{"id":19382,"date":"2025-04-08T07:31:00","date_gmt":"2025-04-08T07:31:00","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?p=19382"},"modified":"2025-08-26T12:51:41","modified_gmt":"2025-08-26T12:51:41","slug":"monitoring-therapeutic-responses-in-systemic-sclerosis-ssc","status":"publish","type":"post","link":"https:\/\/www.nordicbioscience.com\/blog\/monitoring-therapeutic-responses-in-systemic-sclerosis-ssc\/","title":{"rendered":"Monitoring Therapeutic Responses in Systemic Sclerosis"},"content":{"rendered":"\n

It can be a cumbersome clinical challenge to monitor subtle changes in collagen turnover in Systemic Sclerosis (SSc)<\/a>, a complex autoimmune condition marked by skin and organ fibrosis.<\/p>\n\n\n

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Systemic sclerosis (SSc) affects several tissues, leading to fibrotic tissue buildup of the skin and internal organs<\/em><\/figcaption><\/figure><\/div>\n\n\n


In our latest open-access paper in Arthritis Research & Therapy<\/em>, produced in collaboration with Dr. Satoshi Kubo, we reveal that although type VII collagen-an essential anchoring fibril in the skin\u2019s basement membrane\u2014is not directly linked to skin stiffness, its turnover is significantly elevated in SSc<\/a>, even when disease activity appears low.

We have shown that the dynamics of type VII collagen remodeling can be quantified using the serological biomarker PRO-C7<\/a>, measuring type VII collagen formation, and it’s counterpart measuring collagen degradation, C7M<\/a>. By tracking these biomarkers, clinicians can identify patients with hidden yet active collagen turnover, allowing for more personalized treatment strategies and better monitoring of therapeutic responses.

Article: Accelerated Type VII collagen turnover in systemic sclerosis patients, reflected by serological neo-epitope fragment biomarkers<\/em>
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Find the paper here<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

It can be a cumbersome clinical challenge to monitor subtle changes in collagen turnover in Systemic Sclerosis (SSc), a complex autoimmune condition marked by skin and organ fibrosis. In our latest open-access paper in Arthritis Research & Therapy, produced in collaboration with Dr. Satoshi Kubo, we reveal that although type VII collagen-an essential anchoring fibril […]<\/p>\n","protected":false},"author":4,"featured_media":19383,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[5191],"tags":[],"class_list":["post-19382","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2-minute-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/comments?post=19382"}],"version-history":[{"count":5,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19382\/revisions"}],"predecessor-version":[{"id":28183,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19382\/revisions\/28183"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media\/19383"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=19382"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/categories?post=19382"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/tags?post=19382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}