{"id":2224,"date":"2025-02-01T18:53:30","date_gmt":"2025-02-01T18:53:30","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?page_id=2224"},"modified":"2025-06-01T14:32:44","modified_gmt":"2025-06-01T14:32:44","slug":"fib-nit","status":"publish","type":"page","link":"https:\/\/www.nordicbioscience.com\/technology\/fib-nit\/","title":{"rendered":"The FIB-NIT\u2122 Biomarker Panel"},"content":{"rendered":"<section class=\"hero relative z-[2] lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto\">\n    <div style=\"background-image: linear-gradient(0deg, rgba(0,0,0,1) 0%, rgba(0,0,0,0) 100%), url(https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/shutterstock_1470753386-scaled.webp)\" class=\"shadow-main overlay flex flex-col min-h-[80svh] lg:min-h-[60svh] justify-end py-10 p-5 lg:p-8 xl:p-10 bg-cover rounded-md lg:rounded-lg xl:rounded-xl xl:min-h-[800px]\">\n        <article>\n                            <h1 class=\"mb-4 font-bold text-white xl-mb-6 text-m-title-lg lg:text-d-title-xl font-poppins\">The FIB-NIT\u2122 Biomarker Panel<\/h1>\n                                                    <p class=\"mb-8 text-gray-300 xl:mb-10 xl:w-1\/2 font-poppins\">The FIB-NIT\u2122 Biomarker Panel provides a non-invasive assessment of fibrosis by measuring key ECM biomarkers\u2014NordicPRO-C3\u00ae, NordicPRO-C6\u2122, and NordicCTX-III\u2122. It helps track fibrogenesis, fibrolysis, and disease progression, supporting patient selection and treatment monitoring in clinical trials.<\/p>\n                                                <div class=\"flex flex-wrap gap-6 xl:mt-8 group light-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/hepatic-diseases\/biomarker-panel\/fib-nit-panel-fibrosis-non-invasive-tests\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Order today            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n    <\/div>\n<\/section>\n\n\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">FIB-NIT\u2122\u2014your companion in fibrosis research<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p>FIB-NIT\u2122 (Fibrosis Non-Invasive Tests) is an innovative panel that utilizes biomarkers of fibrotic processes.<\/p>\n<p>These biomarkers have been proven to associate with superior pharmacodynamic and supportive prognostic performance to investigate dynamics within fibrotic diseases, including understanding drug efficacy in such indications \u2014demonstrated in over 100 publications in relevant and peer-reviewed scientific journals.<\/p>\n<p>The FIB-NIT\u2122 panel consists of the fibrogenesis <a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c3-nordicpro-c3\/\">nordicPRO-C3\u2122<\/a>, the fibrolysis <a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/ctx-iii\/\">nordicCTX-III\u2122<\/a>, and the outcome risk\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker\/pro-c6\/\">nordicPRO-C6\u2122<\/a>\u00a0biomarkers.<\/p>\n                <\/div>\n                                    <div class=\"mt-8 mb-4 xl:mb-8 links\">\n                        <h3 class=\"mb-2 text-blue group-[.dark]:text-fontlight text-body-sm\">Biomarkers in the FIB-NIT\u2122 panel<\/h3>\n                        <ul class=\"flex flex-wrap gap-2\">\n                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c3\/\" target=\"_blank\">PRO-C3 (nordicPRO-C3\u2122)<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c6\/\" target=\"_blank\">PRO-C6 (nordicPRO-C6\u2122)<\/a>\n                                    <\/li>\n                                                                                                                                 <li>\n                                        <a class=\"inline-block transition ease-out duration-100 px-[6px] py-1 group-[.dark]:bg-[#434343] group-[.dark]:text-fontlight text-body-sm bg-border rounded-sm text-blue xl:hover:bg-petroleum xl:hover:text-fontlight group-[.dark]:xl:hover:bg-petroleum group-[.dark]:xl:hover:text-fontlight\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/ctx-iii\/\" target=\"_blank\">CTX-III (nordicCTX-III\u2122)<\/a>\n                                    <\/li>\n                                                                                    <\/ul>\n                    <\/div>\n                                <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/01\/shutterstock_1470753386-scaled.