{"id":2357,"date":"2025-02-01T22:02:13","date_gmt":"2025-02-01T22:02:13","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?page_id=2357"},"modified":"2025-06-06T08:52:41","modified_gmt":"2025-06-06T08:52:41","slug":"from-biomarker-discovery-to-clinical-use","status":"publish","type":"page","link":"https:\/\/www.nordicbioscience.com\/why-biomarkers\/from-biomarker-discovery-to-clinical-use\/","title":{"rendered":"From Biomarker Discovery to Clinical Use"},"content":{"rendered":"<section class=\"title-block\">\n    <div class=\"inner xl:p-10 lg:p-8 lg:pb-0 xl:pb-0 p-5 pb-0 max-w-[1440px] mx-auto\">\n        <div class=\"breadcrumbs\">\n            <ul class=\"flex text-body-sm text-blue\">\n                <li class=\"flex items-center after:mx-[5px] after:content-[''] after:my-auto after:inline-block after:w-1 after:h-1 after:rounded-full after:bg-gray-400 after:aspect-square\">\n                    <a class=\"py-1 opacity-75 xl:hover:opacity-100 truncate max-w-40\" href=\"https:\/\/www.nordicbioscience.com\">Home<\/a>\n                <\/li>\n                <li class=\"flex items-center after:mx-[5px] after:content-[''] after:my-auto after:inline-block after:w-1 after:h-1 after:rounded-full after:bg-gray-400 after:aspect-square\">\n                                <a class=\"opacity-75 xl:hover:opacity-100 truncate max-w-40\" href=\"https:\/\/www.nordicbioscience.com\/why-biomarkers\/\">Why Biomarkers?<\/a>\n                              <\/li>                <li class=\"flex items-center truncate max-w-40\"> \n                    \n                    <p class=\"\"class=\"py-1\">\n                    From Biomarker Discovery to Clinical Use                    <\/p>\n                <\/li>\n            <\/ul>\n        <\/div>\n        <h1 class=\"font-bold text-navy text-m-title-lg xl:text-d-title-lg\">From Biomarker Discovery to Clinical Use<\/h1>\n            <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">From discovery to clinical use<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>Biomarkers have the potential to serve as valuable tools throughout the entire drug development process, but the utility ultimately depends on the refinement, implementation, and qualification of the biomarker. Before reaching a stage where they can provide value, biomarkers must first undergo rigorous testing and validation (figure 1).<\/p>\n<p>Novel biomarker discovery relies on different methodologies, such as imaging and biochemical techniques. The early stages of fluid biomarker discovery usually involve a large screening of analytes in few samples and is successively escalated to few analytes in more samples, as the proof of concept develops.<\/p>\n                <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/05\/nordic_bio32228.jpg\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6924f92ca96ef&quot;}\" data-wp-interactive=\"core\/image\" class=\"aligncenter size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"548\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on-async--click=\"actions.showLightbox\" data-wp-on-async--load=\"callbacks.setButtonStyles\" data-wp-on-async-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/from-biomarker-discovery-to-clinical-use-1024x548.webp\" alt=\"\" class=\"wp-image-2376\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/from-biomarker-discovery-to-clinical-use-1024x548.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/from-biomarker-discovery-to-clinical-use-300x160.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/from-biomarker-discovery-to-clinical-use-768x411.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/from-biomarker-discovery-to-clinical-use-1536x821.webp 1536w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/from-biomarker-discovery-to-clinical-use-2048x1095.webp 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on-async--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\"><em><strong>Figure 1.<\/strong>&nbsp;Schematic overview of the road from biomarker discovery to clinical utilization. Biomarkers undergo thorough technical and analytical scrutiny during development before clinical qualification and utilization. The highlighted parameters reflect the CLSI guidelines for assay development and validation.<\/em><\/figcaption><\/figure><\/div>\n\n<section class=\"two-column group grey bg-grey\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Technical and analytical considerations<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>As development progresses, the clinical specificity and sensitivity of the biomarker is continuously evaluated. A great point to consider in this regard is the value of biobanking for retrospective analyses and potential discovery of novel biomarkers. During the development process, it is important to consider pre-analytical factors which can influence the process and integrity of the biomarker. These include status of the patient from which the sample is derived, biospecimen collection, handling and storage, and attention to freeze-thaw cycles of the sample.