{"id":1217,"date":"2025-01-27T09:45:06","date_gmt":"2025-01-27T09:45:06","guid":{"rendered":"https:\/\/www.nordicbioscience.com\/?post_type=biomarker&#038;p=1217"},"modified":"2025-06-10T09:18:37","modified_gmt":"2025-06-10T09:18:37","slug":"c1m","status":"publish","type":"biomarker","link":"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/c1m\/","title":{"rendered":"C1M"},"content":{"rendered":"\n<p>A neo-epitope fragment of type I collagen generated by MMP activity, quantifying pathological soft tissue destruction and extracellular matrix turnover.<\/p>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Key features and values<\/summary>\n<ul class=\"wp-block-list\">\n<li style=\"font-size:16px\">Measures degradation fragments of type I collagen resulting from matrix metalloproteinase activity.<\/li>\n\n\n\n<li>Reflects pathological soft tissue destruction and extracellular matrix remodeling.<\/li>\n\n\n\n<li>Enables non-invasive monitoring of connective tissue turnover in chronic and progressive diseases.<\/li>\n\n\n\n<li>Supports evaluation of disease progression in fibrotic, inflammatory, and degenerative disorders.<\/li>\n\n\n\n<li>Provides quantitative insights into the impact of therapeutic interventions targeting tissue remodeling.<\/li>\n\n\n\n<li>Applicable for research into mechanisms of fibrosis and extracellular matrix breakdown.<\/li>\n\n\n\n<li>Facilitates patient stratification and prognosis in studies of tissue-destructive conditions.<\/li>\n<\/ul>\n<\/details>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Description<\/summary>\n<p style=\"font-size:16px\">The C1M biomarker assay quantifies neo-epitope fragments of type I collagen that are generated through matrix metalloproteinase-driven cleavage, serving as a specific indicator of pathological soft tissue destruction and extracellular matrix remodeling. This non-invasive assay enables dynamic assessment of connective tissue turnover in a range of chronic and progressive diseases, including fibrotic, inflammatory, and degenerative conditions. By capturing changes in type I collagen breakdown, C1M supports research, monitoring of disease progression, and therapeutic development aimed at modulating tissue remodeling processes.<\/p>\n\n\n\n<p style=\"font-size:16px\"><em>Nordic Bioscience\u2019s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.<\/em><\/p>\n<\/details>\n\n\n\n<div style=\"height:var(--wp--preset--spacing--50)\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.nordicbioscience.com\/biomarker-portfolio\/?search=c1m\">Order C1M and other biomarkers<\/a><\/div>\n<\/div>\n\n\n<section class=\"two-column group white bg-white\">\n        <!-- \n        initialize dynamic classes\n        bg-greybg\n        bg-dark\n        xl:flex-row-reverse\n        xl:flex-row\n        -->\n   <div class=\"inner xl:p-10 lg:p-8 p-5 max-w-[1440px] mx-auto flex gap-4 xl:gap-10 flex-col xl:flex-row-reverse\">\n        <article class=\"flex flex-col justify-between flex-1 text-column\">\n            <div class=\"\">\n                <div>\n                                    <h2 class=\"mb-4 font-bold xl:mb-8 title text-m-title-lg xl:text-d-title-lg group-[.white]:text-navy group-[.grey]:text-navy group-[.dark]:text-fontlight\">Would you like to learn more? Contact us!<\/h2>\n                 \n\n                <\/div>\n                <div class=\"xl:mb-0 body-text group-[.white]:text-blue group-[.grey]:text-blue group-[.dark]:text-fontlightbody\">\n                    <div class=\"mb-10\">\n                        <div class=\"mb-4\">\n                                                    <\/div>\n                                            <\/div>\n                    \n<div class=\"wpcf7 no-js\" id=\"wpcf7-f170-o1\" lang=\"en-US\" dir=\"ltr\" data-wpcf7-id=\"170\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/wp-json\/wp\/v2\/biomarker\/1217#wpcf7-f170-o1\" method=\"post\" class=\"wpcf7-form init\" aria-label=\"Contact form\" novalidate=\"novalidate\" data-status=\"init\">\n<fieldset class=\"hidden-fields-container\"><input type=\"hidden\" name=\"_wpcf7\" value=\"170\" \/><input type=\"hidden\" name=\"_wpcf7_version\" value=\"6.1.3\" \/><input type=\"hidden\" name=\"_wpcf7_locale\" value=\"en_US\" \/><input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f170-o1\" \/><input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/><input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/><input type=\"hidden\" name=\"_wpcf7_recaptcha_response\" value=\"\" \/>\n<\/fieldset>\n<div class=\"row\">\n<label>Your scientific area\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"scientific-area\"><select class=\"wpcf7-form-control wpcf7-select wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" name=\"scientific-area\"><option value=\"\">Select area<\/option><option value=\"Cardiology\">Cardiology<\/option><option value=\"Dermatology\">Dermatology<\/option><option value=\"Gastroenterology\">Gastroenterology<\/option><option value=\"Hepatology\">Hepatology<\/option><option value=\"Nephrology\">Nephrology<\/option><option value=\"Neurology\">Neurology<\/option><option value=\"Obesity\">Obesity<\/option><option value=\"Pulmonology\">Pulmonology<\/option><option value=\"Rheumatology\">Rheumatology<\/option><option value=\"Multi-organ\/Other\">Multi-organ\/Other<\/option><\/select><\/span>\n    <\/label>\n<label>Your request\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"request\"><select class=\"wpcf7-form-control wpcf7-select wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" name=\"request\"><option value=\"\">Select request<\/option><option value=\"General inquiry\">General inquiry<\/option><option value=\"Biomarkers\">Biomarkers<\/option><option value=\"Laboratory\">Laboratory<\/option><option value=\"Something else\">Something