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"h-ecm-biomarkers-and-fib-nit\">ECM biomarkers and FIB-NIT\u2122<\/h2>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <p><a href=\"https:\/\/www.nordicbioscience.com\/blog\/extracellular-matric-animation\/\">Biomarkers of the ECM<\/a>, especially those based on collagens, are efficient tools to investigate fibrotic processes. Collagens are major components of ECM that are affected by fibrosis in the injured tissue, which produce unique fragments. These unique fragments, called neo-epitopes, are released in the bloodstream where they can be non-invasively measured by the\u00a0Nordic ProteinFingerPrint Biomarker Technology\u2122 to understand ECM turnover disruption.<\/p>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c3\/\">NordicPRO-C3<em>\u2122<\/em>\u00a0(PRO-C3)<\/a><em>\u00a0<\/em>and\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c6\/\">NordicPRO-C6<em>\u2122<\/em>\u00a0(PRO-C6)<\/a> are both associated\u00a0with fibrogenesis and excessive production of ECM, while the biomarker <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/ctx-iii\/\">NordicCTX-III<em>\u2122\u00a0<\/em>(CTX-III)<\/a> is related to fibrolysis and degradation of fibrotic tissue.<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <p>The\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/hepatic-diseases\/biomarker-panel\/fib-nit-panel-fibrosis-non-invasive-tests\/\">FIB-NIT\u2122 panel<\/a> includes three of the most prominent Nordic Bioscience developed biomarkers to understand fibrogenesis, fibrolysis and risk of outcome. When combined, these three biomarkers provide a unique solution to monitor the mass balance of ECM remodeling as well as fibrosis dynamics which can contribute to accelerated clinical trials.<\/p>\n<p>FIB-NIT\u2122 achieves this by helping with patient selection and inclusion, identification of treatment responders, assessment and prediction of drug response without the need for invasive procedures like biopsy; or the use of expensive noninvasive screening tests that are commonly used in the clinical practice.<\/p>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><a href=\"https:\/\/www.nordicbioscience.com\/nordic-proteinfingerprint-technology\/\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"640\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit_schematic_overview_no_image_no_plus_panel_-_no_markers-1024x640.webp\" alt=\"\" class=\"wp-image-2233\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit_schematic_overview_no_image_no_plus_panel_-_no_markers-1024x640.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit_schematic_overview_no_image_no_plus_panel_-_no_markers-300x188.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit_schematic_overview_no_image_no_plus_panel_-_no_markers-768x480.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit_schematic_overview_no_image_no_plus_panel_-_no_markers.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">NordicPRO-C3\u2122, a true marker of fibrogenesis<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c3\/\"><strong>NordicPRO-C3\u2122 <\/strong><\/a>(ADAMTS2 mediated release of the N-terminal pro-peptide of type III collagen) measures the formation of type III collagen which has been shown to be a key process behind fibrogenesis development and progression in different organs and tissues (liver, lung, kidney, heart, intestines, skin). Concentrations of PRO-C3 give an estimation of the level of active fibrogenesis and can be useful as a clinical research tool to identify patients at risk to develop outcomes and predict the incidence of liver related events.<\/p>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c3\/\">PRO-C3<\/a>, being\u00a0a neoepitope\u00a0differs from PIIINP,\u00a0as the former is formation specific, while the latter measures both formation and degradation of type III collagen, yielding a less precise measurement.<\/p>\n<p><em><strong>Figure 1<sup><a title=\"Reference: Nielsen, Leeming &amp; Guha et al, JHEP Rep 2023.\" href=\"https:\/\/www.jhep-reports.eu\/article\/S2589-5559(23)00074-5\/pdf\" target=\"_blank\" rel=\"noopener noreferrer\">[1]<\/a><\/sup>.<\/strong>\u00a0PRO-C3 levels allow to stratify patients with advanced liver fibrosis (F4) with a higher degree of active fibrogenesis and, consequently, at a higher risk to develop outcomes.