<\/p>\n<p>Analytical validation is characterized by analysis of the biomarker assay performance with the goal of ensuring a repeatable measurement with low variance and good sensitivity and specificity. Multiple parameters are assessed during this phase, including selectivity, accuracy, precision, recovery, sensitivity, reproducibility, and stability. Depending on the intended use of the biomarker assay certain standards must be met, such as the Clinical Laboratory Improvement Amendments (CLIA) for assays to be used for testing human samples.<\/p>\n<p>A biomarker validation according to the Clinical Laboratory and Standards Institute (CLSI) guidelines can further reduce the risk of a technical or analytical failure, thus increasing the utility of the biomarker assay, and is required for qualification and approval of the biomarker assay.<\/p>\n                <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/05\/nordic_bio32013.jpg\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Clinical qualification and utilization<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>Clinical qualification is based on evidence generated using the biomarker assay in a clinical setting, connecting the biomarker to biological and clinical endpoints. The Center for Drug Evaluation and Research (CDER) within the FDA has established formal guidance documents for the process of biomarker qualification, providing a framework aimed at regulatory approval for the use in drug development. Reaching regulatory approval, the biomarker assay can be officially used within the stated COU for assisting in decision making related to drug development.<\/p>\n<p>Clinical utilization is assessed by evaluating the performance of the biomarker assay in its stated COU, and includes procedures such as disease diagnosis, monitoring, treatment selection and prognosis. Formal qualification is not necessarily needed for a biomarker to provide clinical utility, but significantly enhances the clinical utility. Particularly when using the biomarker in the context of drug development and is required to support regulatory approval of a drug or when used as a surrogate endpoint.<\/p>\n                <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/05\/nordic_bio32141.jpg\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"two-column group grey bg-grey\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">From discovery to validation<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>It is important to consider that most biomarkers often do not make it through discovery, validation and implementation due to various reasons. Biomarker development may fail both because of technical and hypothesis-driven failures. The cost of bringing a biomarker to the market is extremely high, and often needs a co-development process including a drug.<\/p>\n<p>Many drugs unfortunately fail in development due to lack of demonstrating efficacy, and so do biomarker candidates. In addition, changing clinical practice is a big hurdle, which takes many years, thus the return-of-investment from investing in both biomarkers and drug development is often lacking for biomarkers with limited investments.<\/p>\n<p>Additionally, it is easier to do biomarker discovery with a bigger platform such as SomaScan and Olink, but the investment taken from discovery to refinement over many studies, with CLSI technical validation along the way (Figure 1), is long and costly. Moreover, submission to regulatory agencies in relation to formal qualification of biomarkers is long, expensive and requires substantial data to be generated, which further complicates the possibilities for smaller companies and research groups.<\/p>\n                <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/05\/nordic_bio32302.jpg\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col xl:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Get in touch<\/h2>\n                 \n\n                <\/div>\n                <div class=\"xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <div class=\"mb-10\">\n                        <div class=\"mb-4\">\n                            Are you interested in exploring collaboration possibilities?\u2028Enter your information in the form and a representative will contact you shortly.                        <\/div>\n                                                    <div class=\"flex flex-col gap-1 links\">\n                                                                    <a class=\"flex underline transition ease-out duration-200 hover:text-turquoise hover:after:bg-turquoise after:content-[''] after:[mask-image:url(..\/..\/nordicbioscience\/img\/icons\/hyperlink.svg)] after:w-4 after:h-4 after:bg-navy after:block\" href=\"#\" target=\"\">+45 4452 5252<\/a>\n                                                                    <a class=\"flex underline transition ease-out duration-200 hover:text-turquoise hover:after:bg-turquoise after:content-[''] after:[mask-image:url(..\/..\/nordicbioscience\/img\/icons\/hyperlink.svg)] after:w-4 after:h-4 after:bg-navy after:block\" href=\"mailto:bd@nordicbioscience.com?subject=General%20Inquiry\" target=\"_blank\">Contact us via email!