-1\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"relative flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"5530062e-8cc6-41d8-9b80-1b9855f44154\" data-message-model-slug=\"gpt-4o\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\n<div class=\"markdown prose dark:prose-invert w-full break-words dark\">\n<p data-start=\"1597\" data-end=\"1948\" data-is-last-node=\"\" data-is-only-node=\"\">Nordic Bioscience offers translational biomarker solutions across multiple indications, including inflammatory bowel disease, hepatic fibrosis, pulmonary fibrosis, rheumatology, dermatology, nephrology, and oncology\u2014enabling more targeted, data-driven drug development.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                    <\/ul>\n    \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col xl:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Get in touch<\/h2>\n                 \n\n                <\/div>\n                <div class=\"xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <div class=\"mb-10\">\n                        <div class=\"mb-4\">\n                            Are you interested in exploring collaboration possibilities?\u2028Enter your information in the form and a representative will contact you shortly.                        <\/div>\n                                                    <div class=\"flex flex-col gap-1 links\">\n                                                                    <a class=\"flex underline transition ease-out duration-200 hover:text-turquoise hover:after:bg-turquoise after:content-[''] after:[mask-image:url(..\/..\/nordicbioscience\/img\/icons\/hyperlink.svg)] after:w-4 after:h-4 after:bg-navy 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