<\/em><\/p>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/hepatic-diseases\/biomarker-panel\/fib-nit-panel-fibrosis-non-invasive-tests\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"_blank\">\n            Order FIB-NIT\u2122 now            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-patient-stratification_v3.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure class=\"wp-block-image aligncenter size-large\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-drug-response-and-pharmacodynamic.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2226 size-full\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-drug-response-and-pharmacodynamic.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-drug-response-and-pharmacodynamic.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-drug-response-and-pharmacodynamic-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-drug-response-and-pharmacodynamic-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-drug-response-and-pharmacodynamic-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Table 1.<\/strong> PRO-C3 levels dynamically change upon anti-fibrotic treatment with Efruxifermin allowing to monitor drug response and pharmacodynamics in phase 2 MASH intervention studies.<\/em><\/figcaption><\/figure>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure class=\"wp-block-image aligncenter size-large\"><a href=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-levels-dynamic-anti-fibrotic-treatment.webp\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2227 size-full\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-levels-dynamic-anti-fibrotic-treatment.webp\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-levels-dynamic-anti-fibrotic-treatment.webp 1280w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-levels-dynamic-anti-fibrotic-treatment-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-levels-dynamic-anti-fibrotic-treatment-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c3-levels-dynamic-anti-fibrotic-treatment-768x432.webp 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/a><figcaption class=\"wp-element-caption\"><em><strong>Table 2.<\/strong> PRO-C3 levels allow to monitor drug response and pharmacodynamics in phase 2 and 3 metabolic intervention studies with focus in MASH and obesity.<\/em><\/figcaption><\/figure>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"mailto:bd@nordicbioscience.com?subject=FIB-NIT%E2%84%A2%20inquiry\">Interested in the panel? Get in touch!<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<section class=\"two-column-text group  bg-\">\n   <div class=\"inner lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:flex-row lg:gap-8 xl:gap-10 flex-col\">\n        <div class=\"w-full left-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <h2>NordicPRO-C6\u2122, a marker of outcome<\/h2>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c6\/\">NordicPRO-C6\u2122<\/a>\u00a0(C-terminal of type VI collagen \u03b13 chain; also known as Endotrophin) measures the formation of type VI collagen and the signaling molecule <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/endotrophin\/\">Endotrophin<\/a> which correlates to fibrogenesis, fibroblast activity and, to metabolic processes.<\/p>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/pro-c6\/\">PRO-C6<\/a> acts as a driver of fibro-inflammatory processes, providing an efficient tool to predict outcomes (risk of cardiovascular events,\u00a0HFpEF pathology; mortality; disease progression) in many different fibrotic diseases affecting liver, heart, kidneys, and the gastrointestinal system.<\/p>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/endotrophin\/\">Endotrophin<\/a> has a major role for the development and progression of metabolic disorders and is highly correlated to a pro-fibrotic, pro-inflammatory and angiogenesis endotype, allowing to <a href=\"https:\/\/www.nordicbioscience.com\/nordicpro-c6-for-trial-enrichment-in-hfpef-3\/\">identify patients with preserved ejection fraction (HFpEF)<\/a> that are at risk of developing cardiovascular events and at risk of death.<\/p>\n<p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/endotrophin\/\">Endotrophin<\/a> measured through nordicPRO-C6\u2122 levels has shown prognostic potential for predicting mortality in many different pathological conditions such as liver, cardiovascular, metabolic, respiratory, kidney diseases, diabetes and\u00a0cancer.