{"id":19388,"date":"2025-02-19T08:30:00","date_gmt":"2025-02-19T08:30:00","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?p=19388"},"modified":"2025-08-26T12:42:31","modified_gmt":"2025-08-26T12:42:31","slug":"ecm-biomarkers-can-assess-disease-burden-and-treatment-response-in-ulcerative-colitis-uc","status":"publish","type":"post","link":"https:\/\/www.nordicbioscience.com\/blog\/ecm-biomarkers-can-assess-disease-burden-and-treatment-response-in-ulcerative-colitis-uc\/","title":{"rendered":"ECM Biomarkers in Ulcerative Colitis"},"content":{"rendered":"\n

Assessing disease burden and treatment response in ulcerative colitis (UC)<\/a> remains challenging, often leading to treatment withdrawal and unresolved disease activity. These challenges highlight the need for better, non-invasive biomarkers to monitor disease activity and predict treatment outcomes.<\/p>\n\n\n

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ECM biomarkers in ulcerative colitis <\/em><\/figcaption><\/figure><\/div>\n\n\n

In our recently published paper “Circulating Extracellular Matrix Products as Indicators of Disease Burden and Predictors of Disease Course in Ulcerative Colitis”, we identified C7M<\/a> (MMP-9\/13-degraded type VII collagen \u03b11-chain), nordicPRO-C3\u2122<\/a> (type III collagen formation), and PRO-C22<\/a> (turnover of type XXII collagen) as biomarkers of endoscopic disease severity and treatment response in UC.

We found that a combination of nordicPRO-C3\u2122<\/a> and PRO-C22<\/a> predicted endoscopic outcomes at week 24, while lower levels of C7M<\/a> and the C3M<\/a>\/nordicPRO-C3\u2122<\/a> ratio were associated with endoscopic response. Notably, this is the first time that MMP-mediated type VII collagen degradation has been linked to disease severity in UC, highlighting its potential role in epithelial damage and barrier dysfunction.

These biomarkers provide a non-invasive means to assess transmural disease activity and disease extent, addressing a critical gap in disease burden monitoring. Incorporating these biomarkers into clinical practice could improve UC<\/a> management by refining diagnostic accuracy for predicting endoscopic response prior to treatment adjustment.<\/p>\n\n\n\n


Article: Circulating Extracellular Matrix Products as Indicators of Disease Burden and Predictors of Disease Course in Ulcerative Colitis<\/em><\/p>\n\n\n\n

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Find the article here<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Assessing disease burden and treatment response in ulcerative colitis (UC) remains challenging, often leading to treatment withdrawal and unresolved disease activity. These challenges highlight the need for better, non-invasive biomarkers to monitor disease activity and predict treatment outcomes. In our recently published paper “Circulating Extracellular Matrix Products as Indicators of Disease Burden and Predictors of […]<\/p>\n","protected":false},"author":4,"featured_media":19389,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[5191],"tags":[],"class_list":["post-19388","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2-minute-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/comments?post=19388"}],"version-history":[{"count":5,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19388\/revisions"}],"predecessor-version":[{"id":28177,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19388\/revisions\/28177"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media\/19389"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=19388"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/categories?post=19388"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/tags?post=19388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}