<\/a>\n                                                            <\/div>\n                                            <\/div>\n                    \n<div class=\"wpcf7 no-js\" id=\"wpcf7-f170-o1\" lang=\"en-US\" dir=\"ltr\" data-wpcf7-id=\"170\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/wp-json\/wp\/v2\/pages\/2357#wpcf7-f170-o1\" method=\"post\" class=\"wpcf7-form init\" aria-label=\"Contact form\" novalidate=\"novalidate\" data-status=\"init\">\n<fieldset class=\"hidden-fields-container\"><input type=\"hidden\" name=\"_wpcf7\" value=\"170\" \/><input type=\"hidden\" name=\"_wpcf7_version\" value=\"6.1.3\" \/><input type=\"hidden\" name=\"_wpcf7_locale\" value=\"en_US\" \/><input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f170-o1\" \/><input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/><input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/><input type=\"hidden\" name=\"_wpcf7_recaptcha_response\" value=\"\" \/>\n<\/fieldset>\n<div class=\"row\">\n<label>Your scientific area\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"scientific-area\"><select class=\"wpcf7-form-control wpcf7-select wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" name=\"scientific-area\"><option value=\"\">Select area<\/option><option value=\"Cardiology\">Cardiology<\/option><option value=\"Dermatology\">Dermatology<\/option><option value=\"Gastroenterology\">Gastroenterology<\/option><option value=\"Hepatology\">Hepatology<\/option><option value=\"Nephrology\">Nephrology<\/option><option value=\"Neurology\">Neurology<\/option><option value=\"Obesity\">Obesity<\/option><option value=\"Pulmonology\">Pulmonology<\/option><option value=\"Rheumatology\">Rheumatology<\/option><option value=\"Multi-organ\/Other\">Multi-organ\/Other<\/option><\/select><\/span>\n    <\/label>\n<label>Your request\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"request\"><select class=\"wpcf7-form-control wpcf7-select wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" name=\"request\"><option value=\"\">Select request<\/option><option value=\"General inquiry\">General inquiry<\/option><option value=\"Biomarkers\">Biomarkers<\/option><option value=\"Laboratory\">Laboratory<\/option><option value=\"Something else\">Something else<\/option><\/select><\/span>\n    <\/label>\n<\/div>\n\n\n<div class=\"row\">\n<label> First name\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"first-name\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" autocomplete=\"name\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Jane\" value=\"\" type=\"text\" name=\"first-name\" \/><\/span> <\/label>\n<label> Last name\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"last-name\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" autocomplete=\"name\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Doe\" value=\"\" type=\"text\" name=\"last-name\" \/><\/span> <\/label>\n<\/div>\n<label> Email\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"your-email\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-email wpcf7-validates-as-required wpcf7-text wpcf7-validates-as-email\" autocomplete=\"email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Jane@doe.com\" value=\"\" type=\"email\" name=\"your-email\" \/><\/span> <\/label>\n\n<label> Company\/Organization (optional)\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"company-organization\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" autocomplete=\"company\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Your amazing company\" value=\"\" type=\"text\" name=\"company-organization\" \/><\/span> <\/label>\n\n<label> Phone (optional)\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"phonenumber\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-tel wpcf7-text wpcf7-validates-as-tel\" autocomplete=\"tel\" aria-invalid=\"false\" placeholder=\"+45 12 23 34 45\" value=\"\" type=\"tel\" name=\"phonenumber\" \/><\/span> <\/label>\n\n<label> Your message (optional)\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"your-message\"><textarea cols=\"40\" rows=\"10\" maxlength=\"2000\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\" placeholder=\"Non\u2010binding inquiry; BD team will follow up with details.\" name=\"your-message\"><\/textarea><\/span> <\/label>\n\n<span class=\"wpcf7-form-control-wrap\" data-name=\"acceptance\"><span class=\"wpcf7-form-control wpcf7-acceptance\"><span class=\"wpcf7-list-item\"><label><input type=\"checkbox\" name=\"acceptance\" value=\"1\" aria-invalid=\"false\" \/><span class=\"wpcf7-list-item-label\">Nordic Bioscience ApS and its non-profit partner, The Extracellular Matrix Pharmacology Congress, can contact me by email with news on research, events, products, and similar. I can always withdraw my consent at any time. This site is protected by reCAPTCHA and the Google\n    <a href=\"https:\/\/policies.google.com\/privacy\">Privacy Policy<\/a> and\n    <a href=\"https:\/\/policies.google.com\/terms\">Terms of Service<\/a> apply.