<\/p>\n        <\/div>\n        <div class=\"w-full right-column lg:w-1\/2 xl:w-1\/2 wysiwyg\">\n             <figure><\/figure>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2230 size-full\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c6-marker-of-collagen-vi-signaling-activity.webp\" alt=\"\" width=\"1244\" height=\"718\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c6-marker-of-collagen-vi-signaling-activity.webp 1244w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c6-marker-of-collagen-vi-signaling-activity-300x173.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c6-marker-of-collagen-vi-signaling-activity-1024x591.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c6-marker-of-collagen-vi-signaling-activity-768x443.webp 768w\" sizes=\"auto, (max-width: 1244px) 100vw, 1244px\" \/><figcaption class=\"wp-element-caption\"><em><strong>Figure 2<\/strong>. PRO-C6 as a marker of type VI collagen formation and Endotrophin signaling activity.<\/em><\/figcaption><\/figure>\n        <\/div>   \n    <\/div>\n<\/section>\n\n\n<div class=\"wp-block-image\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6924f83163ab5&quot;}\" data-wp-interactive=\"core\/image\" class=\"aligncenter size-full wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"984\" height=\"533\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on-async--click=\"actions.showLightbox\" data-wp-on-async--load=\"callbacks.setButtonStyles\" data-wp-on-async-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c6-abnormal-metabolic-activity.webp\" alt=\"\" class=\"wp-image-2229\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c6-abnormal-metabolic-activity.webp 984w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c6-abnormal-metabolic-activity-300x163.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-pro-c6-abnormal-metabolic-activity-768x416.webp 768w\" sizes=\"auto, (max-width: 984px) 100vw, 984px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Enlarge\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on-async--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><figcaption class=\"wp-element-caption\"><em><strong>Figure 3<sup><a href=\"https:\/\/evidence.nejm.org\/doi\/full\/10.1056\/EVIDoa2200091\" target=\"_blank\" rel=\"noreferrer noopener\">[2]<\/a><\/sup>.<\/strong>&nbsp;PRO-C6 levels indicate abnormal&nbsp;<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solutions\/metabolic-dysregulation\/\" data-type=\"biomarker-solutions\" data-id=\"781\">metabolic activity<\/a>&nbsp;and can be used for identification of patients with cardiovascular (CV) diseases at risk of heart failure and death related to cardiovascular events. PRO-C6 outperforms standard biomarkers and scores used in the clinic for prognosis of cardiovascular diseases.&nbsp;Primary endpoint: CV death from CV causes, aborted cardiac arrest or hospitalization for HF. Data adjusted for age, gender, race, diabetes, history of MI &amp; glomerular filtration rate (GFR).<\/em><\/figcaption><\/figure><\/div>\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-grey\n        bg-dark\n        lg:flex-row-reverse\n        lg:flex-row\n        -->\n   <div class=\"inner items-center lg:p-8 xl:p-10 p-5 max-w-[1440px] mx-auto flex gap-4 lg:gap-8 xl:gap-10 flex-col lg:flex-row\">\n        <article class=\"flex flex-col justify-between flex-1 text-column lg:py-8 xl:py-10\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-md group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">NordicCTX-III\u2122, a marker of fibrosis resolution and endotyping<\/h2>\n                 \n\n                <\/div>\n                <div class=\"wysiwyg mb-8 xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/ctx-iii\/\"><strong>NordicCTX-III\u2122<\/strong><\/a>,\u00a0(fragment of MMP degraded crosslinked type III collagen) measures the proteolytic degradation of cross-linked type III collagen, a process which indicates fibrolysis and fibrosis resolution. Interventions based on drug treatment and lifestyle changes can stimulate the production of proteolytic enzymes that cleave ECM excess, especially type III collagen, in fibrotic conditions, leading to improvement of fibrosis via resolution.<\/p>\n<p>By measuring <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/ctx-iii\/\">CTX-III<\/a>,\u00a0we may\u00a0assess patients who have progressive, stable or regressive fibrosis.