{"id":19385,"date":"2025-03-11T08:04:00","date_gmt":"2025-03-11T08:04:00","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?p=19385"},"modified":"2025-08-26T12:46:04","modified_gmt":"2025-08-26T12:46:04","slug":"hot-and-cold-fibrosis","status":"publish","type":"post","link":"https:\/\/www.nordicbioscience.com\/blog\/hot-and-cold-fibrosis\/","title":{"rendered":"Hot and Cold Fibrosis &#8211; A Novel Concept"},"content":{"rendered":"\n<p>We recently published an open assess review, where we and our collaborators have investigated the novel concept of \u201chot\u201d and \u201ccold\u201d fibrosis\u2014published in the <em>Journal of Hepatology<\/em>.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"530\" height=\"371\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/07\/hot-and-cold-fibrosis-fact-sheet.webp\" alt=\"\" class=\"wp-image-19386\" style=\"width:764px;height:auto\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/07\/hot-and-cold-fibrosis-fact-sheet.webp 530w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/07\/hot-and-cold-fibrosis-fact-sheet-300x210.webp 300w\" sizes=\"auto, (max-width: 530px) 100vw, 530px\" \/><figcaption class=\"wp-element-caption\"><em>The novel concept of &#8220;hot&#8221; and &#8220;cold&#8221; fibrosis refers to the immune status within fibrotic tissues and the nature of fibrogenic signaling<\/em><\/figcaption><\/figure><\/div>\n\n\n<p><br>Fibrosis is a pathological condition characterized by excessive accumulation of extracellular matrix (ECM) components, particularly collagens, leading to tissue scarring and organ dysfunction. The concept of \u201chot\u201d and \u201ccold\u201d fibrosis has recently emerged to help understanding the immune landscape within fibrotic tissues and how ECM and immune cell interactions could be new targets for future fibrosis treatment.<br><br>This review provides a new angle of describing fibrosis as \u201chot\u201d or \u201ccold\u201d, which refers to the immune status within fibrotic tissues and the nature of fibrogenic signaling. Whereas hot fibrosis is characterized by active immune cell infiltration and inflammation, cold fibrosis is associated with auto- and paracrine myofibroblast activation, immune cell exclusion and quiescence.<br><br>We demonstrate that pharmacodynamic biomarkers reflecting ECM remodeling are promising tools to monitor fibrotic and inflammatory processes in hepatic diseases, allowing to identify disease profiles associated either with hot or cold fibrosis. This also enables tailored strategies\u2014such as combining anti-fibrotic drugs with immune-stimulating therapies\u2014to optimize treatment efficacy.<\/p>\n\n\n\n<p><em>Article: Hot and cold fibrosis: The role of serum biomarkers to assess immune mechanisms and ECM-cell interactions in human fibrosis<\/em><\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168827825001485\">Find the article here<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>We recently published an open assess review, where we and our collaborators have investigated the novel concept of \u201chot\u201d and \u201ccold\u201d fibrosis\u2014published in the Journal of Hepatology. Fibrosis is a pathological condition characterized by excessive accumulation of extracellular matrix (ECM) components, particularly collagens, leading to tissue scarring and organ dysfunction. The concept of \u201chot\u201d and [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":19386,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[5191],"tags":[],"class_list":["post-19385","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2-minute-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19385","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/comments?post=19385"}],"version-history":[{"count":5,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19385\/revisions"}],"predecessor-version":[{"id":28179,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19385\/revisions\/28179"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media\/19386"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=19385"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/categories?post=19385"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/tags?post=19385"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}