<\/span><\/label><\/span><\/span><\/span>\n\n\n\n<input class=\"wpcf7-form-control wpcf7-submit has-spinner\" type=\"submit\" value=\"Submit request\" \/><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n                <\/div>\n            <\/div>\n                    <\/article>\n        <figure class=\"flex-1 hidden h-auto rounded-md xl:block -order-1 xl:order-none xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover h-full\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2024\/12\/8f7ca89c8e79f07c1ca8c413139cd495-scaled.jpeg\" alt=\"a person wearing a blue lab coat, gloves, and safety glasses, working in a laboratory setting. They are using a pipette to transfer liquid into small bottles, surrounded by lab equipment and vials.\">\n        <\/figure>   \n   <\/div>\n<\/section>\n\n\n<section class=\"call-to-action\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col\">\n        <article style=\"background-image: url()\" class=\"bg-cover shadow-main flex overflow-clip flex-col justify-between px-5 py-10 rounded-md bg-gray-600 xl:p-40 text-column xl:rounded-xl after:content-[''] after:block after:inset-0 relative after:absolute after:bg-gradient-to-b from-black\/0 to-black\">\n            <div class=\"max-w-[900px] mx-auto relative z-10\">\n                <div class=\"text-center text-balance\">\n                     \n                    <\/div>\n                    <div class=\"mb-8 text-center !text-fontlight\/90 body-text text-balance\">\n                        <p><em>Nordic Bioscience\u2019s assays, products, and services are for research use only and are not intended for medical or diagnostic purposes<\/em>.<\/p>\n                    <\/div>\n                    \n                                            <\/div>\n                    <\/article>\n                <\/div>\n            <\/section>\n\n\n\n<section id=\"news-section\" class=\"news-events\">\n    <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex flex-col xl:flex-row gap-4 xl:gap-20 xl:\">\n       \n        <!-- NEWS COLUMN -->\n        <article class=\"flex-1 news-column\">\n            <h2 class=\"mb-8 font-bold text-d-title-md text-navy\">News<\/h2>\n                                                <div class=\"pb-4 mb-4 border-b border-gray-200 border-solid news-card\">\n                        <a href=\"https:\/\/www.nordicbioscience.com\/news\/autumn-conference-season-q3-q4\/\">\n                            <h2 class=\"mb-1 font-bold transition duration-200 ease-out text-navy text-m-title-sm xl:text-d-title-sm xl:hover:text-turquoise\">Autumn Conference Season (Q3-Q4)<\/h2>\n                            <p class=\"mb-3 transition duration-200 ease-out text-body-sm text-blue xl:hover:text-turquoise\">September 10, 2025<\/p>\n                       <\/a>\n                        <a class=\"flex items-center after:bg-fontdark text-fontdark font-poppins gap-2 transition ease-out duration-200 xl:hover:text-turquoise after:content-[''] after:[mask-image:url('..\/img\/icons\/arrow_right_dark.svg')] after:[mask-size:contain] after:block after:w-4 after:h-4 xl:hover:after:bg-turquoise after:transition after:ease-out after:duration-200\" href=\"https:\/\/www.nordicbioscience.com\/news\/autumn-conference-season-q3-q4\/\">Read article<\/a>\n                    <\/div>\n                                    <div class=\"pb-4 mb-4 border-b border-gray-200 border-solid news-card\">\n                        <a href=\"https:\/\/www.nordicbioscience.com\/news\/nordic-bioscience-launches-new-website\/\">\n                            <h2 class=\"mb-1 font-bold transition duration-200 ease-out text-navy text-m-title-sm xl:text-d-title-sm xl:hover:text-turquoise\">Nordic Bioscience Launches New Website<\/h2>\n                            <p class=\"mb-3 transition duration-200 ease-out text-body-sm text-blue xl:hover:text-turquoise\">June 16, 2025<\/p>\n                       <\/a>\n                        <a class=\"flex items-center after:bg-fontdark text-fontdark font-poppins gap-2 transition ease-out duration-200 xl:hover:text-turquoise after:content-[''] after:[mask-image:url('..\/img\/icons\/arrow_right_dark.svg')] after:[mask-size:contain] after:block after:w-4 after:h-4 xl:hover:after:bg-turquoise after:transition after:ease-out after:duration-200\" href=\"https:\/\/www.nordicbioscience.com\/news\/nordic-bioscience-launches-new-website\/\">Read article<\/a>\n                    <\/div>\n                                    <div class=\"pb-4 mb-4 border-b border-gray-200 border-solid news-card\">\n                        <a href=\"https:\/\/www.nordicbioscience.com\/news\/press-release-nordic-bioscience-launches-novel-endotrophin-assay\/\">\n                            <h2 class=\"mb-1 font-bold transition duration-200 ease-out text-navy text-m-title-sm xl:text-d-title-sm xl:hover:text-turquoise\">PRESS RELEASE: Nordic Bioscience Launches Novel Endotrophin Assay<\/h2>\n                            <p class=\"mb-3 transition duration-200 ease-out text-body-sm text-blue xl:hover:text-turquoise\">May 16, 2025<\/p>\n                       <\/a>\n                        <a class=\"flex items-center after:bg-fontdark text-fontdark font-poppins gap-2 transition ease-out duration-200 xl:hover:text-turquoise after:content-[''] after:[mask-image:url('..