\u00a0<a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/hepatic\/masld-sld-and-mash\/\">MASLD<\/a>\u00a0patients with higher concentrations of CTX-III have higher rates of fibrolysis and are more likely to present a more regressive endotype of fibrosis following interventions focused on improving liver health, for example, weight loss due to bariatric surgery.<\/p>\n<p style=\"text-align: right;\"><em><strong>Figure 4<sup><a title=\"Reference: Pehrsson et al. Liver International 42.7 (2022): 1605-1617.\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/liv.15270\" target=\"_blank\" rel=\"noopener noreferrer\">[3]<\/a><\/sup>.\u00a0<\/strong><\/em><em>CTX-III separates regressors from stable and progressor patients.<\/em><\/p>\n                <\/div>\n                                <\/div>\n                                    <div class=\"flex flex-wrap gap-6 xl:mt-8 group dark-button\">\n                                                                                            <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/therapeutic-area\/hepatic-diseases\/biomarker-panel\/fib-nit-panel-fibrosis-non-invasive-tests\/\" class=\"group button fill flex items-center font-poppins px-6 py-4 gap-2 transition ease-out duration-200 \n            bg-buttonfill \n            xl:hover:bg-petroleum \n            xl:hover:border-petroleum \n            group-[.dark-button]:text-fontdark \n            group-[.light-button]:text-fontlight\n            xl:group-[.dark-button]:hover:text-fontlight\n            border-2 border-turquoise border-solid rounded-full\n            xl:hover:[&#038;_svg_path]:fill-fontlight\n            group\/button\n            \" target=\"\">\n            Order FIB-NIT\u2122            <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                <path class=\"group-[.dark-button]:fill-fontdark group-[.light-button]:fill-fontlight xl:group-hover\/button:!fill-fontlight xl:group-hover\/subtlebutton:!fill-turquoise transition ease-out duration-200\" d=\"M8.0026 2.66699L7.0626 3.60699L10.7826 7.33366L2.66927 7.33366L2.66927 8.66699L10.7826 8.66699L7.05594 12.387L8.0026 13.3337L13.3359 8.00033L8.0026 2.66699Z\" fill=\"#F8F8F8\"\/>\n            <\/svg>\n            <!--group\/button-->\n        <\/a>\n                                                                            <\/div>\n                        <\/article>\n        <figure class=\"flex-1 rounded-md -order-1 xl:order-none  xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover min-h-full aspect-square\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/fib-nit-ctx-iii-regressive-fibrosisv2.webp\" alt=\"\">\n        <\/figure>   \n    <\/div>\n<\/section>\n\n\n<section class=\"accordion-block\">\n    <div class=\"inner xl:p-10 lg:p-8 lg:pb-0 xl:pb-0 p-5 pb-0 max-w-[1440px] mx-auto\">\n        <div>\n                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg text-navy\">FIB-NIT\u2122<\/h2>\n         \n        <\/div>\n            <ul class=\"accordion\">\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"1\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What is the FIB-NIT\u2122 Biomarker Panel used for?<\/span>\n                        <span id=\"icon-1\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-1\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p>The FIB-NIT\u2122 panel is a non-invasive diagnostic and research tool that measures three key ECM biomarkers\u2014NordicPRO-C3\u2122, NordicPRO-C6\u2122, and NordicCTX-III\u2122\u2014to assess fibrogenesis, fibrolysis, and fibrosis progression. It supports patient selection, treatment monitoring, and outcome prediction in clinical trials across various fibrotic diseases.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"2\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How does FIB-NIT\u2122 improve fibrosis research and clinical trials?<\/span>\n                        <span id=\"icon-2\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-2\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"434\" data-end=\"772\">FIB-NIT\u2122 enhances fibrosis research by enabling early identification of fast-progressing patients, detecting treatment responses sooner than traditional methods like biopsies or imaging, and offering insights into drug efficacy through dynamic ECM remodeling measurement.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"3\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">What diseases can the FIB-NIT\u2122 panel be applied to?