{"id":19417,"date":"2025-01-30T10:21:00","date_gmt":"2025-01-30T10:21:00","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?p=19417"},"modified":"2025-08-26T12:36:57","modified_gmt":"2025-08-26T12:36:57","slug":"ecm-biomarkers-are-prognostic-in-primary-cholangitis-psc","status":"publish","type":"post","link":"https:\/\/www.nordicbioscience.com\/blog\/ecm-biomarkers-are-prognostic-in-primary-cholangitis-psc\/","title":{"rendered":"ECM Biomarkers Are Prognostic in Primary Cholangitis"},"content":{"rendered":"\n

Primary sclerosing cholangitis (PSC) is a chronic liver disease that leads to a damage of the bile duct, inflammation and fibrosis.<\/p>\n\n\n

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Fibrosis is a key histologic feature of immune-mediated liver diseases such as primary sclerosing cholangitis (PSC) <\/em><\/figcaption><\/figure><\/div>\n\n\n


As there is a need for non-invasive biomarkers that can accurately assess the disease severity and prognosis, this study evaluated the ability of extracellular matrix remodeling markers to diagnose fibrosis stage and predict PSC-related fibrosis progression and clinical events.

Our findings in this study showed that nordicPRO-C3\u2122<\/a> correlated with fibrosis stage, and nordicPRO-C3\u2122 and ELF score provided discrimination of advanced fibrosis and cirrhosis and predicted PSC-related events and fibrosis progression. Therefore, nordicPRO-C3\u2122<\/a> and ELF may be utilized for staging and can act as prognostic markers in PSC, contributing to improving current screening and treatment of immune-mediated liver diseases<\/a>.

Article: Serologic extracellular matrix remodeling markers are related to fibrosis stage and prognosis in a phase 2b trial of simtuzumab in patients with primary sclerosing cholangitis<\/em>
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Find the article here<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Primary sclerosing cholangitis (PSC) is a chronic liver disease that leads to a damage of the bile duct, inflammation and fibrosis. As there is a need for non-invasive biomarkers that can accurately assess the disease severity and prognosis, this study evaluated the ability of extracellular matrix remodeling markers to diagnose fibrosis stage and predict PSC-related […]<\/p>\n","protected":false},"author":4,"featured_media":19418,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[5191],"tags":[],"class_list":["post-19417","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2-minute-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/comments?post=19417"}],"version-history":[{"count":5,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19417\/revisions"}],"predecessor-version":[{"id":28172,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19417\/revisions\/28172"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media\/19418"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=19417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/categories?post=19417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/tags?post=19417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}