\/img\/icons\/arrow_right_dark.svg')] after:[mask-size:contain] after:block after:w-4 after:h-4 xl:hover:after:bg-turquoise after:transition after:ease-out after:duration-200\" href=\"https:\/\/www.nordicbioscience.com\/news\/press-release-nordic-bioscience-launches-novel-endotrophin-assay\/\">Read article<\/a>\n                    <\/div>\n                            \n            <!-- NEWS Pagination -->\n                            <div class=\"flex items-center justify-between pagination\">\n                    <!-- Prev -->\n                                            <span class=\"flex items-center justify-center w-10 h-10 border border-solid rounded-full opacity-50 pagination-prev bg-buttonfill border-turquoise disabled\">\n                            <img decoding=\"async\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/themes\/nordicbioscience\/img\/icons\/arrow_left_dark.svg\">\n                        <\/span>\n                    \n                    <!-- Page numbers -->\n                    <div class=\"flex gap-1 page-numbers-wrapper\">\n                        <span aria-current=\"page\" class=\"page-numbers current\">1<\/span>\n<a class=\"page-numbers\" href=\"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/pages\/2357\/?paged_news=2#news-section\">2<\/a>\n<a class=\"page-numbers\" href=\"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/pages\/2357\/?paged_news=3#news-section\">3<\/a>\n<span class=\"page-numbers dots\">&hellip;<\/span>\n<a class=\"page-numbers\" href=\"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/pages\/2357\/?paged_news=15#news-section\">15<\/a>                    <\/div>\n\n                    <!-- Next -->\n                                            <a href=\"\/wp-json\/wp\/v2\/pages\/2357?paged_news=2#news-section\" class=\"flex items-center justify-center w-10 h-10 border border-solid rounded-full pagination-next bg-buttonfill border-turquoise\">\n                            <img decoding=\"async\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/themes\/nordicbioscience\/img\/icons\/arrow_right_dark.svg\">\n                        <\/a>\n                                    <\/div>\n                    <\/article>\n\n        <!-- EVENTS COLUMN -->\n        <article class=\"flex-1 h-full mb-10 -order-1 xl:order-1 events-column xl:rounded-xl\">\n            <h2 class=\"mb-8 font-bold text-d-title-md text-navy\">Upcoming events<\/h2>\n            <div class=\"flex flex-col gap-5 flex-nowrap xl:block\">\n                                    <div class=\"w-full\">\n                        <p class=\"text-blue text-body-sm\">No upcoming events<\/p>\n                    <\/div>\n                            <\/div>\n\n            <!-- EVENTS Pagination -->\n                    <\/article>\n    <\/div>\n<\/section>\n\n\n\n<!--\ninitialize dynaimic classes\nxl:grid-cols-4\nxl:grid-cols-3\n-->\n<section class=\"overflow-hidden slider\">\n    <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto\">\n        <div>\n                            <h2 class=\"mb-1 small-title text-blue\">News, events, and other resources<\/h2>\n                                    <h3 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg text-navy\">Discover Nordic Bioscience<\/h3>\n                                 \n\n        <\/div>\n        <div class=\"swiper-posts !overflow-visible 2xl:!overflow-hidden rounded-md\">\n                            <ul class=\"mb-5 xl:mb-8 swiper-wrapper\">\n                                                                <li class=\"swiper-slide\">\n                            <a class=\"group\" href=\"https:\/\/www.nordicbioscience.com\/about\/news-and-events\/\">\n                                <figure class=\"aspect-[4\/3] bg-fontlight overflow-clip rounded-md mb-3 before:content-[''] before:block before:absolute relative before:inset-0 xl:group-hover:before:bg-turquoise before:transition before:duration-200 before:ease-out before:mix-blend-multiply before:z-10\">\n                                    <img decoding=\"async\" class=\"object-cover w-full h-full transition duration-200 ease-out scale-105 group-hover:scale-100 \" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/649561a6808da-300x225.webp\" alt=\"\">\n                                <img decoding=\"async\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/themes\/nordicbioscience\/img\/icons\/hover-arrow.svg\" class=\"absolute z-20 transition duration-200 ease-out -translate-x-1\/2 -translate-y-1\/2 opacity-0 xl:group-hover:opacity-100 arrow top-1\/2 left-1\/2\">\n                                <\/figure>\n                                <h2 class=\"mb-[4px] text-body-sm text-blue\">\n                                    News &amp; Events                                <\/h2>\n                                <h3 class=\"font-bold xl:text-d-xs-title text-m-title-xs