<\/span>\n                        <span id=\"icon-3\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-3\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"774\" data-end=\"1074\">The biomarkers in the FIB-NIT\u2122 panel are applicable across multiple fibrotic conditions, including liver disease (MASH\/MASLD), heart failure (especially HFpEF), chronic kidney disease, pulmonary fibrosis, and metabolic and inflammatory disorders.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"4\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">How does NordicPRO-C3\u2122 differ from traditional fibrosis markers?<\/span>\n                        <span id=\"icon-4\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-4\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <p data-start=\"1076\" data-end=\"1405\">NordicPRO-C3\u2122 specifically measures the formation of type III collagen, a key process in fibrogenesis, providing a more precise assessment of active fibrosis compared to traditional markers like PIIINP, which do not distinguish between formation and degradation.<\/p>\n                        <\/div>\n                    <\/div>\n                <\/li>\n                            <!-- Accordion Item -->\n                <li>\n                    <button data-index=\"5\" \n                            class=\"flex items-center justify-between w-full py-5 font-bold text-m-title-sm xl:text-d-title-sm accordion-button text-navy\">\n                        <span class=\"text-start\">Why are NordicPRO-C6\u2122 and NordicCTX-III\u2122 important in fibrosis monitoring?<\/span>\n                        <span id=\"icon-5\" class=\"transition-transform duration-300 text-turquoise\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 16 16\" fill=\"currentColor\" class=\"w-4 h-4 xl:w-6 xl:h-6\">\n                                <path d=\"M8.75 3.75a.75.75 0 0 0-1.5 0v3.5h-3.5a.75.75 0 0 0 0 1.5h3.5v3.5a.75.75 0 0 0 1.5 0v-3.5h3.5a.75.75 0 0 0 0-1.5h-3.5v-3.5Z\" \/>\n                            <\/svg>\n                        <\/span>\n                    <\/button>\n                    <div id=\"content-5\" class=\"overflow-hidden transition-all duration-300 ease-in-out accordion-content max-h-0\">\n                        <div class=\"pb-5 text-sm max-w-[600px] text-blue\">\n                            <article class=\"text-token-text-primary w-full\" dir=\"auto\" data-testid=\"conversation-turn-104\" data-scroll-anchor=\"true\">\n<div class=\"text-base my-auto mx-auto py-5 [--thread-content-margin:--spacing(4)] @[37rem]:[--thread-content-margin:--spacing(6)] @[72rem]:[--thread-content-margin:--spacing(16)] px-(--thread-content-margin)\">\n<div class=\"[--thread-content-max-width:32rem] @[34rem]:[--thread-content-max-width:40rem] @[64rem]:[--thread-content-max-width:48rem] mx-auto flex max-w-(--thread-content-max-width) flex-1 text-base gap-4 md:gap-5 lg:gap-6 group\/turn-messages focus-visible:outline-hidden\" tabindex=\"-1\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"relative flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"22ffafb1-cad5-4a02-8943-6f10be3907cf\" data-message-model-slug=\"gpt-4o\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\n<div class=\"markdown prose dark:prose-invert w-full break-words dark\">\n<p data-start=\"1407\" data-end=\"1808\" data-is-last-node=\"\" data-is-only-node=\"\">NordicPRO-C6\u2122 reflects type VI collagen formation and Endotrophin activity, offering prognostic insights into outcomes like cardiovascular events and mortality. NordicCTX-III\u2122, on the other hand, indicates fibrolysis, helping identify patients with regressive fibrosis who may respond well to treatment or lifestyle changes.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"flex justify-start\">\n<div class=\"touch:-me-2 touch:-ms-3.5 -ms-2.5 -me-1 flex items-center p-1 select-none -mt-1 duration-[1.5s] focus-within:transition-none hover:transition-none pointer-events-none [mask-image:linear-gradient(to_right,black_33%,transparent_66%)] [mask-size:300%_100%] [mask-position:100%_0%] motion-safe:transition-[mask-position] group-hover\/turn-messages:pointer-events-auto group-hover\/turn-messages:[mask-position:0_0] group-focus-within\/turn-messages:pointer-events-auto group-focus-within\/turn-messages:[mask-position:0_0] has-data-[state=open]:pointer-events-auto has-data-[state=open]:[mask-position:0_0]\"><\/div>\n<\/div>\n<\/div>\n<div class=\"absolute\">\n<div class=\"flex items-center 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