{"id":19375,"date":"2025-06-19T07:05:00","date_gmt":"2025-06-19T07:05:00","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?p=19375"},"modified":"2025-08-26T12:47:57","modified_gmt":"2025-08-26T12:47:57","slug":"investigating-type-iv-collagen-biomarkers-in-multiple-sclerosis","status":"publish","type":"post","link":"https:\/\/www.nordicbioscience.com\/blog\/investigating-type-iv-collagen-biomarkers-in-multiple-sclerosis\/","title":{"rendered":"Investigating Type IV Collagen Biomarkers in Multiple Sclerosis"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.nordicbioscience.com\/biomarker-solution\/neurology\/multiple-sclerosis\/\">Multiple sclerosis (MS)<\/a> is characterized as an inflammatory neurodegenerative disease in the central nervous system (CNS), presenting with significant inter- and intra individual heterogeneity. The pathological hallmarks of active MS lesions are blood brain barrier (BBB) disruption, inflammation, and demyelination with axonal damage. Blood-based biomarkers reflecting tissue changes in immunology and\/or neurobiology may reflect MS pathology and be easily accessible.  <\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/06\/ms-picture-1024x576.webp\" alt=\"\" class=\"wp-image-19381\" style=\"width:718px;height:auto\" srcset=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/06\/ms-picture-1024x576.webp 1024w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/06\/ms-picture-300x169.webp 300w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/06\/ms-picture-768x432.webp 768w, https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2025\/06\/ms-picture.webp 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Type IV collagen biomarkers in Multiple Sclerosis<\/em><\/figcaption><\/figure><\/div>\n\n\n<p>In our latest publication in &#8220;Multiple Sclerosis and Related Disorders&#8221;, we introduce <a href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/can\/\">nordicCAN<sup>TM<\/sup><\/a>, a technically robust assay, which targets a fragment of the \u03b12 chain of type IV collagen to detect canstatin (CAN) in human serum. This was evaluated as a biomarker for MS together with other type IV collagen biomarkers, and the results showed TUM to be an excellent diagnostic biomarker in MS, while CAN and PROC4 were both acceptable diagnostic biomarkers. <\/p>\n\n\n\n<p>To our knowledge, this is the first study to quantify fragments of type IV collagen in serum from patients with MS, and such biomarkers may be used to assess patients\u2019 eligibility for targeted treatments and fill a part of the gap for biomarkers in clinical management and trials.<\/p>\n\n\n\n<p><em>Article:<\/em> <em>Investigation of type IV collagen biomarkers in multiple sclerosis<\/em><\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.msard-journal.com\/article\/S2211-0348(25)00178-6\/fulltext\">Read the paper<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Multiple sclerosis (MS) is characterized as an inflammatory neurodegenerative disease in the central nervous system (CNS), presenting with significant inter- and intra individual heterogeneity. The pathological hallmarks of active MS lesions are blood brain barrier (BBB) disruption, inflammation, and demyelination with axonal damage. Blood-based biomarkers reflecting tissue changes in immunology and\/or neurobiology may reflect MS [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":19381,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[5191],"tags":[],"class_list":["post-19375","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2-minute-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/comments?post=19375"}],"version-history":[{"count":5,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19375\/revisions"}],"predecessor-version":[{"id":28182,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/posts\/19375\/revisions\/28182"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media\/19381"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=19375"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/categories?post=19375"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/tags?post=19375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}