text-navy\">\n                                    Get up to date with our news and events                                <\/h3>\n                            <\/a>\n                        <\/li>\n                                                                                    <li class=\"swiper-slide\">\n                            <a class=\"group\" href=\"https:\/\/www.nordicbioscience.com\/blog\/\">\n                                <figure class=\"aspect-[4\/3] bg-fontlight overflow-clip rounded-md mb-3 before:content-[''] before:block before:absolute relative before:inset-0 xl:group-hover:before:bg-turquoise before:transition before:duration-200 before:ease-out before:mix-blend-multiply before:z-10\">\n                                    <img decoding=\"async\" class=\"object-cover w-full h-full transition duration-200 ease-out scale-105 group-hover:scale-100 \" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/publications-hero-300x188.webp\" alt=\"\">\n                                <img decoding=\"async\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/themes\/nordicbioscience\/img\/icons\/hover-arrow.svg\" class=\"absolute z-20 transition duration-200 ease-out -translate-x-1\/2 -translate-y-1\/2 opacity-0 xl:group-hover:opacity-100 arrow top-1\/2 left-1\/2\">\n                                <\/figure>\n                                <h2 class=\"mb-[4px] text-body-sm text-blue\">\n                                    Blog                                <\/h2>\n                                <h3 class=\"font-bold xl:text-d-xs-title text-m-title-xs text-navy\">\n                                    Browse our articles, webinars, and videos                                <\/h3>\n                            <\/a>\n                        <\/li>\n                                                                                                                            <li class=\"swiper-slide\">\n                            <a class=\"group\" href=\"https:\/\/www.nordicbioscience.com\/\">\n                                <figure class=\"aspect-[4\/3] bg-fontlight overflow-clip rounded-md mb-3 before:content-[''] before:block before:absolute relative before:inset-0 xl:group-hover:before:bg-turquoise before:transition before:duration-200 before:ease-out before:mix-blend-multiply before:z-10\">\n                                    <img decoding=\"async\" class=\"object-cover w-full h-full transition duration-200 ease-out scale-105 group-hover:scale-100 \" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/scientificleadership-300x225.webp\" alt=\"\">\n                                <img decoding=\"async\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/themes\/nordicbioscience\/img\/icons\/hover-arrow.svg\" class=\"absolute z-20 transition duration-200 ease-out -translate-x-1\/2 -translate-y-1\/2 opacity-0 xl:group-hover:opacity-100 arrow top-1\/2 left-1\/2\">\n                                <\/figure>\n                                <h2 class=\"mb-[4px] text-body-sm text-blue\">\n                                    Nordic Bioscience                                <\/h2>\n                                <h3 class=\"font-bold xl:text-d-xs-title text-m-title-xs text-navy\">\n                                    Explore our growing library of 750+ scientific publications                                <\/h3>\n                            <\/a>\n                        <\/li>\n                                                        <\/ul>\n               \n            <div class=\"flex items-center justify-center gap-2 xl:gap-4 lg:justify-start\">\n                <button class=\"bg-buttonfill border-2 border-turquoise border-solid box-border !w-12 !h-12 rounded-full !static swiper-button-prev !mt-0 after:!content-[''] after:![mask-image:url(..\/..\/nordicbioscience\/img\/icons\/arrow_left_dark.svg)] after:!bg-navy after:!w-6 after:!h-6 after:block after:[mask-size:contain]\" aria-label=\"Previous slide button\"><\/button>\n                <button class=\"bg-buttonfill border-2 border-turquoise border-solid box-border !w-12 !h-12 rounded-full !static swiper-button-next !mt-0 after:!content-[''] after:![mask-image:url(..\/..\/nordicbioscience\/img\/icons\/arrow_right_dark.svg)] after:!bg-navy after:!w-6 after:!h-6 after:block after:[mask-size:contain]\" aria-label=\"Next slide button\"><\/button>\n            <\/div>\n        <\/div>\n   <\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":1803,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-2357","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/pages\/2357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/comments?post=2357"}],"version-history":[{"count":4,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/pages\/2357\/revisions"}],"predecessor-version":[{"id":7403,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/pages\/2357\/revisions\/7403"}],"up":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/pages\/1803"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=2357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}