{"id":19400,"date":"2025-02-06T08:53:00","date_gmt":"2025-02-06T08:53:00","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?p=19400"},"modified":"2025-08-26T12:40:37","modified_gmt":"2025-08-26T12:40:37","slug":"blood-based-biomarkers-in-pulmonary-fibrosis","status":"publish","type":"post","link":"https:\/\/www.nordicbioscience.com\/blog\/blood-based-biomarkers-in-pulmonary-fibrosis\/","title":{"rendered":"Blood-Based Biomarkers in Pulmonary Fibrosis"},"content":{"rendered":"\n<p>Pulmonary fibrosis is a condition characterized by progressive lung scarring, resulting in a median survival of 3\u20135 years after diagnosis. However, the rate of lung function decline varies widely among patients with different aetiologies, posing substantial challenges in clinical management.&nbsp;<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"777\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/lunge-blau-neu-1024x777.webp\" alt=\"\" class=\"wp-image-27792\" style=\"width:772px;height:auto\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/lunge-blau-neu-1024x777.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/lunge-blau-neu-300x228.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/lunge-blau-neu-768x583.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/02\/lunge-blau-neu.webp 1060w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Pulmonary fibrosis is characterized by progressive lung scarring<\/em> <\/figcaption><\/figure><\/div>\n\n\n<p>Currently, no cure exists for pulmonary fibrosis, and pirfenidone and nintedanib, approved for idiopathic pulmonary fibrosis treatment, have partial effects in slowing disease progression and variable tolerability.<\/p>\n\n\n\n<p>This study aimed to classify patients with pulmonary fibrosis according to blood biomarkers to differentiate distinct disease patterns, known as endotypes.<br><br>Our findings showed that blood biomarker clustering in pulmonary fibrosis identified three distinct blood biomarker signatures associated with lung function and prognosis, suggesting unique pulmonary fibrosis biomarker patterns. These findings support the presence of pulmonary fibrosis endotypes with the potential to guide targeted therapy development.<\/p>\n\n\n\n<p><em>Article: Cluster analysis of blood biomarkers to identify molecular patterns in pulmonary fibrosis: assessment of a multicentre, prospective, observational cohort with independent validation<\/em><\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.thelancet.com\/journals\/lanres\/article\/PIIS2213-2600(24)00147-4\/fulltext\">Read the article<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Pulmonary fibrosis is a condition characterized by progressive lung scarring, resulting in a median survival of 3\u20135 years after diagnosis. However, the rate of lung function decline varies widely among patients with different aetiologies, posing substantial challenges in clinical management.&nbsp; Currently, no cure exists for pulmonary fibrosis, and pirfenidone and nintedanib, approved for idiopathic pulmonary [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":19401,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[5191],"tags":[],"class_list":["post-19400","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2-minute-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/comments?post=19400"}],"version-history":[{"count":5,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19400\/revisions"}],"predecessor-version":[{"id":28176,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19400\/revisions\/28176"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media\/19401"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=19400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/categories?post=19400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/tags?post=19400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}