else<\/option><\/select><\/span>\n    <\/label>\n<\/div>\n\n\n<div class=\"row\">\n<label> First name\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"first-name\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" autocomplete=\"name\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Jane\" value=\"\" type=\"text\" name=\"first-name\" \/><\/span> <\/label>\n<label> Last name\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"last-name\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" autocomplete=\"name\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Doe\" value=\"\" type=\"text\" name=\"last-name\" \/><\/span> <\/label>\n<\/div>\n<label> Email\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"your-email\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-email wpcf7-validates-as-required wpcf7-text wpcf7-validates-as-email\" autocomplete=\"email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Jane@doe.com\" value=\"\" type=\"email\" name=\"your-email\" \/><\/span> <\/label>\n\n<label> Company\/Organization (optional)\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"company-organization\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" autocomplete=\"company\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Your amazing company\" value=\"\" type=\"text\" name=\"company-organization\" \/><\/span> <\/label>\n\n<label> Phone (optional)\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"phonenumber\"><input size=\"40\" maxlength=\"400\" class=\"wpcf7-form-control wpcf7-tel wpcf7-text wpcf7-validates-as-tel\" autocomplete=\"tel\" aria-invalid=\"false\" placeholder=\"+45 12 23 34 45\" value=\"\" type=\"tel\" name=\"phonenumber\" \/><\/span> <\/label>\n\n<label> Your message (optional)\n    <span class=\"wpcf7-form-control-wrap\" data-name=\"your-message\"><textarea cols=\"40\" rows=\"10\" maxlength=\"2000\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\" placeholder=\"Non\u2010binding inquiry; BD team will follow up with details.\" name=\"your-message\"><\/textarea><\/span> <\/label>\n\n<span class=\"wpcf7-form-control-wrap\" data-name=\"acceptance\"><span class=\"wpcf7-form-control wpcf7-acceptance\"><span class=\"wpcf7-list-item\"><label><input type=\"checkbox\" name=\"acceptance\" value=\"1\" aria-invalid=\"false\" \/><span class=\"wpcf7-list-item-label\">Nordic Bioscience ApS and its non-profit partner, The Extracellular Matrix Pharmacology Congress, can contact me by email with news on research, events, products, and similar. I can always withdraw my consent at any time. This site is protected by reCAPTCHA and the Google\n    <a href=\"https:\/\/policies.google.com\/privacy\">Privacy Policy<\/a> and\n    <a href=\"https:\/\/policies.google.com\/terms\">Terms of Service<\/a> apply.<\/span><\/label><\/span><\/span><\/span>\n\n\n\n<input class=\"wpcf7-form-control wpcf7-submit has-spinner\" type=\"submit\" value=\"Submit request\" \/><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div>\n<\/form>\n<\/div>\n                <\/div>\n            <\/div>\n                    <\/article>\n        <figure class=\"flex-1 hidden h-auto rounded-md xl:block -order-1 xl:order-none xl:rounded-xl overflow-clip media-column shadow-main\">\n            <img decoding=\"async\" class=\"object-cover h-full\" src=\"https:\/\/www.nordicbioscience.com\/wp-content\/uploads\/2024\/12\/8f7ca89c8e79f07c1ca8c413139cd495-scaled.jpeg\" alt=\"a person wearing a blue lab coat, gloves, and safety glasses, working in a laboratory setting. They are using a pipette to transfer liquid into small bottles, surrounded by lab equipment and vials.\">\n        <\/figure>   \n   <\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>A neo-epitope fragment of type I collagen generated by MMP activity, quantifying pathological soft tissue destruction and extracellular matrix turnover.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"biomarker-panel":[80,68,5211,74,69,5262,54,5178,5188,5282,5280,67,5265],"commercial-assays":[],"therapeutic-area":[45,47,51,50,82,49,44],"class_list":["post-1217","biomarker","type-biomarker","status-publish","hentry","biomarker-panel-atherosclerotic-plaque-instability","biomarker-panel-bone-inflammation","biomarker-panel-copd","biomarker-panel-hidradenitis-suppurutiva","biomarker-panel-joint-tissue-remodeling","biomarker-panel-kidney-translational","biomarker-panel-lung-fibrosis","biomarker-panel-myocardial-infarction-mi","biomarker-panel-parkinsons-disease","biomarker-panel-proteolytic-activities","biomarker-panel-psoriatic-arthritis","biomarker-panel-rheumatrace","biomarker-panel-systemic-lupus-erythematosus","therapeutic-area-cancer","therapeutic-area-cardiovascular-diseases","therapeutic-area-dermatology","therapeutic-area-gastroenterology","therapeutic-area-neuroscience","therapeutic-area-respiratory-diseases","therapeutic-area-rheumatology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker\/1217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker"}],"about":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/types\/biomarker"}],"version-history":[{"count":13,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker\/1217\/revisions"}],"predecessor-version":[{"id":6834,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker\/1217\/revisions\/6834"}],"wp:attachment":[{"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/media?parent=1217"}],"wp:term":[{"taxonomy":"biomarker-panel","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/biomarker-panel?post=1217"},{"taxonomy":"commercial-assays","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/commercial-assays?post=1217"},{"taxonomy":"therapeutic-area","embeddable":true,"href":"https:\/\/www.nordicbioscience.com\/wp-json\/wp\/v2\/therapeutic-area?post=1217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}